SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		9 / 9 ASP A1127
LEU A1130
LYS A1145
GLY A1146
HIS A1177
LEU A1201
TYR A1240
ILE A1281
ASN A1282
 PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
PAU  A6001 (-4.2A)
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.00A 1sq5A-1sq5A:
50.7		 1sq5A-1sq5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		10 / 10 ASP A1127
LEU A1130
LYS A1145
GLY A1146
HIS A1177
TYR A1180
LEU A1201
TYR A1240
ILE A1281
ASN A1282
 PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
PAU  A6001 (-4.2A)
None
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.11A 1sq5B-1sq5A:
49.0		 1sq5B-1sq5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		9 / 9 ASP A1127
LEU A1130
LYS A1145
GLY A1146
HIS A1177
LEU A1201
TYR A1240
ILE A1281
ASN A1282
 PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
PAU  A6001 (-4.2A)
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.08A 1sq5C-1sq5A:
47.9		 1sq5C-1sq5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		10 / 10 VAL A1097
ASP A1127
LEU A1130
LYS A1145
GLY A1146
HIS A1177
LEU A1201
TYR A1240
ILE A1281
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
PAU  A6001 (-4.2A)
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.10A 1sq5D-1sq5A:
49.2		 1sq5D-1sq5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 5 ILE A1066
ARG A1060
LEU A1062
ASN A1063
 None
 1.12A 1y0xX-1sq5A:
undetectable		 1y0xX-1sq5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 12 GLN A1109
ILE A1090
VAL A1223
ALA A1105
VAL A1203
 None
 1.31A 2g72B-1sq5A:
undetectable		 2g72B-1sq5A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 8 ASP A1127
TYR A1151
ASN A1202
GLY A1146
 PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
 1.02A 2ys6A-1sq5A:
undetectable		 2ys6A-1sq5A:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		6 / 6 VAL A1097
ASP A1127
LYS A1145
HIS A1177
TYR A1180
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
PAU  A6001 (-4.2A)
None
PAU  A6001 (-3.0A)
 0.61A 2zs9A-1sq5A:
37.4		 2zs9A-1sq5A:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 7 TYR A1240
PHE A1244
PHE A1259
ASN A1282
 PAU  A6001 (-4.3A)
None
None
PAU  A6001 (-3.0A)
 0.65A 2zseA-1sq5A:
37.2		 2zseA-1sq5A:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		8 / 8 VAL A1097
ASP A1127
LEU A1130
LYS A1145
GLY A1146
TYR A1151
HIS A1177
TYR A1180
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
None
PAU  A6001 (-3.3A)
None
PAU  A6001 (-4.2A)
None
 0.37A 3af0A-1sq5A:
37.5		 3af0A-1sq5A:
52.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		3 / 3 THR A1293
SER A1096
LYS A1101
 None
None
ADP  A5001 (-2.8A)
 1.21A 3aocC-1sq5A:
undetectable		 3aocC-1sq5A:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 11 ASP A1127
LEU A1130
LYS A1145
TYR A1175
ASN A1285
 PAU  A6001 (-2.9A)
None
None
None
None
 1.38A 3avoA-1sq5A:
37.3		 3avoA-1sq5A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		10 / 11 VAL A1097
ASP A1127
LEU A1130
LYS A1145
TYR A1151
TYR A1175
HIS A1177
TYR A1180
ILE A1281
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
None
None
None
PAU  A6001 (-4.2A)
None
PAU  A6001 (-3.7A)
PAU  A6001 (-3.0A)
 0.56A 3avoA-1sq5A:
37.3		 3avoA-1sq5A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		6 / 11 VAL A1097
ASP A1127
TYR A1175
HIS A1177
PHE A1259
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
PAU  A6001 (-4.2A)
None
PAU  A6001 (-3.0A)
 1.13A 3avoA-1sq5A:
37.3		 3avoA-1sq5A:
51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 7 VAL A1097
ASP A1127
HIS A1177
LEU A1201
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
PAU  A6001 (-4.2A)
None
PAU  A6001 (-3.0A)
 1.00A 3avpA-1sq5A:
37.1		 3avpA-1sq5A:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 7 VAL A1097
ASP A1127
LEU A1201
TYR A1240
ASN A1282
 ADP  A5001 ( 4.4A)
PAU  A6001 (-2.9A)
None
PAU  A6001 (-4.3A)
PAU  A6001 (-3.0A)
 0.92A 3avpA-1sq5A:
37.1		 3avpA-1sq5A:
52.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 7 TYR A1258
TYR A1262
PHE A1244
TYR A1240
 None
None
None
PAU  A6001 (-4.3A)
 1.25A 3ku9B-1sq5A:
undetectable		 3ku9B-1sq5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 12 LEU A1201
GLU A1295
GLY A1095
SER A1096
LEU A1204
 None
 1.42A 3ou6D-1sq5A:
undetectable		 3ou6D-1sq5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 8 ILE A1066
SER A1113
THR A1104
VAL A1121
 None
 0.79A 3ua5A-1sq5A:
undetectable		 3ua5A-1sq5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 6 MET A1029
ILE A1197
ILE A1195
VAL A1121
 None
 0.88A 4olmA-1sq5A:
0.0		 4olmA-1sq5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		3 / 3 VAL A1312
LEU A1301
VAL A1309
 None
 0.59A 4wq4A-1sq5A:
undetectable		 4wq4A-1sq5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		3 / 3 HIS A1118
GLU A1117
TRP A1115
 None
 1.19A 5odqD-1sq5A:
undetectable		 5odqD-1sq5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 5 GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.34A 6cduA-1sq5A:
undetectable
6cduB-1sq5A:
0.0		 6cduA-1sq5A:
21.85
6cduB-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 8 ILE A1290
GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.38A 6cduD-1sq5A:
undetectable
6cduE-1sq5A:
undetectable		 6cduD-1sq5A:
21.85
6cduE-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 7 THR A1125
ILE A1290
GLN A1205
VAL A1203
PRO A1148
 None
 1.33A 6cduF-1sq5A:
undetectable
6cduJ-1sq5A:
undetectable		 6cduF-1sq5A:
21.85
6cduJ-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		5 / 7 ILE A1290
GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.37A 6cduF-1sq5A:
undetectable
6cduG-1sq5A:
undetectable		 6cduF-1sq5A:
21.85
6cduG-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1sq5 PANTOTHENATE KINASE
(Escherichia
coli) 		4 / 8 ILE A1290
GLN A1205
VAL A1203
THR A1125
 None
 0.82A 6cduG-1sq5A:
undetectable
6cduH-1sq5A:
undetectable		 6cduG-1sq5A:
21.85
6cduH-1sq5A:
21.85