SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1svz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		4 / 6 TYR A 230
ASP A 229
THR A 235
GLU A 232
 None
 1.46A 2dttB-1svzA:
0.0
2dttC-1svzA:
0.0		 2dttB-1svzA:
15.98
2dttC-1svzA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		5 / 10 HIS A  31
TYR A  37
PHE A  94
GLY A  96
HIS A 162
 None
 0.58A 2pcpC-1svzA:
23.0
2pcpD-1svzA:
15.2		 2pcpC-1svzA:
54.66
2pcpD-1svzA:
50.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		6 / 12 HIS A 162
VAL A 164
TRP A 177
TRP A 237
TYR A  37
GLU A  39
 None
 0.83A 3wfhA-1svzA:
15.9
3wfhB-1svzA:
23.8		 3wfhA-1svzA:
23.77
3wfhB-1svzA:
53.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		6 / 12 HIS A 162
VAL A 164
TRP A 237
HIS A  31
TYR A  37
GLU A  39
 None
 0.84A 3wfhA-1svzA:
15.9
3wfhB-1svzA:
23.8		 3wfhA-1svzA:
23.77
3wfhB-1svzA:
53.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		5 / 12 HIS A 162
VAL A 164
TRP A 177
TRP A 237
GLU A  39
 None
 0.80A 3whxA-1svzA:
16.0
3whxB-1svzA:
23.8		 3whxA-1svzA:
23.77
3whxB-1svzA:
53.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		6 / 12 HIS A 162
VAL A 164
TRP A 237
HIS A  31
TYR A  37
GLU A  39
 None
 0.87A 3whxA-1svzA:
16.0
3whxB-1svzA:
23.8		 3whxA-1svzA:
23.77
3whxB-1svzA:
53.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		4 / 8 ILE A 147
PRO A  49
VAL A 224
TRP A 237
 None
 1.18A 4f4dB-1svzA:
undetectable		 4f4dB-1svzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		4 / 5 VAL A 129
TYR A 154
ARG A 225
TYR A 236
 None
 0.38A 4m7kH-1svzA:
15.6		 4m7kH-1svzA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		5 / 12 HIS A 162
PHE A 234
GLN A  95
GLY A  96
PRO A 101
 None
 0.91A 4uilH-1svzA:
14.8
4uilL-1svzA:
19.0		 4uilH-1svzA:
27.27
4uilL-1svzA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1svz SINGLE-CHAIN FV
FRAGMENT 1696
(Mus
musculus) 		4 / 5 ILE A 233
PHE A 234
TYR A 174
THR A 186
 None
 1.15A 5z84N-1svzA:
undetectable
5z84W-1svzA:
undetectable		 5z84N-1svzA:
19.08
5z84W-1svzA:
11.34