SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 4 ILE A 287
MET A 214
VAL A 339
GLY A 274
 None
 1.42A 1e06B-1sq1A:
undetectable		 1e06B-1sq1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 ILE A 287
ASN A 271
SER A 273
ASN A 282
 None
 0.95A 1h7xA-1sq1A:
undetectable		 1h7xA-1sq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 ILE A 287
ASN A 271
SER A 273
ASN A 282
 None
 0.93A 1h7xB-1sq1A:
undetectable		 1h7xB-1sq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 ILE A 287
ASN A 271
SER A 273
ASN A 282
 None
 0.94A 1h7xC-1sq1A:
undetectable		 1h7xC-1sq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 ILE A 287
ASN A 271
SER A 273
ASN A 282
 None
 0.93A 1h7xD-1sq1A:
undetectable		 1h7xD-1sq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		5 / 8 ILE A 287
GLY A 246
GLY A 248
ILE A 249
ALA A 206
 None
 1.15A 1sguA-1sq1A:
undetectable		 1sguA-1sq1A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 8 PHE A 168
PHE A 208
GLU A 165
TYR A 291
 None
 1.38A 2aoxA-1sq1A:
undetectable		 2aoxA-1sq1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		5 / 12 GLY A  14
THR A   3
ARG A 126
ALA A 130
PHE A  10
 None
 1.00A 2gluB-1sq1A:
undetectable		 2gluB-1sq1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 GLY A 219
ILE A 280
ILE A 276
ASP A 224
 None
 0.95A 3a7eA-1sq1A:
undetectable		 3a7eA-1sq1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		5 / 8 LEU A 288
GLY A 275
GLY A 278
ILE A 280
ILE A 245
 None
 1.21A 3ekpA-1sq1A:
undetectable		 3ekpA-1sq1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		6 / 12 GLY A  67
GLY A  75
LEU A  65
PHE A  13
ASP A  26
ILE A  24
 SO4  A 402 (-3.5A)
None
None
None
None
None
 1.44A 3elwA-1sq1A:
undetectable		 3elwA-1sq1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 6 ALA A 334
LEU A 338
GLU A  42
ALA A 139
 None
 0.91A 3r9sA-1sq1A:
undetectable		 3r9sA-1sq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		3 / 3 PHE A 179
VAL A 330
GLU A  42
 None
 0.69A 4fvqA-1sq1A:
0.0		 4fvqA-1sq1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		4 / 7 ALA A 130
ILE A  25
LEU A 338
PHE A  10
 None
 1.13A 4uymB-1sq1A:
undetectable		 4uymB-1sq1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1sq1 CHORISMATE SYNTHASE
(Campylobacter
jejuni) 		5 / 12 GLY A  31
GLY A  67
GLY A  75
ILE A  25
ALA A  79
 None
SO4  A 402 (-3.5A)
None
None
None
 0.91A 5x7fA-1sq1A:
undetectable		 5x7fA-1sq1A:
20.49