SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1su7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 VAL A 270
ILE A 306
GLY A 292
ILE A 293
ILE A 269
 None
 0.97A 1hpvA-1su7A:
undetectable		 1hpvA-1su7A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 LEU A 539
VAL A 440
GLY A 439
LEU A 535
 None
 0.92A 1jlbA-1su7A:
undetectable		 1jlbA-1su7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 LEU A 539
VAL A 440
VAL A 432
GLY A 439
LEU A 535
 None
 1.04A 1lwfA-1su7A:
undetectable		 1lwfA-1su7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 VAL A 270
ILE A 306
GLY A 292
ILE A 293
ILE A 269
 None
 0.92A 1n49B-1su7A:
undetectable		 1n49B-1su7A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 VAL A 270
ILE A 306
GLY A 292
ILE A 293
ILE A 269
 None
 0.91A 1n49C-1su7A:
undetectable		 1n49C-1su7A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 VAL A 270
ILE A 306
GLY A 292
ILE A 293
ILE A 269
 None
 0.98A 1ohrB-1su7A:
undetectable		 1ohrB-1su7A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU A 181
ALA A 178
LEU A 176
SER A 171
 None
 0.94A 1tz8C-1su7A:
undetectable
1tz8D-1su7A:
undetectable		 1tz8C-1su7A:
11.95
1tz8D-1su7A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 ILE A 293
ALA A 318
THR A 321
ALA A  12
 None
 0.90A 1w0gA-1su7A:
undetectable		 1w0gA-1su7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 LEU A 151
PHE A 154
MET A 225
LEU A 229
 None
 0.86A 2einA-1su7A:
2.2
2einJ-1su7A:
undetectable		 2einA-1su7A:
22.01
2einJ-1su7A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLU A 558
GLY A 581
LEU A 612
ASN A 456
PHE A 443
 None
 1.22A 2h21B-1su7A:
undetectable		 2h21B-1su7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 THR A  73
ASP A  83
SER A  85
 None
 0.85A 2nxeB-1su7A:
4.1		 2nxeB-1su7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 8 LEU A 220
ASP A 219
ALA A  90
ILE A 186
GLY A  95
 None
 1.17A 2o4nB-1su7A:
undetectable		 2o4nB-1su7A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 SER A 125
ASP A 139
ASP A 119
 None
 0.74A 2plwA-1su7A:
4.0		 2plwA-1su7A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU A 213
LEU A 210
GLN A 206
VAL A 592
LEU A  82
 None
 1.30A 2q7kA-1su7A:
undetectable		 2q7kA-1su7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 LEU A 550
PRO A 551
ARG A 542
 None
 0.65A 2qd5A-1su7A:
4.1		 2qd5A-1su7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 THR A 347
ALA A 382
ALA A 253
VAL A 291
GLY A 292
 None
 1.20A 2ve3B-1su7A:
undetectable		 2ve3B-1su7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 LEU A 151
PHE A 154
MET A 225
LEU A 229
 None
 0.92A 3asoN-1su7A:
undetectable
3asoW-1su7A:
undetectable		 3asoN-1su7A:
22.01
3asoW-1su7A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 VAL A 270
ILE A 306
GLY A 292
ILE A 293
ILE A 269
 None
 1.10A 3ekqB-1su7A:
undetectable		 3ekqB-1su7A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU A 213
SER A 216
LEU A 220
LEU A 181
 None
 0.71A 3f33A-1su7A:
undetectable		 3f33A-1su7A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU A 209
ARG A  80
PRO A 584
GLY A  45
 None
SF4  A 637 (-3.8A)
None
None
 0.93A 3hcrB-1su7A:
4.2		 3hcrB-1su7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 LEU A 539
VAL A 440
VAL A 432
GLY A 439
LEU A 535
 None
 1.04A 3lp1A-1su7A:
0.0		 3lp1A-1su7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY A 477
GLY A 479
PRO A 614
ASP A 454
PRO A 452
 None
 1.09A 3m6vA-1su7A:
undetectable		 3m6vA-1su7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 GLY A 200
ILE A  77
VAL A  76
 None
 0.44A 3nv6A-1su7A:
0.4		 3nv6A-1su7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 ILE A 126
LYS A 122
ALA A 143
LEU A 229
LEU A 104
 None
 1.09A 3o02A-1su7A:
0.0
3o02B-1su7A:
0.0		 3o02A-1su7A:
20.03
3o02B-1su7A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 LEU A 539
VAL A 440
VAL A 432
GLY A 439
LEU A 535
 None
 1.05A 3qipA-1su7A:
2.5		 3qipA-1su7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY A 581
GLY A 445
ALA A 559
ALA A 566
SER A 216
 None
NFS  A 639 (-3.6A)
None
None
None
 1.06A 3sudA-1su7A:
undetectable		 3sudA-1su7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 ILE A 190
PHE A 154
HIS A 261
VAL A 264
 None
None
NFS  A 639 (-3.3A)
None
 1.09A 4a97I-1su7A:
undetectable		 4a97I-1su7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 VAL A 469
ALA A 461
MET A 523
PHE A 407
VAL A 440
 None
 1.35A 4eilD-1su7A:
undetectable		 4eilD-1su7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 SER A 171
LEU A 181
ALA A 178
LEU A 176
 None
 0.81A 4ikjA-1su7A:
undetectable
4ikjB-1su7A:
undetectable		 4ikjA-1su7A:
11.95
4ikjB-1su7A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 LEU A 181
ALA A 178
LEU A 176
SER A 171
 None
 0.73A 4ikkA-1su7A:
undetectable
4ikkB-1su7A:
undetectable		 4ikkA-1su7A:
11.95
4ikkB-1su7A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 SER A 171
LEU A 181
ALA A 178
LEU A 176
 None
 0.73A 4iklA-1su7A:
undetectable
4iklB-1su7A:
undetectable		 4iklA-1su7A:
11.95
4iklB-1su7A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 7 MET A 302
PRO A 263
SER A 266
VAL A 527
 None
 1.31A 4kmmA-1su7A:
1.9		 4kmmA-1su7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 LEU A 176
ARG A 214
MET A 194
 None
 0.80A 4m11C-1su7A:
undetectable		 4m11C-1su7A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU A 621
ILE A 460
LEU A 464
ALA A 444
THR A 474
 None
 0.94A 4nkvB-1su7A:
0.0		 4nkvB-1su7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 ILE A 328
VAL A 256
ALA A 326
THR A 385
ALA A 280
 None
 1.28A 4oqrA-1su7A:
undetectable		 4oqrA-1su7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE A 132
ALA A 152
LEU A 130
ASP A 153
LEU A 162
 None
 1.06A 4pbhA-1su7A:
undetectable		 4pbhA-1su7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 ALA A 564
ILE A 460
VAL A 313
SER A 312
 None
None
None
NFS  A 639 (-3.3A)
 0.80A 4r20A-1su7A:
0.5		 4r20A-1su7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 GLY A 581
ALA A 444
ILE A 567
LEU A 576
ILE A 609
 None
 1.15A 4xumB-1su7A:
undetectable		 4xumB-1su7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 5 ALA A 113
TYR A 115
HIS A 363
PHE A 366
 None
 0.97A 4ze2A-1su7A:
undetectable		 4ze2A-1su7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 LEU A 504
LEU A 425
LEU A 470
ILE A 437
LEU A 539
 None
 1.03A 4zowA-1su7A:
undetectable		 4zowA-1su7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 7 HIS A 561
CYH A 333
GLY A  92
HIS A 261
 NFS  A 639 (-4.5A)
NFS  A 639 (-2.2A)
None
NFS  A 639 (-3.3A)
 1.14A 5a5zC-1su7A:
undetectable		 5a5zC-1su7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 ASP A 454
GLN A 453
GLY A 477
HIS A 522
HIS A 259
 None
 1.17A 5csyB-1su7A:
undetectable		 5csyB-1su7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		3 / 3 ASN A 255
ALA A 323
ARG A 389
 None
 0.72A 5cvtB-1su7A:
5.9		 5cvtB-1su7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 5 GLU A 189
ALA A 184
GLU A 156
GLU A 192
 None
 1.36A 5dwkC-1su7A:
2.9		 5dwkC-1su7A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 11 LEU A 539
VAL A 440
VAL A 432
GLY A 439
LEU A 535
 None
 1.07A 5hbmA-1su7A:
0.0		 5hbmA-1su7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 7 ILE A 293
GLY A 292
LEU A 100
CYH A 333
 None
None
None
NFS  A 639 (-2.2A)
 0.81A 5hieB-1su7A:
undetectable		 5hieB-1su7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 9 ILE A 350
VAL A 256
ASP A 330
ILE A 269
 None
 1.00A 5lg3I-1su7A:
undetectable		 5lg3I-1su7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY A 575
ILE A 574
TYR A 607
THR A 578
LEU A 217
 None
 1.03A 5nz0A-1su7A:
undetectable		 5nz0A-1su7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE A 269
ARG A 389
ILE A 396
ALA A 323
LEU A 324
 None
 1.19A 5oy02-1su7A:
0.0		 5oy02-1su7A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 7 GLY A 435
LEU A 425
GLY A 499
LEU A 500
ILE A 412
 None
 1.29A 5vkqA-1su7A:
2.4
5vkqB-1su7A:
2.4		 5vkqA-1su7A:
17.06
5vkqB-1su7A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 ILE A 269
ARG A 389
ILE A 396
ALA A 323
LEU A 324
 None
 1.26A 5zjiB-1su7A:
4.5		 5zjiB-1su7A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 5 THR A 401
LEU A 495
VAL A 471
LEU A 504
 None
 1.01A 6bqgA-1su7A:
2.0		 6bqgA-1su7A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 9 VAL A 440
LEU A 470
GLY A 499
LEU A 500
VAL A 432
 None
 1.25A 6czmD-1su7A:
undetectable
6czmE-1su7A:
1.7		 6czmD-1su7A:
22.15
6czmE-1su7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 10 ALA A 415
LEU A 428
LEU A 521
MET A 523
LEU A 470
 None
 0.95A 6f5uA-1su7A:
0.2
6f5uB-1su7A:
undetectable		 6f5uA-1su7A:
8.05
6f5uB-1su7A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 PHE A 154
LEU A 151
ALA A 150
ASN A 262
 None
 1.02A 6f88A-1su7A:
undetectable		 6f88A-1su7A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU A  46
THR A  44
CYH A  47
GLY A  40
 None
None
FES  A 638 (-2.2A)
None
 1.18A 6gtqB-1su7A:
undetectable
6gtqD-1su7A:
undetectable		 6gtqB-1su7A:
13.25
6gtqD-1su7A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 8 ILE A 193
ALA A  79
VAL A  78
ARG A  80
 None
None
None
SF4  A 637 (-3.8A)
 0.83A 6hu9a-1su7A:
1.8
6hu9e-1su7A:
undetectable		 6hu9a-1su7A:
22.37
6hu9e-1su7A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		5 / 8 VAL A 164
GLY A  92
SER A  94
ALA A  97
LYS A  98
 None
 1.48A 6hu9H-1su7A:
undetectable
6hu9e-1su7A:
0.0		 6hu9H-1su7A:
8.79
6hu9e-1su7A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1su7 CARBON MONOXIDE
DEHYDROGENASE 2
(Carboxydothermus
hydrogenoformans) 		4 / 6 ILE A 412
ALA A 532
ARG A 531
ASP A 228
 None
 1.04A 6hu9m-1su7A:
0.9
6hu9q-1su7A:
0.0		 6hu9m-1su7A:
22.37
6hu9q-1su7A:
10.99