SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1sp4 CATHEPSIN B
(Bos
taurus) 		4 / 7 HIS B 110
HIS B 111
HIS B 199
TRP B 221
 EP2  B  48 (-3.5A)
EP2  B  48 (-3.9A)
EP2  B  48 (-4.0A)
EP2  B  48 (-3.3A)
 0.36A 3ai8A-1sp4B:
30.5		 3ai8A-1sp4B:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1sp4 CATHEPSIN B
(Bos
taurus) 		5 / 6 TYR B 136
GLY B  99
VAL B  52
HIS B 145
SER B  90
 None
 1.48A 3tj7A-1sp4B:
0.0
3tj7B-1sp4B:
0.0		 3tj7A-1sp4B:
21.93
3tj7B-1sp4B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1sp4 CATHEPSIN B
(Bos
taurus) 		5 / 6 TYR B 136
GLY B  99
VAL B  52
HIS B 145
SER B  90
 None
 1.49A 3tj7C-1sp4B:
0.0
3tj7D-1sp4B:
0.0		 3tj7C-1sp4B:
21.93
3tj7D-1sp4B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1sp4 CATHEPSIN B
(Bos
taurus) 		4 / 8 ASN B 156
GLU B 243
ILE B 160
TRP B 215
 None
 1.13A 4d33A-1sp4B:
undetectable		 4d33A-1sp4B:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1sp4 CATHEPSIN B
(Bos
taurus) 		3 / 3 VAL B 208
GLU B 243
GLU B 157
 None
 0.84A 5jsdB-1sp4B:
undetectable
5jsdC-1sp4B:
undetectable		 5jsdB-1sp4B:
13.44
5jsdC-1sp4B:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1sp4 CATHEPSIN B
(Bos
taurus) 		5 / 10 PHE B 231
ILE B 242
PHE B 180
TRP B 225
GLY B 198
 None
None
None
None
EP2  B  48 (-3.6A)
 1.47A 5lbtA-1sp4B:
undetectable
5lbtB-1sp4B:
undetectable		 5lbtA-1sp4B:
21.67
5lbtB-1sp4B:
21.67