SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1stz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		4 / 5 PHE A 290
THR A 312
LEU A  84
ALA A 288
 None
 1.42A 2e1qD-1stzA:
undetectable		 2e1qD-1stzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		3 / 3 PRO A  79
PHE A  86
LYS A  82
 None
 1.23A 3bjwG-1stzA:
undetectable		 3bjwG-1stzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		5 / 12 LEU A 122
GLY A 124
VAL A 135
ARG A 139
PHE A 121
 None
 1.43A 3h52C-1stzA:
undetectable		 3h52C-1stzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		4 / 7 VAL A 304
GLY A 302
ILE A 301
VAL A 119
 None
 0.84A 3ufnB-1stzA:
undetectable		 3ufnB-1stzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		5 / 11 LEU A 160
TRP A 184
ILE A 187
LEU A 223
LEU A 219
 None
 1.41A 4yvpA-1stzA:
undetectable		 4yvpA-1stzA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		4 / 5 GLY A 280
ARG A 274
GLY A 276
GLU A 278
 None
 1.25A 4z2eB-1stzA:
2.3
4z2eC-1stzA:
undetectable		 4z2eB-1stzA:
24.31
4z2eC-1stzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		5 / 12 LEU A 284
ILE A 279
GLY A 276
LEU A 253
LEU A 239
 None
 1.01A 5nfjA-1stzA:
undetectable		 5nfjA-1stzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		5 / 12 SER A 329
GLU A 330
LEU A 325
ILE A 324
VAL A 119
 None
 1.16A 5vlmB-1stzA:
3.0		 5vlmB-1stzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		3 / 3 LEU A  15
GLN A  19
LYS A  82
 None
 0.77A 6exiB-1stzA:
undetectable		 6exiB-1stzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG
(Thermotoga
maritima) 		3 / 3 LEU A  15
GLN A  19
LYS A  82
 None
 0.77A 6exiA-1stzA:
undetectable		 6exiA-1stzA:
13.31