SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1srq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 TYR A 398
LEU A 112
LEU A 105
HIS A 402
 None
 1.37A 2x7hB-1srqA:
undetectable		 2x7hB-1srqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 312
SER A 311
LEU A 314
ILE A 288
LEU A 272
 None
 1.40A 4k39A-1srqA:
undetectable		 4k39A-1srqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 211
ILE A 309
TYR A 317
ASN A 290
 None
 1.20A 4o7gA-1srqA:
undetectable
4o7gB-1srqA:
0.3		 4o7gA-1srqA:
20.34
4o7gB-1srqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 365
VAL A 334
PHE A 220
THR A 213
SER A 269
 None
 1.32A 5xiqA-1srqA:
3.9		 5xiqA-1srqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 365
VAL A 334
PHE A 220
THR A 213
SER A 269
 None
 1.31A 5xiqB-1srqA:
3.7		 5xiqB-1srqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 195
PHE A 266
LEU A 227
PHE A 226
 None
 1.02A 5z84P-1srqA:
undetectable
5z84W-1srqA:
0.0		 5z84P-1srqA:
19.94
5z84W-1srqA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 195
PHE A 266
LEU A 227
PHE A 226
 None
 1.02A 5z85P-1srqA:
undetectable
5z85W-1srqA:
0.0		 5z85P-1srqA:
19.94
5z85W-1srqA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 195
PHE A 266
LEU A 227
PHE A 226
 None
 1.04A 5zcpP-1srqA:
0.0
5zcpW-1srqA:
0.0		 5zcpP-1srqA:
19.94
5zcpW-1srqA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ILE A 189
ASN A 371
CYH A 376
 None
 0.88A 6bp4A-1srqA:
undetectable		 6bp4A-1srqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 193
ILE A 264
LEU A 224
GLY A 196
PHE A 195
 None
 1.25A 6r2eA-1srqA:
0.0		 6r2eA-1srqA:
22.04