SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  94
ARG A  40
ILE A  31
LEU A  38
 None
 0.73A 1jg4A-1sr8A:
undetectable		 1jg4A-1sr8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  45
ALA A  51
ASN A 142
ALA A  52
ILE A 158
 None
 1.08A 1likA-1sr8A:
undetectable		 1likA-1sr8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 6 GLU A  22
ARG A  40
LEU A   2
ASP A   4
 None
 1.03A 1mt1B-1sr8A:
0.0
1mt1C-1sr8A:
0.0		 1mt1B-1sr8A:
18.56
1mt1C-1sr8A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  56
ALA A  48
VAL A  63
GLU A  61
ASN A 142
 None
 1.09A 1sg9C-1sr8A:
undetectable		 1sg9C-1sr8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 243
ASP A 240
ILE A 260
GLY A 263
ILE A 239
 None
 1.12A 2avoA-1sr8A:
undetectable		 2avoA-1sr8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 9 GLY A 155
GLU A 112
ILE A  56
ALA A  52
VAL A  53
 None
 1.34A 2drdA-1sr8A:
undetectable		 2drdA-1sr8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 6 ARG A  40
GLU A   7
ILE A   6
PRO A   5
 None
 1.07A 2fcnA-1sr8A:
undetectable
2fcnB-1sr8A:
undetectable		 2fcnA-1sr8A:
13.56
2fcnB-1sr8A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 251
LEU A 258
LEU A 243
ASP A 240
 None
 1.02A 2rlfA-1sr8A:
undetectable
2rlfD-1sr8A:
undetectable		 2rlfA-1sr8A:
11.87
2rlfD-1sr8A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 7 VAL A 252
ARG A 278
ILE A 250
TYR A 222
 None
 1.15A 2yfbA-1sr8A:
undetectable		 2yfbA-1sr8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 252
ARG A 278
ILE A 250
TYR A 222
 None
 1.06A 2yfbB-1sr8A:
undetectable		 2yfbB-1sr8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		4 / 7 ALA A  51
ALA A  52
ALA A  54
GLN A 138
 None
 0.83A 3a2qA-1sr8A:
undetectable		 3a2qA-1sr8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		3 / 3 SER A 147
GLY A 154
GLY A 115
 None
 0.52A 3bogA-1sr8A:
undetectable
3bogC-1sr8A:
undetectable		 3bogA-1sr8A:
undetectable
3bogC-1sr8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 243
ASP A 240
ILE A 260
GLY A 263
ILE A 239
 None
 1.15A 3d1yB-1sr8A:
undetectable		 3d1yB-1sr8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 263
ALA A 262
ILE A 239
VAL A 281
ILE A 268
 None
 0.89A 3d1zA-1sr8A:
undetectable		 3d1zA-1sr8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 243
ASP A 240
ILE A 260
GLY A 263
ILE A 239
 None
 1.09A 3ekqB-1sr8A:
undetectable		 3ekqB-1sr8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 263
ALA A 262
ILE A 239
VAL A 237
ILE A 268
 None
 0.77A 3ekwB-1sr8A:
undetectable		 3ekwB-1sr8A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 263
ALA A 262
ILE A 239
VAL A 281
ILE A 268
 None
 0.89A 3nu5A-1sr8A:
undetectable		 3nu5A-1sr8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 243
ASP A 240
ILE A 260
GLY A 263
ILE A 239
 None
 0.97A 3tkgD-1sr8A:
undetectable		 3tkgD-1sr8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 12 TRP A 193
LEU A 197
ILE A  31
TYR A  11
TYR A 208
 None
 1.42A 4a79A-1sr8A:
undetectable		 4a79A-1sr8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 278
PHE A 235
LEU A 258
 None
 0.84A 5veuA-1sr8A:
undetectable		 5veuA-1sr8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)
(Archaeoglobus
fulgidus) 		5 / 9 THR A  44
GLY A  45
ALA A  48
GLY A 185
LEU A 184
 None
 1.30A 5vw4A-1sr8A:
undetectable		 5vw4A-1sr8A:
20.70