SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1spp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-I
MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		4 / 6 TYR B  70
GLU A 104
ILE B  34
GLY B  63
 None
 1.12A 1maaB-1sppB:
undetectable
1maaD-1sppB:
undetectable		 1maaB-1sppB:
11.05
1maaD-1sppB:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		5 / 12 SER B  83
VAL B  60
ILE B  90
ILE B 105
ILE B  46
 None
 0.77A 1qhsA-1sppB:
undetectable		 1qhsA-1sppB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		5 / 12 SER B  83
VAL B  60
ILE B  90
ILE B 105
ILE B  46
 None
 0.81A 1qhyA-1sppB:
undetectable		 1qhyA-1sppB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-I
MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa;
Sus
scrofa) 		4 / 7 ARG A 109
ALA B  45
ASP A  16
TYR B 106
 None
 1.01A 2e5dA-1sppA:
undetectable
2e5dB-1sppA:
undetectable		 2e5dA-1sppA:
12.88
2e5dB-1sppA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-I
MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa;
Sus
scrofa) 		4 / 7 ASP A  16
TYR B 106
ARG A 109
ALA B  45
 None
 1.01A 2e5dA-1sppA:
undetectable
2e5dB-1sppA:
undetectable		 2e5dA-1sppA:
12.88
2e5dB-1sppA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		5 / 12 SER B  21
ILE B  90
GLN B  26
ASN B   4
ILE B   3
 None
 1.25A 3ddyA-1sppB:
undetectable		 3ddyA-1sppB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		4 / 8 ILE B  79
LEU B  49
LYS B  91
ILE B  90
 None
 0.82A 4hb8A-1sppB:
undetectable		 4hb8A-1sppB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-I
(Sus
scrofa) 		4 / 7 LYS A  91
LEU A  61
GLU A  59
SER A  69
 None
 1.20A 4tvtA-1sppA:
undetectable		 4tvtA-1sppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-I
(Sus
scrofa) 		3 / 3 ASP A   5
GLY A  18
ASP A  15
 None
 0.64A 4xdtA-1sppA:
undetectable		 4xdtA-1sppA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1spp MAJOR SEMINAL PLASMA
GLYCOPROTEIN PSP-II
(Sus
scrofa) 		5 / 12 GLY B   5
TYR B  92
ILE B   3
ILE B 105
SER B  19
 None
 1.41A 4xudA-1sppB:
undetectable		 4xudA-1sppB:
20.36