SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1srv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		3 / 3 ARG A 322
THR A 206
VAL A 214
 None
 0.95A 1hxbA-1srvA:
0.0		 1hxbA-1srvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 11 ALA A 251
VAL A 254
LEU A 289
THR A 296
ALA A 293
 None
 1.13A 1rv7A-1srvA:
undetectable
1rv7B-1srvA:
0.0		 1rv7A-1srvA:
17.69
1rv7B-1srvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ASN A 265
PHE A 204
ALA A 213
VAL A 227
LEU A 237
 None
 1.00A 1xdkA-1srvA:
undetectable		 1xdkA-1srvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
 None
 0.88A 1xdkA-1srvA:
undetectable		 1xdkA-1srvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 LEU A 314
THR A 313
LEU A 309
LEU A 221
GLY A 298
 None
 1.05A 2ouzA-1srvA:
undetectable		 2ouzA-1srvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		3 / 3 ARG A 322
THR A 206
VAL A 214
 None
 0.87A 2q64A-1srvA:
undetectable		 2q64A-1srvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 9 LEU A 221
LEU A 237
ALA A 275
LEU A 262
ALA A 258
 None
 1.23A 2vcvI-1srvA:
undetectable		 2vcvI-1srvA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
 None
 0.92A 3dzuA-1srvA:
undetectable		 3dzuA-1srvA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ILE A 249
ASN A 265
PHE A 204
VAL A 227
LEU A 237
 None
 1.09A 3dzyA-1srvA:
undetectable		 3dzyA-1srvA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ALA A 251
ILE A 301
VAL A 300
ILE A 292
ILE A 249
 None
 0.90A 3ekqA-1srvA:
undetectable		 3ekqA-1srvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 12 ALA A 251
ILE A 301
VAL A 300
ILE A 292
ILE A 249
 None
 0.92A 3ekwB-1srvA:
undetectable		 3ekwB-1srvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		4 / 8 ALA A 218
ASP A 217
GLY A 334
THR A 330
 None
 0.67A 3el9A-1srvA:
undetectable		 3el9A-1srvA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		4 / 8 ALA A 218
ASP A 217
GLY A 335
THR A 330
 None
 0.43A 3el9A-1srvA:
undetectable		 3el9A-1srvA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1srv PROTEIN (GROEL
(HSP60 CLASS))
(Thermus
thermophilus) 		5 / 9 PHE A 195
LEU A 248
VAL A 323
THR A 296
ILE A 332
 None
 1.15A 3tbgD-1srvA:
undetectable		 3tbgD-1srvA:
15.17