SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 10 VAL A 270
VAL A 181
VAL A 138
ASN A 275
LEU A 272
 None
 1.10A 1fe2A-1sp8A:
0.0		 1fe2A-1sp8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 HIS A 131
GLY A 298
GLY A 296
VAL A 299
TYR A 233
 None
 1.26A 1n2xA-1sp8A:
undetectable		 1n2xA-1sp8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 LEU A 370
VAL A 369
ILE A 392
VAL A 360
LEU A 310
 None
 1.16A 1s19A-1sp8A:
undetectable		 1s19A-1sp8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 5 LEU A 214
ALA A  72
LEU A  97
SER A  98
 None
 1.11A 1tt6B-1sp8A:
undetectable		 1tt6B-1sp8A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 PHE A 234
LEU A 272
VAL A  52
LEU A  97
LEU A 386
 None
 1.40A 2hc4A-1sp8A:
undetectable		 2hc4A-1sp8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 10 SER A  89
LEU A 100
LEU A 116
ASP A  79
THR A  82
 None
 1.41A 2j1gE-1sp8A:
0.0
2j1gF-1sp8A:
0.0		 2j1gE-1sp8A:
19.62
2j1gF-1sp8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 SER A 423
HIS A 301
ASP A 218
 None
FE2  A 500 (-3.4A)
None
 0.78A 2oxtA-1sp8A:
undetectable		 2oxtA-1sp8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 6 ARG A 391
PRO A 331
VAL A 360
MET A 328
 None
 1.49A 2qd4A-1sp8A:
undetectable		 2qd4A-1sp8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 7 THR A 289
GLN A 300
PHE A 385
PHE A 374
 None
 1.23A 2qx4A-1sp8A:
undetectable
2qx4B-1sp8A:
undetectable		 2qx4A-1sp8A:
20.43
2qx4B-1sp8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 THR A 102
PHE A 197
GLU A  53
ARG A 184
GLU A 174
 None
 1.20A 3apxA-1sp8A:
undetectable		 3apxA-1sp8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 10 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.29A 3fhjB-1sp8A:
undetectable		 3fhjB-1sp8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 10 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.33A 3fhjC-1sp8A:
undetectable		 3fhjC-1sp8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.34A 3fi0C-1sp8A:
undetectable		 3fi0C-1sp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.34A 3fi0H-1sp8A:
undetectable		 3fi0H-1sp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.39A 3fi0K-1sp8A:
undetectable		 3fi0K-1sp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.35A 3fi0N-1sp8A:
undetectable		 3fi0N-1sp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 GLY A 222
GLN A 300
HIS A 301
VAL A 138
VAL A 135
 None
None
FE2  A 500 (-3.4A)
None
None
 1.39A 3fi0O-1sp8A:
undetectable		 3fi0O-1sp8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 8 PHE A  99
SER A  94
LEU A 214
PHE A 217
 None
 0.99A 3i45A-1sp8A:
undetectable		 3i45A-1sp8A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 LEU A 420
GLY A 415
GLY A 338
VAL A 339
PRO A 331
 None
 1.10A 3nu5B-1sp8A:
undetectable		 3nu5B-1sp8A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 PHE A 327
SER A 320
GLN A 317
 None
 0.89A 3smtA-1sp8A:
undetectable		 3smtA-1sp8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 HIS A 294
GLY A 298
ALA A 134
ARG A 381
ALA A 128
 None
 1.07A 3sugA-1sp8A:
undetectable		 3sugA-1sp8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 12 PHE A  66
PHE A 101
LEU A  54
LEU A 304
PHE A 217
 None
 1.19A 4kykA-1sp8A:
0.5
4kykB-1sp8A:
5.8		 4kykA-1sp8A:
18.48
4kykB-1sp8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 8 ALA A 160
THR A  46
VAL A 270
PHE A 240
 None
 1.01A 4ltwA-1sp8A:
undetectable		 4ltwA-1sp8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 VAL A 299
ALA A 134
PHE A 290
 None
 0.56A 4olbA-1sp8A:
undetectable		 4olbA-1sp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 SER A 215
ASP A 307
GLN A 405
 None
 0.89A 4oltA-1sp8A:
undetectable
4oltB-1sp8A:
undetectable		 4oltA-1sp8A:
21.08
4oltB-1sp8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 6 LEU A  97
HIS A 219
HIS A 301
GLU A 387
 None
FE2  A 500 (-3.3A)
FE2  A 500 (-3.4A)
FE2  A 500 (-2.7A)
 1.01A 4pahA-1sp8A:
undetectable		 4pahA-1sp8A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 GLY A 162
PRO A 163
ALA A 145
 None
 0.55A 4qn9B-1sp8A:
undetectable		 4qn9B-1sp8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 GLN A 405
SER A 215
ASP A 307
 None
 0.86A 4qwpA-1sp8A:
undetectable
4qwpB-1sp8A:
undetectable		 4qwpA-1sp8A:
21.31
4qwpB-1sp8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 VAL A 299
ALA A 134
PHE A 290
 None
 0.61A 4w5nA-1sp8A:
undetectable		 4w5nA-1sp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 VAL A 299
ALA A 134
PHE A 290
 None
 0.55A 4z4iA-1sp8A:
undetectable		 4z4iA-1sp8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 5 ARG A  77
GLY A 203
THR A  82
GLU A 202
 None
 1.02A 5btiA-1sp8A:
undetectable
5btiB-1sp8A:
undetectable		 5btiA-1sp8A:
21.37
5btiB-1sp8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 5 ARG A  77
GLY A 203
THR A  82
GLU A 202
 None
 1.03A 5btiC-1sp8A:
undetectable
5btiD-1sp8A:
undetectable		 5btiC-1sp8A:
21.37
5btiD-1sp8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 5 ALA A 228
GLU A 276
ASN A 259
GLU A 245
 None
 1.36A 5dwkC-1sp8A:
undetectable		 5dwkC-1sp8A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		3 / 3 VAL A 299
ALA A 134
PHE A 290
 None
 0.56A 5js1A-1sp8A:
undetectable		 5js1A-1sp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		5 / 9 ALA A 157
SER A 152
ALA A 160
ALA A 173
GLY A 162
 None
 1.11A 6bklE-1sp8A:
undetectable
6bklF-1sp8A:
undetectable
6bklG-1sp8A:
undetectable
6bklH-1sp8A:
undetectable		 6bklE-1sp8A:
4.34
6bklF-1sp8A:
4.34
6bklG-1sp8A:
4.34
6bklH-1sp8A:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Zea
mays) 		4 / 6 LEU A  97
HIS A 219
HIS A 301
GLU A 387
 None
FE2  A 500 (-3.3A)
FE2  A 500 (-3.4A)
FE2  A 500 (-2.7A)
 1.04A 6pahA-1sp8A:
undetectable		 6pahA-1sp8A:
18.68