SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1suw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 130
VAL A 149
ILE A 220
LEU A 132
 None
 0.92A 1igxA-1suwA:
undetectable		 1igxA-1suwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.32A 1mj2B-1suwA:
undetectable		 1mj2B-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.39A 1mj2D-1suwA:
undetectable		 1mj2D-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.36A 1mjoB-1suwA:
undetectable		 1mjoB-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.35A 1mjoA-1suwA:
undetectable		 1mjoA-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 HIS A  78
ALA A  79
PHE A  84
GLY A  67
 None
 1.35A 1mjoD-1suwA:
undetectable		 1mjoD-1suwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 4 SER A 106
VAL A 111
PHE A 216
VAL A 199
 None
 1.48A 1o86A-1suwA:
0.8		 1o86A-1suwA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 7 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3075 ( 4.2A)
NAP  A3075 ( 4.7A)
None
 0.93A 1ya4B-1suwA:
2.3		 1ya4B-1suwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3075 ( 4.2A)
NAP  A3075 ( 4.7A)
None
 0.94A 1ya4C-1suwA:
2.4		 1ya4C-1suwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A  51
GLY A  48
GLY A  74
LYS A 244
ILE A  55
 None
NAP  A3075 (-3.4A)
NAP  A3075 ( 4.7A)
None
None
 1.38A 2akeA-1suwA:
undetectable		 2akeA-1suwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A  42
ILE A  43
LEU A  37
LEU A  20
PHE A  30
 None
 1.11A 2jn3A-1suwA:
undetectable		 2jn3A-1suwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 8 ILE A 220
ILE A 222
ILE A 148
ARG A 102
VAL A 103
 None
 1.42A 2nniA-1suwA:
undetectable		 2nniA-1suwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 6 LEU A  75
LEU A  76
ASP A  49
ILE A 248
 NAP  A3075 ( 4.2A)
None
NAP  A3075 (-4.2A)
None
 0.98A 2rlfB-1suwA:
undetectable
2rlfC-1suwA:
undetectable		 2rlfB-1suwA:
14.69
2rlfC-1suwA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  81
THR A  70
GLY A  47
GLY A  48
THR A  51
 None
None
None
NAP  A3075 (-3.4A)
None
 1.21A 2uvnA-1suwA:
undetectable		 2uvnA-1suwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 5 VAL A   6
VAL A   5
PHE A 231
ARG A  15
 None
 1.39A 3bjwB-1suwA:
0.0		 3bjwB-1suwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 178
ILE A 177
PRO A 188
TYR A 189
 None
 1.19A 3d9lA-1suwA:
undetectable
3d9lY-1suwA:
undetectable		 3d9lA-1suwA:
20.08
3d9lY-1suwA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
 None
 1.11A 4aztA-1suwA:
undetectable		 4aztA-1suwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 197
LEU A 132
ILE A 175
GLY A 146
 None
 0.82A 4hb8A-1suwA:
undetectable		 4hb8A-1suwA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  74
LEU A 241
ILE A  52
THR A  77
GLY A  67
 NAP  A3075 ( 4.7A)
None
None
None
None
 1.09A 5d4uA-1suwA:
undetectable		 5d4uA-1suwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  74
LEU A 241
ILE A  52
THR A  77
GLY A  67
 NAP  A3075 ( 4.7A)
None
None
None
None
 1.09A 5d4uB-1suwA:
undetectable		 5d4uB-1suwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A 234
HIS A  78
ASP A  49
GLY A  48
 None
None
NAP  A3075 (-4.2A)
NAP  A3075 (-3.4A)
 1.08A 5x7pA-1suwA:
undetectable		 5x7pA-1suwA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.13A 6ebpA-1suwA:
undetectable		 6ebpA-1suwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.12A 6ebpB-1suwA:
undetectable		 6ebpB-1suwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.10A 6ebpC-1suwA:
undetectable		 6ebpC-1suwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  76
THR A  77
SER A  45
GLY A  47
ILE A  65
 None
 1.11A 6ebpD-1suwA:
undetectable		 6ebpD-1suwA:
12.15