SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1svx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		4 / 7 ASN A  45
THR A  49
GLY A  47
ASP A  77
 None
 1.01A 1bu5A-1svxA:
undetectable		 1bu5A-1svxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		4 / 8 SER A 111
THR A  48
ASP A  44
ASN A  45
 None
 1.11A 1lhvA-1svxA:
undetectable		 1lhvA-1svxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 11 ALA A  71
HIS A  52
GLU A  64
ALA A  55
LEU A  99
 None
 1.32A 1mjlA-1svxA:
undetectable
1mjlB-1svxA:
undetectable		 1mjlA-1svxA:
17.58
1mjlB-1svxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 11 ALA A  71
HIS A  52
GLU A  64
LEU A  60
LEU A  99
 None
 1.17A 1mjlA-1svxA:
undetectable
1mjlB-1svxA:
undetectable		 1mjlA-1svxA:
17.58
1mjlB-1svxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		4 / 7 ARG A  16
ALA A  21
PRO A  50
ALA A  22
 None
 0.81A 2ejfA-1svxA:
undetectable		 2ejfA-1svxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 12 ILE A 128
GLY A 124
ILE A 152
ASN A 107
LEU A 165
 None
 1.07A 4a81A-1svxA:
undetectable		 4a81A-1svxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 0.95A 4p65B-1svxA:
undetectable
4p65D-1svxA:
undetectable
4p65I-1svxA:
undetectable
4p65J-1svxA:
undetectable		 4p65B-1svxA:
12.00
4p65D-1svxA:
12.00
4p65I-1svxA:
6.59
4p65J-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 12 VAL A  96
LEU A  84
LEU A 117
ILE A 128
ALA A 137
 None
 1.01A 4p65B-1svxA:
undetectable
4p65D-1svxA:
undetectable
4p65I-1svxA:
undetectable
4p65J-1svxA:
undetectable		 4p65B-1svxA:
12.00
4p65D-1svxA:
12.00
4p65I-1svxA:
6.59
4p65J-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 12 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 0.99A 4p65F-1svxA:
undetectable
4p65H-1svxA:
undetectable
4p65K-1svxA:
undetectable
4p65L-1svxA:
undetectable		 4p65F-1svxA:
12.00
4p65H-1svxA:
12.00
4p65K-1svxA:
6.59
4p65L-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 12 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-1svxA:
undetectable
4p65H-1svxA:
undetectable
4p65K-1svxA:
undetectable
4p65L-1svxA:
undetectable		 4p65F-1svxA:
12.00
4p65H-1svxA:
12.00
4p65K-1svxA:
6.59
4p65L-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1svx ANKYRIN REPEAT
PROTEIN OFF7
(-) 		5 / 9 PRO A  83
MET A  34
VAL A  30
ILE A  62
TYR A  56
 None
 1.16A 5iepA-1svxA:
undetectable		 5iepA-1svxA:
24.22