SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 ALA A 129
VAL A 111
TRP A 132
 None
 0.86A 1c4dC-1sv6A:
undetectable
1c4dD-1sv6A:
undetectable		 1c4dC-1sv6A:
7.01
1c4dD-1sv6A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		4 / 5 LEU A 222
GLU A 220
ALA A 216
LEU A 116
 None
 1.04A 1eta1-1sv6A:
1.3		 1eta1-1sv6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		4 / 5 LEU A 222
GLU A 220
ALA A 216
LEU A 116
 None
 1.10A 1eta2-1sv6A:
0.0		 1eta2-1sv6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		4 / 6 LEU A 222
GLU A 220
ALA A 216
LEU A 116
 None
 1.04A 1etb1-1sv6A:
1.4		 1etb1-1sv6A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 GLN A  71
THR A 154
TRP A 147
 None
 1.18A 2rctA-1sv6A:
undetectable		 2rctA-1sv6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		5 / 8 ILE A 108
VAL A 255
GLY A 167
GLY A 253
GLN A 171
 None
 0.89A 2wd9B-1sv6A:
undetectable		 2wd9B-1sv6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		5 / 10 ILE A 108
VAL A 255
GLY A 167
GLY A 253
GLN A 171
 None
 0.92A 2wd9C-1sv6A:
undetectable		 2wd9C-1sv6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 LEU A 176
GLU A 250
ILE A 249
 None
 0.52A 3czhA-1sv6A:
undetectable		 3czhA-1sv6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 LEU A  29
LEU A  26
ARG A 145
 None
 0.63A 3hcnB-1sv6A:
undetectable		 3hcnB-1sv6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 GLU A 138
LEU A 229
LEU A 201
 None
 0.63A 3ohtA-1sv6A:
undetectable		 3ohtA-1sv6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 GLU A 138
LEU A 229
LEU A 201
 None
 0.61A 3ohtB-1sv6A:
undetectable		 3ohtB-1sv6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		5 / 10 ALA A 109
LEU A 205
LEU A 112
ILE A 130
ALA A 129
 None
 1.19A 3r9cA-1sv6A:
undetectable		 3r9cA-1sv6A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 GLN A  52
HIS A  48
ARG A  14
 None
 1.17A 4qyqA-1sv6A:
0.0		 4qyqA-1sv6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		3 / 3 GLN A  52
HIS A  48
ARG A  14
 None
 1.21A 4qyqB-1sv6A:
undetectable		 4qyqB-1sv6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1sv6 2-KETO-4-PENTENOATE
HYDRATASE
(Escherichia
coli) 		4 / 6 ASN A 240
ALA A 241
PRO A 102
VAL A 239
 None
 0.99A 5umd2-1sv6A:
undetectable
5umdF-1sv6A:
undetectable		 5umd2-1sv6A:
13.01
5umdF-1sv6A:
16.29