SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_A_DVAA6_0
(GRAMICIDIN D)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 5 ALA A 101
VAL A  90
TRP A  91
TRP A 116
 None
 1.48A 1al4A-1sr4A:
undetectable
1al4B-1sr4A:
undetectable		 1al4A-1sr4A:
7.69
1al4B-1sr4A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		5 / 12 ALA C 124
ILE C  40
LEU C  68
ILE B  47
THR C 120
 None
 1.25A 1d1gA-1sr4C:
undetectable		 1d1gA-1sr4C:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		5 / 12 ALA A 219
LEU C  45
SER B 268
ILE C 166
LEU C  42
 None
 1.16A 1dreA-1sr4A:
undetectable		 1dreA-1sr4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		4 / 7 ALA B 146
PHE B 157
VAL B 159
VAL B 196
 None
 0.89A 1epbA-1sr4B:
undetectable		 1epbA-1sr4B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		4 / 8 VAL B 147
PRO B  87
TYR C  29
VAL B 118
 None
 1.05A 1fduB-1sr4B:
undetectable		 1fduB-1sr4B:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		5 / 12 GLY C  83
GLY C  82
ASP C 129
TYR C 162
GLY C 150
 None
None
None
None
BR  C 524 (-3.5A)
 0.96A 1n2xB-1sr4C:
undetectable		 1n2xB-1sr4C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 GLU B  42
ASN B  46
TRP B  93
 None
 1.23A 1r15C-1sr4B:
undetectable		 1r15C-1sr4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 GLU B  42
ASN B  46
TRP B  93
 None
 1.26A 1r15D-1sr4B:
undetectable		 1r15D-1sr4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 GLU B  42
ASN B  46
TRP B  93
 None
 1.26A 1r15E-1sr4B:
undetectable		 1r15E-1sr4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 GLU B  42
ASN B  46
TRP B  93
 None
 1.25A 1r15F-1sr4B:
undetectable		 1r15F-1sr4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.98A 1v54A-1sr4A:
undetectable
1v54J-1sr4A:
undetectable		 1v54A-1sr4A:
18.06
1v54J-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.95A 1v54N-1sr4A:
undetectable
1v54W-1sr4A:
undetectable		 1v54N-1sr4A:
18.06
1v54W-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.94A 1v55A-1sr4A:
undetectable
1v55J-1sr4A:
undetectable		 1v55A-1sr4A:
18.06
1v55J-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 1.01A 2dyrA-1sr4A:
undetectable
2dyrJ-1sr4A:
0.0		 2dyrA-1sr4A:
18.06
2dyrJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.96A 2dyrN-1sr4A:
undetectable
2dyrW-1sr4A:
undetectable		 2dyrN-1sr4A:
18.06
2dyrW-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.98A 2dysA-1sr4A:
undetectable
2dysJ-1sr4A:
undetectable		 2dysA-1sr4A:
18.06
2dysJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.93A 2dysN-1sr4A:
undetectable
2dysW-1sr4A:
undetectable		 2dysN-1sr4A:
18.06
2dysW-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.97A 2eijA-1sr4A:
undetectable
2eijJ-1sr4A:
undetectable		 2eijA-1sr4A:
18.06
2eijJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 8 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.93A 2eijN-1sr4A:
undetectable
2eijW-1sr4A:
undetectable		 2eijN-1sr4A:
18.06
2eijW-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.97A 2eikA-1sr4A:
undetectable
2eikJ-1sr4A:
undetectable		 2eikA-1sr4A:
18.06
2eikJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.94A 2eilA-1sr4A:
undetectable
2eilJ-1sr4A:
undetectable		 2eilA-1sr4A:
18.06
2eilJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 SER B 171
HIS B 160
ASP B 112
 None
BR  B 523 (-4.5A)
None
 0.40A 2oxtA-1sr4B:
2.1		 2oxtA-1sr4B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 VAL B 118
ASN B  33
TRP B  32
 None
 0.66A 2y00B-1sr4B:
undetectable		 2y00B-1sr4B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 1.02A 2zxwA-1sr4A:
undetectable
2zxwJ-1sr4A:
0.0		 2zxwA-1sr4A:
18.06
2zxwJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 1.03A 3ablA-1sr4A:
undetectable
3ablJ-1sr4A:
undetectable		 3ablA-1sr4A:
18.06
3ablJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 1.05A 3abmA-1sr4A:
undetectable
3abmJ-1sr4A:
undetectable		 3abmA-1sr4A:
18.06
3abmJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.98A 3asnA-1sr4A:
undetectable
3asnJ-1sr4A:
0.0		 3asnA-1sr4A:
18.06
3asnJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.99A 3asoA-1sr4A:
undetectable
3asoJ-1sr4A:
undetectable		 3asoA-1sr4A:
18.06
3asoJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 TYR B 108
GLU B  66
ASP B 273
 None
 0.85A 3bxoA-1sr4B:
undetectable		 3bxoA-1sr4B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 TYR B 108
GLU B  66
ASP B 273
 None
 0.87A 3bxoB-1sr4B:
undetectable		 3bxoB-1sr4B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		5 / 12 ALA A 219
LEU C  45
SER B 268
ILE C 166
LEU C  42
 None
 1.31A 3ia4A-1sr4A:
undetectable		 3ia4A-1sr4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		5 / 12 ALA A 219
LEU C  45
SER B 268
ILE C 166
LEU C  42
 None
 1.31A 3ia4C-1sr4A:
undetectable		 3ia4C-1sr4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		5 / 11 ASP B 244
ALA B 240
PHE B  27
ILE B 224
ARG B 126
 None
 1.25A 3n23A-1sr4B:
undetectable		 3n23A-1sr4B:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		3 / 3 GLN A 208
THR A 202
LEU C 176
 None
 0.68A 3ondA-1sr4A:
undetectable		 3ondA-1sr4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		3 / 3 GLN A 208
THR A 202
LEU C 176
 None
 0.68A 3ondB-1sr4A:
undetectable		 3ondB-1sr4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi;
[Haemophilus]
ducreyi) 		4 / 8 TYR A 182
SER A 166
SER C 173
TYR A 211
 None
 1.01A 3rodA-1sr4A:
undetectable		 3rodA-1sr4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 SER B  25
PHE B  27
LYS B  28
 None
 0.80A 3u88A-1sr4B:
undetectable		 3u88A-1sr4B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 LEU B  52
MET B  63
ASP B 199
 None
None
BR  B 523 ( 4.8A)
 0.83A 3v5wA-1sr4B:
undetectable		 3v5wA-1sr4B:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		4 / 7 ARG B 125
ALA B 121
TRP B  93
ILE B 106
 None
 0.93A 3wsjB-1sr4B:
undetectable		 3wsjB-1sr4B:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi;
[Haemophilus]
ducreyi;
[Haemophilus]
ducreyi) 		4 / 6 GLY A 167
ARG B 267
ILE B 270
LEU C 176
 None
 1.22A 4ac9C-1sr4A:
undetectable		 4ac9C-1sr4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		4 / 8 ILE B 149
PRO B  71
VAL B 104
TRP B  93
 None
 1.32A 4f4dB-1sr4B:
undetectable		 4f4dB-1sr4B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		4 / 8 ILE C  40
ILE C 127
PHE C 125
GLY C 123
 None
 0.85A 4hb8A-1sr4C:
undetectable		 4hb8A-1sr4C:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		3 / 3 ALA B  30
GLN B  51
GLY C 123
 None
 0.61A 4odoC-1sr4B:
1.7		 4odoC-1sr4B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 6 LEU A 161
MET A  78
LEU A  80
VAL A 193
 None
 1.19A 4okbA-1sr4A:
undetectable		 4okbA-1sr4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		3 / 3 LEU A  87
LEU A 145
ASN A 131
 None
 0.61A 4otwA-1sr4A:
undetectable		 4otwA-1sr4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		5 / 11 LEU C 132
LEU C  79
ILE C 118
GLY C  83
LEU C  85
 None
 1.22A 4pxmB-1sr4C:
undetectable		 4pxmB-1sr4C:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		5 / 12 HIS B 231
ARG B 232
SER B 272
ILE B 270
HIS B 160
 None
None
None
None
BR  B 523 (-4.5A)
 1.34A 4qe6A-1sr4B:
undetectable		 4qe6A-1sr4B:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 THR B  31
HIS B 243
LEU B  24
 None
 0.75A 5axdA-1sr4B:
undetectable		 5axdA-1sr4B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 THR B  31
HIS B 243
LEU B  24
 None
 0.77A 5axdC-1sr4B:
undetectable		 5axdC-1sr4B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.98A 5b1bA-1sr4A:
undetectable
5b1bJ-1sr4A:
undetectable		 5b1bA-1sr4A:
18.06
5b1bJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		5 / 8 ILE B 224
VAL B 123
ILE B 149
ILE B 151
ASP B  60
 None
 1.37A 5hi2A-1sr4B:
undetectable		 5hi2A-1sr4B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
([Haemophilus]
ducreyi) 		4 / 7 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.92A 5iy5A-1sr4A:
undetectable
5iy5J-1sr4A:
undetectable		 5iy5A-1sr4A:
18.06
5iy5J-1sr4A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi) 		4 / 6 TYR C  61
PRO C 168
LEU C 167
PHE C 170
 None
 1.17A 5tl8A-1sr4C:
undetectable		 5tl8A-1sr4C:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 TRP B  93
MET B 103
ASN B 102
 None
BR  B 512 (-4.4A)
None
 1.38A 5uc1B-1sr4B:
0.0		 5uc1B-1sr4B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
([Haemophilus]
ducreyi) 		3 / 3 TRP B  93
MET B 103
ASN B 102
 None
BR  B 512 (-4.4A)
None
 1.37A 5uc1A-1sr4B:
undetectable		 5uc1A-1sr4B:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A
CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C
([Haemophilus]
ducreyi;
[Haemophilus]
ducreyi;
[Haemophilus]
ducreyi) 		5 / 12 TRP B  93
LEU B  95
VAL A 222
ALA A 219
PHE C 125
 None
 1.41A 6drxA-1sr4B:
undetectable		 6drxA-1sr4B:
21.52