SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 250
SER A 342
LEU A 296
LEU A 254
 None
 1.08A 1yajD-1sw6A:
undetectable		 1yajD-1sw6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 415
LEU A 355
LEU A 383
LEU A 374
 None
 1.16A 1yajD-1sw6A:
undetectable		 1yajD-1sw6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 393
ILE A 391
LEU A 412
 None
 0.77A 2kceA-1sw6A:
undetectable		 2kceA-1sw6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 322
PRO A 321
LEU A 325
 None
 0.61A 2po5B-1sw6A:
undetectable		 2po5B-1sw6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 230
LEU A 453
ILE A 382
LEU A 345
ASP A 220
 None
 1.22A 2q72A-1sw6A:
0.0		 2q72A-1sw6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 230
LEU A 453
ILE A 382
LEU A 345
ASP A 220
 None
 1.23A 2qeiA-1sw6A:
0.0		 2qeiA-1sw6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 253
GLN A 246
PHE A 292
 None
 0.76A 3rv5A-1sw6A:
0.0		 3rv5A-1sw6A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 427
LEU A 450
ILE A 214
ASP A 375
 None
 0.87A 4dtaB-1sw6A:
undetectable		 4dtaB-1sw6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 498
LEU A 480
LEU A 489
ILE A 485
 None
 0.74A 4r38A-1sw6A:
undetectable		 4r38A-1sw6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 498
LEU A 480
LEU A 489
ILE A 485
 None
 0.78A 4r38D-1sw6A:
undetectable		 4r38D-1sw6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 338
TYR A 376
ASN A 363
HIS A 323
ASP A 348
 None
 1.34A 5fhqA-1sw6A:
0.0		 5fhqA-1sw6A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 412
LEU A 415
GLY A 417
VAL A 420
LEU A 463
 None
 0.87A 5uc1A-1sw6A:
undetectable		 5uc1A-1sw6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 412
LEU A 415
GLY A 417
VAL A 420
LEU A 463
 None
 0.85A 5uc1B-1sw6A:
undetectable		 5uc1B-1sw6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sw6 REGULATORY PROTEIN
SWI6
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 449
LEU A 221
MET A 233
LEU A 383
 None
 0.94A 5xdqN-1sw6A:
0.0
5xdqW-1sw6A:
undetectable		 5xdqN-1sw6A:
19.15
5xdqW-1sw6A:
14.45