SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1spi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 12 SER A 273
VAL A 275
GLY A 276
GLY A 143
SER A 196
 None
 0.94A 1fduC-1spiA:
undetectable		 1fduC-1spiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 11 GLU A 315
ILE A 328
LEU A 342
TYR A 149
THR A 202
 None
 1.30A 1jomA-1spiA:
undetectable		 1jomA-1spiA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		4 / 7 TYR A 252
MET A 253
ASP A 254
ASP A 255
 None
 1.26A 1t03A-1spiA:
undetectable		 1t03A-1spiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 11 SER A  46
ALA A 105
PHE A  91
LEU A  95
ILE A 103
 None
 1.11A 1uduA-1spiA:
undetectable		 1uduA-1spiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 12 LEU A 221
PHE A 210
ILE A 313
ILE A 226
TYR A 208
 None
 1.20A 2efjA-1spiA:
undetectable		 2efjA-1spiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		4 / 5 LEU A  95
GLY A  99
ILE A 103
ILE A 104
 None
 0.83A 2q9rA-1spiA:
undetectable		 2q9rA-1spiA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		4 / 6 ILE A 328
PRO A 333
LEU A 303
ASP A 323
 None
 1.26A 3oi8A-1spiA:
undetectable		 3oi8A-1spiA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 12 TYR A 193
LEU A 130
PRO A 129
GLY A 143
LEU A  57
 None
 1.09A 3okxA-1spiA:
undetectable		 3okxA-1spiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 12 TYR A 193
LEU A 130
PRO A 129
GLY A 143
LEU A  57
 None
 1.05A 3okxB-1spiA:
0.0		 3okxB-1spiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 12 GLY A 276
ASN A 135
TYR A 290
CYH A 307
LEU A 301
 None
 1.32A 3ooiA-1spiA:
undetectable		 3ooiA-1spiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 10 LEU A  44
PHE A 312
ALA A 188
PHE A 146
GLY A 147
 None
 1.49A 3qpsA-1spiA:
undetectable		 3qpsA-1spiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 9 VAL A 125
VAL A 126
ILE A  47
GLY A 189
ALA A 187
 None
 1.00A 4fwdA-1spiA:
undetectable		 4fwdA-1spiA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 9 GLY A 289
GLY A 276
PHE A 278
LEU A 274
GLY A 272
 None
 1.06A 4kqiA-1spiA:
undetectable		 4kqiA-1spiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		4 / 7 VAL A  43
ILE A  47
PHE A 127
VAL A 125
 None
 0.73A 5bmvC-1spiA:
undetectable		 5bmvC-1spiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		4 / 6 GLU A 109
GLY A 121
ARG A 100
GLY A  99
 None
 0.93A 5cdpA-1spiA:
undetectable
5cdpB-1spiA:
undetectable		 5cdpA-1spiA:
20.20
5cdpB-1spiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		3 / 3 LEU A 186
PHE A 312
ILE A 203
 None
 0.74A 5dzk1-1spiA:
undetectable
5dzkF-1spiA:
undetectable
5dzkM-1spiA:
undetectable		 5dzk1-1spiA:
7.14
5dzkF-1spiA:
20.39
5dzkM-1spiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 10 TYR A 123
ILE A 148
ILE A 124
VAL A  43
ILE A 104
 None
 1.38A 5mzrA-1spiA:
undetectable		 5mzrA-1spiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 10 TYR A 123
ILE A 148
ILE A 124
VAL A  43
ILE A 104
 None
 1.39A 5mzrC-1spiA:
undetectable		 5mzrC-1spiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1spi FRUCTOSE
1,6-BISPHOSPHATASE
(Spinacia
oleracea) 		5 / 9 TYR A 123
ILE A 148
ILE A 124
VAL A  43
ILE A 104
 None
 1.38A 5mzrD-1spiA:
0.0		 5mzrD-1spiA:
11.42