SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1svc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 5 TYR P 166
PRO P 234
LEU P  45
THR P 127
 None
 1.36A 1i2wA-1svcP:
undetectable		 1i2wA-1svcP:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 8 GLY P 183
LEU P 189
ARG P 164
GLY P 185
 None
 0.73A 1jhvA-1svcP:
undetectable		 1jhvA-1svcP:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 THR P 159
GLY P 183
LEU P 189
ARG P 164
GLY P 185
 None
 1.09A 1jhyA-1svcP:
undetectable		 1jhyA-1svcP:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 THR P 159
GLY P 183
LEU P 189
ARG P 164
GLY P 185
 None
 1.09A 1l4nA-1svcP:
undetectable		 1l4nA-1svcP:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.41A 1ncwH-1svcP:
6.0
1ncwL-1svcP:
3.2		 1ncwH-1svcP:
21.74
1ncwL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.44A 1ru9H-1svcP:
2.3
1ru9L-1svcP:
2.4		 1ru9H-1svcP:
21.74
1ru9L-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 10 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.42A 1ruaH-1svcP:
3.2
1ruaL-1svcP:
3.3		 1ruaH-1svcP:
21.74
1ruaL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 8 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.43A 1rukH-1svcP:
5.8
1rukL-1svcP:
3.3		 1rukH-1svcP:
21.74
1rukL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.47A 1rulH-1svcP:
2.0
1rulL-1svcP:
2.9		 1rulH-1svcP:
21.74
1rulL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.40A 1rumH-1svcP:
6.0
1rumL-1svcP:
3.5		 1rumH-1svcP:
21.74
1rumL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 ALA P 138
TYR P  82
LEU P 140
GLY P 116
GLY P  68
 None
 1.42A 1rupH-1svcP:
6.1
1rupL-1svcP:
2.9		 1rupH-1svcP:
21.74
1rupL-1svcP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 8 PRO P  83
LEU P 140
GLY P 141
LEU P 215
 None
 0.93A 1ya4A-1svcP:
undetectable		 1ya4A-1svcP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 6 ILE P 253
SER P 343
ARG P 284
PHE P 314
 None
 0.91A 2q72A-1svcP:
undetectable		 2q72A-1svcP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 7 ILE P 253
SER P 343
ARG P 284
PHE P 314
 None
 0.93A 2qb4A-1svcP:
undetectable		 2qb4A-1svcP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 8 PHE P 348
ILE P 269
PHE P 285
GLY P 266
 None
 0.87A 2qwxA-1svcP:
undetectable
2qwxB-1svcP:
undetectable		 2qwxA-1svcP:
20.71
2qwxB-1svcP:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 8 PHE P 348
ILE P 269
PHE P 285
GLY P 266
 None
 0.87A 2qx4A-1svcP:
undetectable
2qx4B-1svcP:
undetectable		 2qx4A-1svcP:
21.25
2qx4B-1svcP:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		5 / 9 GLY P  72
PRO P  83
GLY P  55
ILE P 142
PHE P 217
 None
 1.33A 3ko0H-1svcP:
undetectable
3ko0I-1svcP:
undetectable		 3ko0H-1svcP:
15.82
3ko0I-1svcP:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 8 PHE P 348
ILE P 269
PHE P 285
GLY P 266
 None
 0.88A 4qogA-1svcP:
undetectable
4qogB-1svcP:
undetectable		 4qogA-1svcP:
20.71
4qogB-1svcP:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		4 / 5 ALA P 128
ALA P  94
ILE P  87
LEU P  45
 None
 0.82A 5jncD-1svcP:
undetectable		 5jncD-1svcP:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))
(Homo
sapiens) 		3 / 3 ARG P  59
ILE P 142
PHE P  58
 None
 0.64A 5kirA-1svcP:
undetectable		 5kirA-1svcP:
20.57