SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD8_0
(GRAMICIDIN D)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 4 VAL A 194
TRP A 241
VAL A 198
TRP A 189
 None
 1.42A 2izqC-1sxdA:
undetectable
2izqD-1sxdA:
undetectable		 2izqC-1sxdA:
11.76
2izqD-1sxdA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 5 SER A 254
ARG A 220
GLY A 219
GLU A 221
 None
 1.34A 3k9fA-1sxdA:
0.4
3k9fB-1sxdA:
0.4
3k9fC-1sxdA:
undetectable		 3k9fA-1sxdA:
11.88
3k9fB-1sxdA:
11.88
3k9fC-1sxdA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA8_0
(GRAMICIDIN D)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 4 VAL A 198
TRP A 189
VAL A 194
TRP A 241
 None
 1.34A 3l8lA-1sxdA:
undetectable
3l8lB-1sxdA:
undetectable		 3l8lA-1sxdA:
11.76
3l8lB-1sxdA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		5 / 6 LEU A 247
TYR A 250
ALA A 253
ARG A 248
LEU A 170
 None
 1.27A 3ravA-1sxdA:
undetectable		 3ravA-1sxdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 6 ARG A 233
ILE A 210
VAL A 198
LEU A 195
 None
 0.86A 4em2A-1sxdA:
undetectable		 4em2A-1sxdA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		3 / 3 ARG A 248
LEU A 244
GLU A 245
 None
 0.67A 4l3gF-1sxdA:
undetectable		 4l3gF-1sxdA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 7 ALA A 253
ARG A 220
GLY A 219
GLU A 221
 None
 0.82A 5bs8A-1sxdA:
undetectable
5bs8C-1sxdA:
undetectable
5bs8D-1sxdA:
undetectable		 5bs8A-1sxdA:
9.72
5bs8C-1sxdA:
9.72
5bs8D-1sxdA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 7 ALA A 253
ARG A 220
GLY A 219
GLU A 221
 None
 0.79A 5bs8A-1sxdA:
undetectable
5bs8B-1sxdA:
undetectable
5bs8C-1sxdA:
undetectable		 5bs8A-1sxdA:
9.72
5bs8B-1sxdA:
17.92
5bs8C-1sxdA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1sxd GA REPEAT BINDING
PROTEIN, ALPHA
(Mus
musculus) 		4 / 6 ALA A 253
ARG A 220
GLY A 219
GLU A 221
 None
 0.80A 5btgA-1sxdA:
0.1
5btgB-1sxdA:
undetectable
5btgC-1sxdA:
0.1		 5btgA-1sxdA:
9.72
5btgB-1sxdA:
17.92
5btgC-1sxdA:
9.72