SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sur'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		5 / 12 LYS A 144
VAL A  48
VAL A 175
TYR A  47
PRO A  72
 None
 1.35A 2zd1A-1surA:
0.0		 2zd1A-1surA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A   5
LEU A   8
ASN A   9
LEU A  11
LEU A 169
 None
 1.17A 3d90A-1surA:
undetectable		 3d90A-1surA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		4 / 5 LEU A 100
LEU A  98
LEU A  49
SER A  50
 None
 1.02A 3vhuA-1surA:
undetectable		 3vhuA-1surA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		3 / 3 TYR A 130
THR A  78
GLU A 113
 None
 0.75A 4df3A-1surA:
undetectable		 4df3A-1surA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		3 / 3 TYR A 130
THR A  78
GLU A 113
 None
 0.71A 4df3B-1surA:
undetectable		 4df3B-1surA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		3 / 3 LYS A 177
LEU A 179
ALA A 170
 None
 0.56A 4iizA-1surA:
undetectable		 4iizA-1surA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		5 / 10 GLU A  28
ALA A  37
GLY A  34
ALA A  32
ASP A 183
 None
 1.17A 5lf3H-1surA:
undetectable
5lf3I-1surA:
undetectable		 5lf3H-1surA:
22.35
5lf3I-1surA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1sur PAPS REDUCTASE
(Escherichia
coli) 		5 / 10 GLU A  28
ALA A  37
GLY A  34
ALA A  32
ASP A 183
 None
 1.19A 5lf3V-1surA:
undetectable
5lf3W-1surA:
undetectable		 5lf3V-1surA:
22.35
5lf3W-1surA:
21.03