SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.84A 1grmA-1sq4A:
undetectable		 1grmA-1sq4A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.84A 1grmB-1sq4A:
undetectable		 1grmB-1sq4A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.92A 1jo3A-1sq4A:
undetectable		 1jo3A-1sq4A:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.92A 1jo3B-1sq4A:
undetectable		 1jo3B-1sq4A:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.93A 1jo4A-1sq4A:
undetectable		 1jo4A-1sq4A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 223
VAL A 232
TRP A 231
 None
 0.93A 1jo4B-1sq4A:
undetectable		 1jo4B-1sq4A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 262
HIS A 214
LYS A 264
 SCN  A 302 ( 4.5A)
None
SCN  A 302 ( 3.9A)
 0.99A 1y7iA-1sq4A:
undetectable		 1y7iA-1sq4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 TYR A   7
GLY A 237
LEU A 219
HIS A 139
ILE A  33
 None
 1.30A 2a58A-1sq4A:
undetectable
2a58E-1sq4A:
undetectable		 2a58A-1sq4A:
21.86
2a58E-1sq4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  33
TYR A   7
GLY A 237
LEU A 219
HIS A 139
 None
 1.31A 2a58A-1sq4A:
undetectable
2a58B-1sq4A:
undetectable		 2a58A-1sq4A:
21.86
2a58B-1sq4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  33
TYR A   7
GLY A 237
LEU A 219
HIS A 139
 None
 1.30A 2a58B-1sq4A:
undetectable
2a58C-1sq4A:
undetectable		 2a58B-1sq4A:
21.86
2a58C-1sq4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  33
TYR A   7
GLY A 237
LEU A 219
HIS A 139
 None
 1.29A 2a58C-1sq4A:
undetectable
2a58D-1sq4A:
undetectable		 2a58C-1sq4A:
21.86
2a58D-1sq4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  33
TYR A   7
GLY A 237
LEU A 219
HIS A 139
 None
 1.31A 2a58D-1sq4A:
undetectable
2a58E-1sq4A:
undetectable		 2a58D-1sq4A:
21.86
2a58E-1sq4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 118
GLN A  70
PHE A  95
ILE A 195
LEU A 219
 None
 1.19A 3ia4C-1sq4A:
undetectable		 3ia4C-1sq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 262
TYR A 260
VAL A  37
ILE A  57
 SCN  A 302 ( 4.5A)
None
None
None
 1.32A 3ik3A-1sq4A:
undetectable		 3ik3A-1sq4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 262
TYR A 260
VAL A  37
ILE A  57
 SCN  A 302 ( 4.5A)
None
None
None
 1.28A 3ik3B-1sq4A:
undetectable		 3ik3B-1sq4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 213
ASP A 265
VAL A 211
ALA A 244
 None
 1.37A 5dl9A-1sq4A:
undetectable		 5dl9A-1sq4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 131
SER A 102
ASP A  82
 None
 0.75A 5kvaA-1sq4A:
undetectable		 5kvaA-1sq4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 131
SER A 102
ASP A  82
 None
 0.79A 5kvaB-1sq4A:
undetectable		 5kvaB-1sq4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 118
PHE A 119
TYR A 263
ILE A 141
LEU A 219
 None
 1.31A 5ljbA-1sq4A:
undetectable		 5ljbA-1sq4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1sq4 GLYOXYLATE-INDUCED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  55
ILE A  41
ASP A  40
 None
 0.76A 6i0y7-1sq4A:
undetectable		 6i0y7-1sq4A:
9.87