SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1spx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 8 ALA A 165
LEU A 128
SER A 124
THR A  69
 None
 0.96A 1dvtA-1spxA:
undetectable
1dvtB-1spxA:
undetectable		 1dvtA-1spxA:
16.91
1dvtB-1spxA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ILE A  11
LEU A  87
VAL A 144
ALA A 243
ILE A 185
 None
 1.01A 1epbA-1spxA:
undetectable		 1epbA-1spxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ASP A 234
GLU A 237
ILE A 239
ILE A 190
THR A  22
 None
 1.26A 1kijA-1spxA:
undetectable		 1kijA-1spxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 8 ILE A 146
ILE A 239
GLU A 237
VAL A 238
ILE A 190
 None
 1.28A 1linA-1spxA:
undetectable		 1linA-1spxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 8 LEU A 136
ILE A 181
ILE A 185
THR A 129
 None
 0.95A 1sbrA-1spxA:
undetectable		 1sbrA-1spxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		3 / 3 SER A 151
GLY A 152
ARG A 174
 None
 0.60A 1t9wA-1spxA:
0.0		 1t9wA-1spxA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 8 ILE A 235
ILE A 239
ASN A  92
VAL A  91
ALA A   9
 None
 1.41A 2nniA-1spxA:
undetectable		 2nniA-1spxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 5 ALA A 165
ILE A 164
SER A 163
LYS A 109
 None
 1.10A 2othA-1spxA:
undetectable		 2othA-1spxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 7 THR A  22
ILE A  11
GLY A  19
ILE A 146
 None
 0.81A 2y7wC-1spxA:
undetectable		 2y7wC-1spxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 4 LEU A  77
ASP A  66
VAL A  63
THR A  34
 None
 1.16A 3cyxB-1spxA:
undetectable		 3cyxB-1spxA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 LEU A 136
THR A  12
ILE A  10
LEU A  77
THR A 176
 None
 1.04A 3hj3A-1spxA:
undetectable		 3hj3A-1spxA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		4 / 8 LEU A 122
SER A 147
SER A 189
SER A 191
 None
 0.94A 4ikkA-1spxA:
undetectable
4ikkB-1spxA:
undetectable		 4ikkA-1spxA:
18.84
4ikkB-1spxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ILE A  18
ILE A 146
ALA A 240
VAL A  91
VAL A 144
 None
 0.99A 4nkvA-1spxA:
undetectable		 4nkvA-1spxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ILE A  18
ILE A 146
ALA A 240
VAL A  91
VAL A 144
 None
 0.99A 4nkvC-1spxA:
undetectable		 4nkvC-1spxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ILE A  18
ILE A 146
ALA A 240
VAL A  91
VAL A 144
 None
 1.00A 4nkvD-1spxA:
undetectable		 4nkvD-1spxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 12 ILE A  18
ILE A 146
ALA A 240
VAL A  91
VAL A 144
 None
 0.90A 4nkxA-1spxA:
undetectable		 4nkxA-1spxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)
(Caenorhabditis
elegans) 		5 / 9 ASN A  16
ILE A 239
ILE A 235
VAL A 144
ILE A 190
 None
 1.45A 6hloA-1spxA:
6.4		 6hloA-1spxA:
18.58