SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1su3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 11 ILE A 415
GLY A 421
PHE A 447
GLY A 423
PHE A 438
 None
 1.45A 1ho5A-1su3A:
undetectable		 1ho5A-1su3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 LEU A  73
LEU A  64
TYR A  37
LEU A  84
 None
 1.09A 1kt3A-1su3A:
undetectable		 1kt3A-1su3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.23A 1os2A-1su3A:
25.5		 1os2A-1su3A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.16A 1y93A-1su3A:
25.3		 1y93A-1su3A:
38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 PHE A 368
ARG A 405
ALA A 350
ARG A 341
 None
 1.17A 2e5dA-1su3A:
undetectable
2e5dB-1su3A:
undetectable		 2e5dA-1su3A:
22.71
2e5dB-1su3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 PHE A 368
ARG A 405
ALA A 350
ARG A 341
 None
 1.21A 2e5dA-1su3A:
undetectable
2e5dB-1su3A:
undetectable		 2e5dA-1su3A:
22.71
2e5dB-1su3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 LEU A 181
HIS A 218
HIS A 222
HIS A 228
 None
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.33A 2jihB-1su3A:
8.9		 2jihB-1su3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.33A 2ow9A-1su3A:
25.1		 2ow9A-1su3A:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.24A 2ozrF-1su3A:
24.8		 2ozrF-1su3A:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 12 VAL A 215
GLY A  93
TYR A 240
SER A 172
HIS A 183
 None
None
None
None
ZN  A 915 (-3.3A)
 1.35A 3bwmA-1su3A:
undetectable		 3bwmA-1su3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 ASP A 231
GLY A 233
ALA A 234
GLY A 271
 None
 0.58A 3em6A-1su3A:
undetectable		 3em6A-1su3A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 ARG A 165
ASP A 124
ASP A 200
 None
CA  A 902 (-2.1A)
None
 0.82A 3jb2A-1su3A:
undetectable		 3jb2A-1su3A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 ARG A 165
ASP A 124
ASP A 200
 None
CA  A 902 (-2.1A)
None
 0.83A 3jb3A-1su3A:
undetectable		 3jb3A-1su3A:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.28A 3likA-1su3A:
25.2		 3likA-1su3A:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.27A 3lkaA-1su3A:
25.2		 3lkaA-1su3A:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 ALA A  98
VAL A  97
GLN A  66
 None
 0.74A 3of4B-1su3A:
0.0		 3of4B-1su3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 PHE A 430
ALA A 428
PHE A 464
ALA A 460
 None
CL  A 909 ( 4.0A)
None
None
 0.97A 3t3sF-1su3A:
undetectable		 3t3sF-1su3A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.36A 4a7bA-1su3A:
25.3		 4a7bA-1su3A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 8 TYR A 116
ILE A 118
ILE A 161
ALA A 216
 None
 0.87A 4ou1A-1su3A:
undetectable		 4ou1A-1su3A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 TYR A 348
LYS A 362
PRO A 361
LEU A 357
 None
 1.47A 4w5qA-1su3A:
2.6		 4w5qA-1su3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 7 ASN A 346
LYS A 347
LEU A 328
PHE A 297
 None
 1.13A 4yv5B-1su3A:
undetectable		 4yv5B-1su3A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 GLN A 257
THR A 145
LEU A 235
LEU A 248
 None
 1.24A 5m5kB-1su3A:
undetectable		 5m5kB-1su3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 12 ALA A 249
ILE A 256
GLY A 255
LEU A 235
LEU A 226
 None
 1.01A 5nfjA-1su3A:
2.0		 5nfjA-1su3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 ARG A 337
PHE A 368
ARG A 341
 None
 1.23A 5y9yA-1su3A:
0.0		 5y9yA-1su3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
CYH A  92
HIS A 228
HIS A 222
 ZN  A 913 (-3.2A)
ZN  A 913 (-2.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 1.42A 5zrdA-1su3A:
0.0		 5zrdA-1su3A:
21.55