SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1suu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 LEU A 705
GLY A 670
ALA A 756
LEU A 713
ASP A 699
 None
 1.00A 1bx4A-1suuA:
undetectable		 1bx4A-1suuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		4 / 5 LEU A 551
VAL A 510
LEU A 518
GLN A 586
 None
 0.87A 1fbmE-1suuA:
undetectable		 1fbmE-1suuA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 1qzfA-1suuA:
undetectable		 1qzfA-1suuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 1qzfB-1suuA:
undetectable		 1qzfB-1suuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 1qzfC-1suuA:
undetectable		 1qzfC-1suuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 1qzfD-1suuA:
undetectable		 1qzfD-1suuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 1qzfE-1suuA:
undetectable		 1qzfE-1suuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 9 THR A 777
VAL A 716
GLY A 722
VAL A 759
ILE A 757
 None
 1.32A 2a1oB-1suuA:
undetectable		 2a1oB-1suuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 VAL A 753
ALA A 756
SER A 671
THR A 652
LEU A 695
 None
 1.13A 2oipA-1suuA:
undetectable		 2oipA-1suuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 12 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.37A 2q63A-1suuA:
undetectable		 2q63A-1suuA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 12 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.37A 2q64B-1suuA:
undetectable		 2q64B-1suuA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 10 ILE A 656
PHE A 632
THR A 602
ILE A 562
LEU A 617
 None
 1.23A 2w3aB-1suuA:
undetectable		 2w3aB-1suuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 12 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.33A 2z54B-1suuA:
undetectable		 2z54B-1suuA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		3 / 3 MET A 727
VAL A 759
GLU A 784
 None
 0.86A 3c6gA-1suuA:
0.0		 3c6gA-1suuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 12 THR A 652
THR A 619
THR A 618
LEU A 695
LEU A 645
 None
 1.38A 3gwxB-1suuA:
undetectable		 3gwxB-1suuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 11 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.49A 3nu3B-1suuA:
undetectable		 3nu3B-1suuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 9 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.44A 3nujB-1suuA:
undetectable		 3nujB-1suuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 9 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.44A 3nuoB-1suuA:
undetectable		 3nuoB-1suuA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 12 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.44A 4jecA-1suuA:
undetectable		 4jecA-1suuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 9 GLY A 739
SER A 671
ASP A 699
SER A 667
THR A 738
 None
 1.13A 4lb0A-1suuA:
0.0		 4lb0A-1suuA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		4 / 8 VAL A 768
LEU A 766
TYR A 526
GLN A 523
 None
 0.83A 4ma7A-1suuA:
undetectable		 4ma7A-1suuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		3 / 3 LEU A 705
LEU A 615
ASN A 605
 None
 0.75A 4otwA-1suuA:
undetectable		 4otwA-1suuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 9 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.48A 4rvjB-1suuA:
undetectable		 4rvjB-1suuA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 9 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.48A 4rvjD-1suuA:
undetectable		 4rvjD-1suuA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 9 ILE A 656
VAL A 642
LEU A 568
ILE A 562
TYR A 558
 None
 1.29A 5iepA-1suuA:
undetectable		 5iepA-1suuA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		6 / 12 GLY A 780
ALA A 779
VAL A 805
GLY A 722
ILE A 792
ILE A 765
 None
 1.49A 6dilB-1suuA:
undetectable		 6dilB-1suuA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		5 / 9 THR A 652
GLY A 622
ILE A 624
PHE A 701
ILE A 643
 None
 1.33A 6ebpA-1suuA:
undetectable		 6ebpA-1suuA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1suu DNA GYRASE SUBUNIT A
(Borreliella
burgdorferi) 		3 / 3 LYS A 696
SER A 667
SER A 671
 None
 1.09A 6gbfA-1suuA:
undetectable		 6gbfA-1suuA:
23.54