SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1suv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 474
SER A 499
LEU A 501
GLY A 549
 None
 1.04A 1a4lB-1suvA:
undetectable		 1a4lB-1suvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 466
VAL A 461
TRP A 453
 None
 1.25A 1c4dA-1suvA:
undetectable
1c4dB-1suvA:
undetectable		 1c4dA-1suvA:
3.70
1c4dB-1suvA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 728
LEU A 639
LEU A 637
GLY A 636
PHE A 726
 None
 1.48A 1d4fD-1suvA:
2.9		 1d4fD-1suvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TYR A 643
LEU A 639
VAL E 360
ASP E 356
 None
 1.49A 1dz6A-1suvA:
0.0		 1dz6A-1suvA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 656
ARG A 651
PHE A 649
GLY A 647
 None
 0.79A 1fapB-1suvA:
0.0		 1fapB-1suvA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 415
ASP A 162
SER A 419
ALA A 157
 None
 0.97A 1gxsA-1suvA:
4.4
1gxsB-1suvA:
0.7		 1gxsA-1suvA:
17.91
1gxsB-1suvA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 281
LYS A 267
ALA A 271
VAL A 334
 None
 0.93A 1hk1A-1suvA:
2.7		 1hk1A-1suvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 8 ARG A 409
SER A 452
VAL A 169
ASN A 164
ASP A 162
 None
 1.48A 1hwiB-1suvA:
undetectable		 1hwiB-1suvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_2
(HMG-COA REDUCTASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 9 ARG A 409
SER A 452
VAL A 169
ASN A 164
ASP A 162
 None
 1.45A 1hwkB-1suvA:
0.0		 1hwkB-1suvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 8 ARG A 409
SER A 452
VAL A 169
ASN A 164
ASP A 162
 None
 1.49A 1hwkD-1suvA:
undetectable		 1hwkD-1suvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A 158
ALA A 221
TYR A 222
HIS A 300
PHE A 298
 None
 1.26A 1jglH-1suvA:
undetectable
1jglL-1suvA:
undetectable		 1jglH-1suvA:
14.87
1jglL-1suvA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 12 HIS E 582
TYR E 412
GLN E 537
TYR E 514
GLU E 410
 FE  E 703 ( 3.3A)
None
None
CO3  E 701 ( 3.8A)
None
 1.30A 1ki3A-1suvE:
0.0		 1ki3A-1suvE:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 12 LEU E 426
LEU E 576
PHE E 479
LEU E 558
HIS E 450
 None
 1.33A 1kt5A-1suvE:
undetectable		 1kt5A-1suvE:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 PHE E 518
TRP E 547
GLU E 545
 None
 1.10A 1mogA-1suvE:
undetectable		 1mogA-1suvE:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		6 / 12 THR A 239
ALA A 235
LEU A 232
ILE A 332
ILE A 277
GLY A 252
 None
 1.31A 1qknA-1suvA:
undetectable		 1qknA-1suvA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 11 MET E 463
ARG E 469
GLY E 445
GLU E 444
HIS E 450
 None
 1.37A 1vhwC-1suvE:
undetectable
1vhwE-1suvE:
undetectable		 1vhwC-1suvE:
20.61
1vhwE-1suvE:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 11 HIS E 450
MET E 463
ARG E 469
GLY E 445
GLU E 444
 None
 1.37A 1vhwA-1suvE:
undetectable
1vhwD-1suvE:
undetectable		 1vhwA-1suvE:
20.61
1vhwD-1suvE:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 9 PHE E 628
LEU E 599
PHE E 619
MET E 618
LEU E 408
 None
 1.33A 1wrkA-1suvE:
0.0
1wrkB-1suvE:
undetectable		 1wrkA-1suvE:
18.15
1wrkB-1suvE:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 7 LEU E 576
PRO E 462
GLY E 394
ASP E 392
 None
None
None
FE  E 703 ( 3.0A)
 1.05A 2ddwB-1suvE:
undetectable		 2ddwB-1suvE:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 8 TYR E 425
GLY E 513
GLY E 458
THR E 456
ALA E 457
 FE  E 703 ( 4.1A)
None
CO3  E 701 (-4.0A)
CO3  E 701 (-4.2A)
CO3  E 701 (-3.5A)
 1.27A 2ej3C-1suvE:
undetectable		 2ej3C-1suvE:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 LYS E 524
GLY E 499
PRO E 500
 None
 0.94A 2hreB-1suvE:
undetectable		 2hreB-1suvE:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 1suv SEROTRANSFERRIN,
C-LOBE
TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLU A 759
PRO E 505
ARG E 508
GLY E 499
 None
 1.28A 2hs1B-1suvA:
undetectable		 2hs1B-1suvA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 THR E 534
ASP E 392
SER E 390
 None
FE  E 703 ( 3.0A)
None
 0.85A 2nxeA-1suvE:
undetectable		 2nxeA-1suvE:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 THR E 534
ASP E 392
SER E 390
 None
FE  E 703 ( 3.0A)
None
 0.83A 2nxeB-1suvE:
undetectable		 2nxeB-1suvE:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 8 LEU A 280
ALA A 271
ILE A 332
GLY A 252
LEU A 375
 None
 1.38A 2o4nB-1suvA:
undetectable		 2o4nB-1suvA:
8.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 LEU E 638
TYR E 647
GLY E 649
 None
 0.48A 2ocuA-1suvE:
50.0		 2ocuA-1suvE:
58.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 448
PHE A 442
GLY A 595
ILE A 482
 None
 0.87A 2qwxA-1suvA:
2.8
2qwxB-1suvA:
2.5		 2qwxA-1suvA:
17.48
2qwxB-1suvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLN A 197
THR A 336
TRP A 412
 None
 1.15A 2rctA-1suvA:
undetectable		 2rctA-1suvA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		6 / 10 LEU A 712
LEU A 625
SER A 638
LEU A 639
LEU A 735
ARG A 732
 None
 1.42A 2xn7A-1suvA:
undetectable
2xn7B-1suvA:
undetectable		 2xn7A-1suvA:
20.19
2xn7B-1suvA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 7 ALA E 583
ASN E 581
PRO E 421
ALA E 409
 None
 1.10A 2zgwA-1suvE:
undetectable		 2zgwA-1suvE:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 6 ALA E 583
ASN E 581
PRO E 421
ALA E 409
 None
 1.11A 2zgwB-1suvE:
undetectable		 2zgwB-1suvE:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.20A 3a50A-1suvA:
undetectable		 3a50A-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.21A 3a50C-1suvA:
undetectable		 3a50C-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.16A 3a50E-1suvA:
undetectable		 3a50E-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.18A 3a51A-1suvA:
undetectable		 3a51A-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.18A 3a51D-1suvA:
undetectable		 3a51D-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 8 ASP A 162
GLY A 158
ALA A 157
ASP A 457
GLY A 462
 None
 1.35A 3em6A-1suvA:
undetectable		 3em6A-1suvA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 TYR E 652
TYR E 425
GLY E 393
 None
FE  E 703 ( 4.1A)
None
 0.72A 3eteB-1suvE:
undetectable
3eteD-1suvE:
undetectable
3eteF-1suvE:
undetectable		 3eteB-1suvE:
22.16
3eteD-1suvE:
22.16
3eteF-1suvE:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 TYR E 652
TYR E 425
GLY E 394
 None
FE  E 703 ( 4.1A)
None
 0.67A 3eteB-1suvE:
undetectable
3eteD-1suvE:
undetectable
3eteF-1suvE:
undetectable		 3eteB-1suvE:
22.16
3eteD-1suvE:
22.16
3eteF-1suvE:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 12 TYR E 395
ILE E 461
GLY E 458
ALA E 452
ALA E 528
 None
None
CO3  E 701 (-4.0A)
None
None
 1.06A 3jayA-1suvE:
undetectable		 3jayA-1suvE:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 482
ALA A 451
ALA A 478
PHE A 597
PRO A 551
 None
 1.08A 3jb1A-1suvA:
undetectable		 3jb1A-1suvA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 701
VAL A 681
LEU A 501
PRO A 500
 None
 0.98A 3jq7C-1suvA:
undetectable		 3jq7C-1suvA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 9 PRO A 444
ILE A 448
VAL A 403
THR A 602
ILE A 599
 None
 1.45A 3p4wA-1suvA:
0.0		 3p4wA-1suvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 176
SER A 434
GLN A 431
 None
 0.90A 3smtA-1suvA:
undetectable		 3smtA-1suvA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 7 GLY E 424
PRO E 580
ASN E 581
TYR E 647
GLY E 649
 None
 0.40A 3tajA-1suvE:
50.3		 3tajA-1suvE:
58.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 5 GLY E 424
PRO E 580
ASN E 581
TYR E 647
 None
 0.42A 3u8qA-1suvE:
50.2		 3u8qA-1suvE:
58.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 165
GLY A 415
GLY A 567
LEU A 147
GLY A 422
 None
 1.05A 4blvA-1suvA:
undetectable		 4blvA-1suvA:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 6 GLY E 424
PRO E 580
GLY E 649
TYR E 652
 None
 0.59A 4dxuA-1suvE:
49.8		 4dxuA-1suvE:
58.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 11 TYR E 514
VAL E 530
SER E 427
TYR E 425
ALA E 579
 CO3  E 701 ( 3.8A)
None
None
FE  E 703 ( 4.1A)
None
 1.19A 4evrA-1suvE:
1.4		 4evrA-1suvE:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 9 GLU E 413
GLY E 424
PRO E 580
TYR E 647
TYR E 652
 None
 1.21A 4fimA-1suvE:
50.0		 4fimA-1suvE:
58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 9 GLY E 424
PRO E 580
TYR E 647
GLY E 649
TYR E 652
 None
 0.49A 4fimA-1suvE:
50.0		 4fimA-1suvE:
58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 6 GLY E 424
PRO E 580
ASN E 581
TYR E 647
GLY E 649
 None
 0.46A 4fjpA-1suvE:
50.0		 4fjpA-1suvE:
58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		5 / 7 GLY E 424
PRO E 580
ASN E 581
TYR E 647
GLY E 649
 None
 0.46A 4forA-1suvE:
50.0		 4forA-1suvE:
58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 PRO E 580
TYR E 647
GLY E 649
 None
 0.38A 4g2zA-1suvE:
50.1		 4g2zA-1suvE:
58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		6 / 7 ILE E 461
LEU E 465
HIS E 575
ALA E 577
TYR E 652
ALA E 655
 None
 0.55A 4g77A-1suvE:
50.3		 4g77A-1suvE:
58.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 405
ALA A 407
LEU A 427
LYS A 428
LEU A 178
 None
 0.64A 4ky8B-1suvA:
undetectable		 4ky8B-1suvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 8 PHE E 478
VAL E 527
ASP E 526
ALA E 429
 None
 0.89A 4m48A-1suvE:
undetectable		 4m48A-1suvE:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 236
ASP A 284
ASP A 562
 None
 0.87A 4obwD-1suvA:
undetectable		 4obwD-1suvA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A 286
THR A 359
ASP A 284
TYR A 282
 None
 1.49A 4oltB-1suvA:
undetectable		 4oltB-1suvA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 405
ALA A 407
LEU A 427
LYS A 428
LEU A 178
 None
 0.54A 4q0dA-1suvA:
undetectable		 4q0dA-1suvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 405
ALA A 407
LEU A 427
LYS A 428
LEU A 178
 None
 0.53A 4q0dB-1suvA:
undetectable		 4q0dB-1suvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 405
ALA A 407
LEU A 427
LYS A 428
LEU A 178
 None
 0.54A 4q0dE-1suvA:
undetectable		 4q0dE-1suvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 433
PHE A 450
LEU A 601
THR A 602
ASP A 604
 None
 1.41A 4qb9E-1suvA:
1.0		 4qb9E-1suvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 448
PHE A 442
GLY A 595
ILE A 482
 None
 0.81A 4qogA-1suvA:
2.4
4qogB-1suvA:
2.6		 4qogA-1suvA:
17.48
4qogB-1suvA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 458
ILE A 384
ALA A 455
THR A 569
SER A 159
 None
 1.21A 4qztC-1suvA:
undetectable		 4qztC-1suvA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 625
ASP A 624
TYR A 643
LEU A 642
 None
 1.23A 4wozF-1suvA:
0.5
4wozH-1suvA:
1.3		 4wozF-1suvA:
17.03
4wozH-1suvA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 457
LEU A 566
GLY A 567
 None
 0.50A 4xmfA-1suvA:
undetectable		 4xmfA-1suvA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 565
THR A 568
THR A 572
 None
 0.77A 5aoxB-1suvA:
undetectable		 5aoxB-1suvA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 565
THR A 568
THR A 572
 None
 0.71A 5aoxE-1suvA:
undetectable		 5aoxE-1suvA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 656
LEU A 501
PHE A 660
LEU A 607
 None
 0.94A 5gtrA-1suvA:
undetectable		 5gtrA-1suvA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		3 / 3 ASP E 392
ASN E 581
PHE E 529
 FE  E 703 ( 3.0A)
None
None
 0.83A 5jglB-1suvE:
undetectable		 5jglB-1suvE:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 429
ALA A 430
PHE A 433
VAL A 598
ILE A 482
 None
 1.03A 5om2A-1suvA:
undetectable
5om2B-1suvA:
undetectable		 5om2A-1suvA:
8.06
5om2B-1suvA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 9 VAL A 405
LEU A 429
ALA A 430
PHE A 433
ILE A 482
 None
 1.10A 5om2A-1suvA:
undetectable
5om2B-1suvA:
undetectable		 5om2A-1suvA:
8.06
5om2B-1suvA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 5 ARG E 469
LEU E 466
PHE E 479
LEU E 443
 None
 1.13A 5x1bP-1suvE:
undetectable		 5x1bP-1suvE:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 457
LEU A 427
SER A 159
THR A 143
GLY A 415
 None
 1.20A 6b0lB-1suvA:
undetectable		 6b0lB-1suvA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 404
ALA A 451
TRP A 453
TYR A 470
LEU A 474
 None
 1.30A 6dk1A-1suvA:
0.0		 6dk1A-1suvA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 404
ALA A 451
TRP A 453
TYR A 470
LEU A 474
 None
 1.31A 6dk1B-1suvA:
0.0		 6dk1B-1suvA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 404
ALA A 451
TRP A 453
TYR A 470
LEU A 474
 None
 1.28A 6dk1C-1suvA:
0.0		 6dk1C-1suvA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens) 		4 / 7 ASP E 625
ARG E 629
GLU E 410
GLU E 413
 None
 1.24A 6mn5B-1suvE:
undetectable		 6mn5B-1suvE:
15.79