SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		5 / 9 CYH A 153
LEU A 114
ILE A  99
THR A 150
ILE A 121
 None
 1.27A 1hzeA-1sqwA:
0.0
1hzeB-1sqwA:
0.0		 1hzeA-1sqwA:
20.42
1hzeB-1sqwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		5 / 9 THR A 150
ILE A 121
CYH A 153
LEU A 114
ILE A  99
 None
 1.27A 1hzeA-1sqwA:
0.0
1hzeB-1sqwA:
0.0		 1hzeA-1sqwA:
20.42
1hzeB-1sqwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 133
GLY A 130
ALA A 103
VAL A  97
GLY A 144
 None
 0.91A 2v0zO-1sqwA:
undetectable		 2v0zO-1sqwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		4 / 8 HIS A 175
LEU A 141
ILE A 139
LEU A 108
 None
 0.79A 2xfhA-1sqwA:
undetectable		 2xfhA-1sqwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		3 / 3 LYS A 115
LYS A 155
VAL A 156
 None
 1.04A 3brfA-1sqwA:
undetectable		 3brfA-1sqwA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		3 / 3 TYR A  95
LEU A 114
LYS A 115
 None
 0.71A 3sueD-1sqwA:
undetectable		 3sueD-1sqwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A  63
LEU A  66
ILE A  51
MET A  52
 None
 0.97A 4ww7A-1sqwA:
0.0		 4ww7A-1sqwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A  81
GLY A  71
TYR A  45
TYR A  19
LEU A  89
 None
 1.25A 5czyA-1sqwA:
0.0		 5czyA-1sqwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG
(Homo
sapiens) 		3 / 3 ASN A 124
SER A 126
SER A 149
 None
 0.49A 5gsnA-1sqwA:
undetectable		 5gsnA-1sqwA:
18.06