SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_B_SALB900_1 (PROSTAGLANDIN G/H SYNTHASE 1)	1sum	PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (Thermotoga maritima)	4 / 5	VAL B 155 LEU B 158 ILE B 119 ALA B 123	None	0.79A	3n8yB-1sumB: undetectable	3n8yB-1sumB: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S56_B_ROCB203_1 (PROTEASE)	1sum	PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (Thermotoga maritima)	4 / 7	LEU B 166 LEU B 183 PRO B 120 ILE B 119	None	0.89A	3s56B-1sumB: undetectable	3s56B-1sumB: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JNC_D_ACTD305_0 (CARBONIC ANHYDRASE 4)	1sum	PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (Thermotoga maritima)	4 / 5	PRO B 120 ALA B 123 ILE B 31 LEU B 34	None	0.79A	5jncD-1sumB: undetectable	5jncD-1sumB: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JS5_A_ASCA202_0 (CYTOCHROME C')	1sum	PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (Thermotoga maritima)	3 / 3	CYH B 97 LYS B 96 HIS B 98	None	1.11A	5js5A-1sumB: 4.2	5js5A-1sumB: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QH8_A_ACTA302_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1sum	PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2 (Thermotoga maritima)	3 / 3	CYH B 97 MET B 26 ASN B 29	None	1.38A	5qh8A-1sumB: undetectable	5qh8A-1sumB: 19.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3N8Y_B_SALB900_1","PROSTAGLANDIN G\/H SYNTHASE 1","1sum","PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2","Thermotoga maritima",4,"VAL B 155;LEU B 158;ILE B 119;ALA B 123","None","0.79A","3n8yB-1sumB:undetectable","3n8yB-1sumB:17.76"],["3S56_B_ROCB203_1","PROTEASE","1sum","PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2","Thermotoga maritima",4,"LEU B 166;LEU B 183;PRO B 120;ILE B 119","None","0.89A","3s56B-1sumB:undetectable","3s56B-1sumB:16.81"],["5JNC_D_ACTD305_0","CARBONIC ANHYDRASE 4","1sum","PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2","Thermotoga maritima",4,"PRO B 120;ALA B 123;ILE B  31;LEU B  34","None","0.79A","5jncD-1sumB:undetectable","5jncD-1sumB:22.34"],["5JS5_A_ASCA202_0","CYTOCHROME C'","1sum","PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2","Thermotoga maritima",3,"CYH B  97;LYS B  96;HIS B  98","None","1.11A","5js5A-1sumB:4.2","5js5A-1sumB:18.60"],["5QH8_A_ACTA302_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1sum","PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU HOMOLOG 2","Thermotoga maritima",3,"CYH B  97;MET B  26;ASN B  29","None","1.38A","5qh8A-1sumB:undetectable","5qh8A-1sumB:19.92"]]