SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1spj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 8 HIS A  57
ASP A 189
SER A 195
GLY A 216
 None
 0.62A 1aq7A-1spjA:
37.4		 1aq7A-1spjA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 None
 0.65A 1etrH-1spjA:
32.9		 1etrH-1spjA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 4 GLY A  19
ASP A 159
GLY A 184
THR A 213
 None
 0.85A 1hxbB-1spjA:
undetectable		 1hxbB-1spjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 THR A 241
ILE A  45
ILE A 238
SER A 214
ALA A  56
 None
 1.04A 1sg9B-1spjA:
undetectable		 1sg9B-1spjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 ALA A 228
GLY A 211
LEU A 199
ARG A 230
VAL A 132
 None
 1.20A 1vpoH-1spjA:
0.0
1vpoL-1spjA:
0.0		 1vpoH-1spjA:
22.31
1vpoL-1spjA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 10 ASP A 194
GLY A 196
GLY A  43
LEU A 199
ALA A 228
 None
 1.17A 1x7pA-1spjA:
undetectable
1x7pB-1spjA:
undetectable		 1x7pA-1spjA:
21.93
1x7pB-1spjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.43A 2oxtD-1spjA:
undetectable		 2oxtD-1spjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 6 TRP A 141
SER A 139
ALA A 138
ASP A 194
 None
 1.15A 3aruA-1spjA:
undetectable		 3aruA-1spjA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 None
 0.60A 3gy3A-1spjA:
37.4		 3gy3A-1spjA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 11 HIS A  57
GLN A 174
ASP A 189
TRP A 215
GLY A 216
 None
 0.93A 3gy3A-1spjA:
37.4		 3gy3A-1spjA:
42.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 7 TYR A  64
HIS A  35
LEU A  68
VAL A 212
 None
 1.10A 3jwqC-1spjA:
undetectable		 3jwqC-1spjA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 4 GLY A  19
ASP A 159
GLY A 184
THR A 213
 None
 0.84A 3k4vC-1spjA:
undetectable		 3k4vC-1spjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 8 ASP A 113
PRO A 111
GLN A  50
GLU A 110
 None
 1.10A 3oyaA-1spjA:
undetectable		 3oyaA-1spjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 VAL A 118
VAL A  83
GLY A  44
ALA A  31
LEU A  46
 None
 1.25A 3pghA-1spjA:
undetectable		 3pghA-1spjA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 7 ASP A 113
PRO A 111
GLN A  50
GLU A 110
 None
 1.11A 3s3oA-1spjA:
undetectable		 3s3oA-1spjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		3 / 3 SER A 226
ALA A 228
VAL A 229
 None
 0.54A 4o2bC-1spjA:
undetectable		 4o2bC-1spjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		3 / 3 SER A 226
ALA A 228
VAL A 229
 None
 0.38A 4x1iA-1spjA:
undetectable		 4x1iA-1spjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		3 / 3 SER A 226
ALA A 228
VAL A 229
 None
 0.59A 4x20C-1spjA:
undetectable		 4x20C-1spjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
 1.29A 5eiwC-1spjA:
undetectable		 5eiwC-1spjA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1spj KALLIKREIN 1
(Homo
sapiens) 		3 / 3 SER A 226
ALA A 228
VAL A 229
 None
 0.43A 5eypA-1spjA:
undetectable		 5eypA-1spjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1spj KALLIKREIN 1
(Homo
sapiens) 		3 / 3 THR A 115
ASP A 116
ALA A 117
 None
 0.00A 5g5gB-1spjA:
undetectable		 5g5gB-1spjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.96A 5vimA-1spjA:
undetectable		 5vimA-1spjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1spj KALLIKREIN 1
(Homo
sapiens) 		4 / 8 SER A  86
PHE A  89
HIS A  48
ILE A 242
 None
 0.87A 5vkqB-1spjA:
undetectable
5vkqC-1spjA:
undetectable		 5vkqB-1spjA:
8.83
5vkqC-1spjA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1spj KALLIKREIN 1
(Homo
sapiens) 		5 / 12 GLY A 197
TYR A  64
LEU A  33
GLY A  43
GLY A 196
 None
 0.90A 5wyqB-1spjA:
undetectable		 5wyqB-1spjA:
21.17