SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 205
SER A 198
SER A  92
LEU A  49
HIS A  61
 None
 1.29A 1db1A-1sqhA:
0.0		 1db1A-1sqhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		6 / 12 LEU A 170
GLY A 213
LEU A 179
LEU A 252
ILE A 223
LEU A 248
 None
 1.32A 1mx1D-1sqhA:
undetectable		 1mx1D-1sqhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		4 / 5 LEU A 268
VAL A 156
TYR A 288
THR A 267
 None
 1.45A 1nw3A-1sqhA:
undetectable		 1nw3A-1sqhA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 ALA A 224
VAL A 187
TRP A 191
 None
 0.95A 1tkqA-1sqhA:
undetectable		 1tkqA-1sqhA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 248
LEU A 252
ALA A 243
ILE A 176
LEU A 170
 None
 1.11A 1tw4A-1sqhA:
undetectable		 1tw4A-1sqhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 GLN A 112
HIS A  71
ARG A  72
 None
 0.98A 1zlqA-1sqhA:
undetectable		 1zlqA-1sqhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 10 SER A  94
PHE A  95
LEU A 106
TRP A 107
GLY A 130
 None
 1.17A 2b8jB-1sqhA:
undetectable		 2b8jB-1sqhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		4 / 7 SER A  97
ARG A 134
GLN A  99
GLU A 105
 None
 1.30A 2c8aA-1sqhA:
undetectable		 2c8aA-1sqhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 TRP A 271
VAL A 135
ARG A 142
 None
 0.67A 3b0wA-1sqhA:
undetectable		 3b0wA-1sqhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 THR A 125
SER A  92
PHE A  68
 None
 0.88A 3d4sA-1sqhA:
undetectable		 3d4sA-1sqhA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 GLY A 250
ILE A 226
GLY A 235
LEU A 251
PRO A 168
 None
 1.16A 3eeyD-1sqhA:
undetectable		 3eeyD-1sqhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 202
LEU A 205
VAL A 206
VAL A 187
LEU A 222
 None
 1.16A 3m7rA-1sqhA:
0.0		 3m7rA-1sqhA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 10 ALA A 181
LEU A 222
ARG A 177
HIS A 188
LEU A 199
 None
 1.37A 3uudB-1sqhA:
undetectable		 3uudB-1sqhA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		4 / 6 ASN A 229
GLU A 264
TYR A  40
LEU A  37
 None
 1.14A 4twdD-1sqhA:
undetectable
4twdE-1sqhA:
undetectable		 4twdD-1sqhA:
22.67
4twdE-1sqhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		4 / 6 ASN A 229
GLU A 264
TYR A  40
LEU A  37
 None
 1.27A 4twdI-1sqhA:
undetectable
4twdJ-1sqhA:
undetectable		 4twdI-1sqhA:
22.67
4twdJ-1sqhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 GLY A 143
ASN A 302
ALA A 122
GLN A 120
GLN A  91
 None
 1.23A 4ubeA-1sqhA:
undetectable		 4ubeA-1sqhA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 GLY A 121
GLN A  91
LYS A 298
 None
 0.94A 5imsB-1sqhA:
undetectable		 5imsB-1sqhA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 ALA A 270
LEU A 268
LEU A  37
PHE A 153
GLY A 154
 None
 1.13A 5jglA-1sqhA:
3.3		 5jglA-1sqhA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		3 / 3 GLY A 143
THR A 145
ASN A 302
 None
 0.59A 5odiG-1sqhA:
undetectable		 5odiG-1sqhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 9 ALA A 181
LEU A 222
ARG A 177
HIS A 188
LEU A 199
 None
 1.35A 5wgdA-1sqhA:
0.0		 5wgdA-1sqhA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1sqh HYPOTHETICAL PROTEIN
CG14615-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 283
PHE A 231
GLY A 233
TYR A 201
ILE A 226
 None
 1.12A 5y2tA-1sqhA:
undetectable		 5y2tA-1sqhA:
undetectable