SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1svv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1svv THREONINE ALDOLASE
(Leishmania
major) 		3 / 3 LEU A 191
SER A 193
ASN A 298
 None
 0.77A 1bx4A-1svvA:
3.7		 1bx4A-1svvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 1.02A 1c6zA-1svvA:
undetectable		 1c6zA-1svvA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 0.99A 1c6zB-1svvA:
undetectable		 1c6zB-1svvA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 THR A  40
ASP A  37
HIS A  50
HIS A  42
 UNL  A 401 ( 4.2A)
UNL  A 401 (-1.9A)
UNL  A 401 (-3.4A)
UNL  A 401 (-3.0A)
 1.18A 1ei6A-1svvA:
undetectable		 1ei6A-1svvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 11 ASN A 306
GLY A 327
ILE A 289
ILE A 330
ILE A 309
 None
 0.96A 1n49B-1svvA:
undetectable		 1n49B-1svvA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 6 THR A 339
GLU A 343
PHE A 347
ILE A 279
 None
 1.31A 2w98B-1svvA:
undetectable		 2w98B-1svvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 VAL A  69
ILE A 226
LEU A 260
GLY A 213
ALA A 214
 None
 1.24A 2xf3A-1svvA:
undetectable		 2xf3A-1svvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 VAL A  69
ILE A 226
LEU A 260
GLY A 213
ALA A 214
 None
 1.23A 2xf3B-1svvA:
0.0		 2xf3B-1svvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 VAL A  69
ILE A 226
LEU A 260
GLY A 213
ALA A 214
 None
 1.23A 2xfsB-1svvA:
0.0		 2xfsB-1svvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 VAL A  69
ILE A 226
LEU A 260
GLY A 213
ALA A 214
 None
 1.22A 2xh9B-1svvA:
0.0		 2xh9B-1svvA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ILE A 212
GLY A  74
GLY A 222
ALA A 224
LEU A 225
 None
 0.93A 2yvlA-1svvA:
undetectable		 2yvlA-1svvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ILE A 212
GLY A  74
GLY A 222
ALA A 224
LEU A 225
 None
 0.96A 2yvlB-1svvA:
2.2		 2yvlB-1svvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 ILE A 109
MET A 209
LEU A  87
LEU A 148
 None
 1.15A 2zb7A-1svvA:
2.1		 2zb7A-1svvA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 8 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 1.12A 3ekpA-1svvA:
undetectable		 3ekpA-1svvA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 1.03A 3ektA-1svvA:
undetectable		 3ektA-1svvA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASN A 153
THR A 155
LEU A 206
ILE A 169
THR A 207
 None
 1.44A 3elzC-1svvA:
undetectable		 3elzC-1svvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 7 LYS A 125
ASN A 153
ASN A 274
ALA A 188
 None
 1.42A 3frqB-1svvA:
undetectable		 3frqB-1svvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 7 LYS A 125
ASN A 153
ASN A 298
ALA A 188
 None
 1.31A 3frqB-1svvA:
undetectable		 3frqB-1svvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 GLU A 105
GLU A 223
ALA A 214
ASP A 183
GLY A 184
 None
 1.33A 3jzjA-1svvA:
undetectable		 3jzjA-1svvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 7 TYR A 161
LEU A 198
SER A 152
ASN A 153
 None
 1.00A 3lm8A-1svvA:
undetectable
3lm8C-1svvA:
undetectable		 3lm8A-1svvA:
23.90
3lm8C-1svvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 8 TYR A 161
LEU A 198
SER A 152
ASN A 153
 None
 1.04A 3lm8B-1svvA:
undetectable
3lm8D-1svvA:
undetectable		 3lm8B-1svvA:
23.90
3lm8D-1svvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.97A 3lzvA-1svvA:
undetectable		 3lzvA-1svvA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 1.09A 3n3iA-1svvA:
undetectable		 3n3iA-1svvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 1.06A 3ndwA-1svvA:
undetectable		 3ndwA-1svvA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 4 TYR A 150
TYR A 211
GLU A 223
GLY A  75
 None
 1.34A 3reqA-1svvA:
4.7		 3reqA-1svvA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		6 / 9 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
ILE A 101
 None
 1.05A 3s53A-1svvA:
undetectable		 3s53A-1svvA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 7 THR A  40
ASP A  37
HIS A  50
HIS A  42
 UNL  A 401 ( 4.2A)
UNL  A 401 (-1.9A)
UNL  A 401 (-3.4A)
UNL  A 401 (-3.0A)
 1.06A 3t01A-1svvA:
undetectable		 3t01A-1svvA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 SER A 295
GLY A 158
TRP A 293
ASP A 123
 None
 1.41A 3w9tB-1svvA:
0.0		 3w9tB-1svvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 SER A 295
GLY A 158
TRP A 293
ASP A 123
 None
 1.42A 3w9tC-1svvA:
undetectable		 3w9tC-1svvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 SER A 295
GLY A 158
TRP A 293
ASP A 123
 None
 1.41A 3w9tD-1svvA:
0.0		 3w9tD-1svvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 6 THR A 154
ASN A 153
GLY A 184
ASP A 183
 None
 1.37A 3w9tE-1svvA:
undetectable		 3w9tE-1svvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 1.00A 4dqbB-1svvA:
undetectable		 4dqbB-1svvA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.98A 4dqeB-1svvA:
undetectable		 4dqeB-1svvA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.98A 4dqhB-1svvA:
undetectable		 4dqhB-1svvA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 THR A 118
THR A 103
GLU A 105
SER A 152
ASP A 130
 None
 1.48A 4njgB-1svvA:
0.8		 4njgB-1svvA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.98A 4njtB-1svvA:
undetectable		 4njtB-1svvA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.99A 4q1wA-1svvA:
undetectable		 4q1wA-1svvA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 10 GLY A 270
PHE A 266
LEU A 260
ALA A 214
ALA A 185
 None
 1.26A 4wnuD-1svvA:
undetectable		 4wnuD-1svvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		3 / 3 TYR A  22
ARG A 186
LYS A 216
 None
 0.78A 4wq5B-1svvA:
undetectable		 4wq5B-1svvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 9 LEU A 265
GLY A 219
ALA A 214
GLY A 254
ILE A 255
 None
 0.92A 5kr0B-1svvA:
undetectable		 5kr0B-1svvA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 ASP A 183
GLY A 184
ALA A 185
GLY A  74
ILE A  72
 None
 1.08A 5t2zA-1svvA:
undetectable		 5t2zA-1svvA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		5 / 12 PHE A 266
ALA A 190
LEU A 182
MET A 209
THR A  76
 None
 1.16A 5tl8A-1svvA:
undetectable		 5tl8A-1svvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 LEU A 232
LYS A 233
ALA A 236
LEU A 239
 None
 0.85A 5vkqA-1svvA:
0.0
5vkqD-1svvA:
0.0		 5vkqA-1svvA:
12.70
5vkqD-1svvA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 LEU A 232
LYS A 233
ALA A 236
LEU A 239
 None
 0.84A 5vkqA-1svvA:
0.0
5vkqB-1svvA:
0.0		 5vkqA-1svvA:
12.70
5vkqB-1svvA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 LEU A 232
LYS A 233
ALA A 236
LEU A 239
 None
 0.84A 5vkqB-1svvA:
0.0
5vkqC-1svvA:
0.0		 5vkqB-1svvA:
12.70
5vkqC-1svvA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1svv THREONINE ALDOLASE
(Leishmania
major) 		4 / 5 LEU A 232
LYS A 233
ALA A 236
LEU A 239
 None
 0.84A 5vkqC-1svvA:
undetectable
5vkqD-1svvA:
undetectable		 5vkqC-1svvA:
12.70
5vkqD-1svvA:
12.70