SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1spg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 11 ALA A 137
LEU A 138
LEU A 134
ILE A  64
ALA A  67
 None
HEM  A 144 ( 4.9A)
None
CMO  A 145 ( 4.0A)
HEM  A 144 (-3.4A)
 0.98A 1ha2A-1spgA:
undetectable		 1ha2A-1spgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 148 ( 4.5A)
None
HEM  B 148 (-3.9A)
HEM  B 148 (-3.2A)
 0.78A 1lh6A-1spgB:
13.0		 1lh6A-1spgB:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		3 / 3 ASP B   2
ASP B  79
LYS B 133
 None
 1.02A 1lqtB-1spgB:
undetectable		 1lqtB-1spgB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		3 / 3 ASP B   2
ASP B  79
LYS B 133
 None
 0.99A 1lquB-1spgB:
undetectable		 1lquB-1spgB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		3 / 3 ALA A  62
VAL A  57
TRP A  46
 None
None
HEM  A 144 (-4.2A)
 0.89A 1micA-1spgA:
undetectable
1micB-1spgA:
undetectable		 1micA-1spgA:
7.63
1micB-1spgA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 12 HIS B  63
ALA B  27
ILE B 109
VAL B  67
LEU B 142
 CMO  B 149 ( 3.9A)
None
None
HEM  B 148 (-3.9A)
HEM  B 148 (-4.9A)
 1.29A 1udtA-1spgB:
undetectable		 1udtA-1spgB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.98A 1wmqA-1spgA:
undetectable		 1wmqA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.98A 1wmqB-1spgA:
undetectable		 1wmqB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 1.00A 1wpuA-1spgA:
undetectable		 1wpuA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.99A 1wpuB-1spgA:
2.2		 1wpuB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.97A 1wrqA-1spgA:
1.2		 1wrqA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.97A 1wrqB-1spgA:
undetectable		 1wrqB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 9 LEU A  82
GLU A 140
SER A  86
SER A 139
LEU A 136
 None
 1.18A 2qmmA-1spgA:
undetectable		 2qmmA-1spgA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		6 / 11 LEU A  82
GLU A 140
SER A  86
LEU A 138
SER A 139
LEU A 136
 None
None
None
HEM  A 144 ( 4.9A)
None
None
 1.16A 2qmmA-1spgA:
undetectable
2qmmB-1spgA:
undetectable		 2qmmA-1spgA:
26.44
2qmmB-1spgA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 7 LEU A 134
ALA A  67
GLY A  69
PHE A 130
 None
HEM  A 144 (-3.4A)
None
None
 0.75A 2wq5A-1spgA:
undetectable		 2wq5A-1spgA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 8 MET A  65
ALA A  62
TRP A  14
GLY A  61
 None
 0.92A 2zm9A-1spgA:
undetectable		 2zm9A-1spgA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 12 LEU A  24
LEU A 134
LEU A 131
ALA A  67
ALA A  71
 None
None
None
HEM  A 144 (-3.4A)
None
 1.07A 3vw7A-1spgA:
undetectable		 3vw7A-1spgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 8 ILE B 110
LEU B 135
LYS B  12
PHE B 134
MET B  78
 None
 1.48A 4hb6A-1spgB:
undetectable		 4hb6A-1spgB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 8 ILE B 110
LEU B 135
LYS B  12
PHE B 134
MET B  78
 None
 1.38A 4hb8A-1spgB:
undetectable		 4hb8A-1spgB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 12 LEU A 131
LEU A 134
ALA A 137
SER A  86
LEU A  85
 None
None
None
None
HEM  A 144 ( 4.9A)
 1.20A 5mwyA-1spgA:
undetectable		 5mwyA-1spgA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 12 VAL B  67
PHE B 134
VAL B 114
LEU B 135
VAL B 138
 HEM  B 148 (-3.9A)
None
None
None
None
 1.21A 5tudD-1spgB:
undetectable		 5tudD-1spgB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 8 ILE B 110
TRP B 131
GLN B 132
VAL B 138
 None
 0.82A 5vlmF-1spgB:
0.0		 5vlmF-1spgB:
22.03