SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP C  87
ARG D 107
ILE D 103
 None
 0.64A 1a4gB-1sxjC:
undetectable		 1a4gB-1sxjC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 8 ARG B 285
LEU B 286
ALA A 653
GLY A 561
ILE A 563
 None
 1.30A 1d4sB-1sxjB:
undetectable		 1d4sB-1sxjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU E 146
LEU D 139
SER D 144
THR D 146
 None
 0.91A 1dvtA-1sxjE:
undetectable
1dvtB-1sxjE:
undetectable		 1dvtA-1sxjE:
17.15
1dvtB-1sxjE:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.17A 1dz8A-1sxjD:
0.0		 1dz8A-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.15A 1dz8B-1sxjD:
0.0		 1dz8B-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 192
GLY D  70
THR D  74
VAL D  46
ASP D  43
 None
AGS  D 804 (-3.0A)
None
None
None
 1.16A 1dz9B-1sxjD:
0.0		 1dz9B-1sxjD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 363
LEU A 453
LEU A 351
ALA A 349
 None
 0.78A 1e7cA-1sxjA:
undetectable		 1e7cA-1sxjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.81A 1errB-1sxjB:
undetectable		 1errB-1sxjB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 474
ILE A 422
HIS A 364
 None
 0.58A 1fm9A-1sxjA:
0.0		 1fm9A-1sxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 VAL D 275
GLY D 278
THR E 315
ILE D 283
 None
 0.82A 1gtnC-1sxjD:
undetectable
1gtnD-1sxjD:
undetectable		 1gtnC-1sxjD:
14.74
1gtnD-1sxjD:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 382
VAL A 426
MET A 350
ARG A 434
 None
 1.10A 1iepA-1sxjA:
undetectable		 1iepA-1sxjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ARG B 285
LEU B 286
ALA A 653
GLY A 658
GLY A 561
 None
 1.09A 1k6cA-1sxjB:
undetectable		 1k6cA-1sxjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 474
ILE A 422
HIS A 364
 None
 0.59A 1k74A-1sxjA:
0.0		 1k74A-1sxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU B 132
ILE B 151
GLN B 125
ALA A 379
ARG A 515
 AGS  A 801 (-3.9A)
None
None
None
AGS  A 801 (-3.5A)
 1.22A 1ki7B-1sxjB:
undetectable		 1ki7B-1sxjB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ILE B 206
LEU B 209
VAL B 213
 None
 0.21A 1mz9B-1sxjB:
undetectable		 1mz9B-1sxjB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ILE D 341
LEU D 344
VAL D 348
 None
 0.37A 1mz9B-1sxjD:
undetectable		 1mz9B-1sxjD:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.12A 1odiA-1sxjB:
undetectable		 1odiA-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.18A 1odiB-1sxjB:
undetectable		 1odiB-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.15A 1odiC-1sxjB:
undetectable		 1odiC-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.17A 1odiD-1sxjB:
undetectable		 1odiD-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.20A 1odiE-1sxjB:
undetectable		 1odiE-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.19A 1odiF-1sxjB:
undetectable		 1odiF-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 659
ARG A 600
ILE A 592
HIS A 556
 None
 1.43A 1osvB-1sxjA:
0.0		 1osvB-1sxjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 GLY B 122
GLN B 124
VAL B  89
ALA B 126
 None
 0.87A 1p6kA-1sxjB:
undetectable		 1p6kA-1sxjB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ARG C 131
GLY B  54
GLU C 135
ILE B  23
 AGS  B 802 ( 2.7A)
AGS  B 802 (-3.2A)
None
AGS  B 802 (-4.4A)
 0.85A 1pk7B-1sxjC:
undetectable		 1pk7B-1sxjC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLU A 628
ASN E 336
TRP A 669
 None
 1.19A 1r15C-1sxjA:
undetectable		 1r15C-1sxjA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLU A 628
ASN E 336
TRP A 669
 None
 1.25A 1r15D-1sxjA:
undetectable		 1r15D-1sxjA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLU A 628
ASN E 336
TRP A 669
 None
 1.23A 1r15E-1sxjA:
undetectable		 1r15E-1sxjA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 THR B 120
GLY A 432
ASP A 433
ALA A 379
 None
 1.09A 1sg9A-1sxjB:
3.3		 1sg9A-1sxjB:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.02A 1v54A-1sxjE:
2.7
1v54J-1sxjE:
undetectable		 1v54A-1sxjE:
19.27
1v54J-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PHE D 187
LEU D  82
PHE D  63
MET D  61
 None
 1.18A 1wrlE-1sxjD:
2.2		 1wrlE-1sxjD:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE D 189
ALA D  45
LEU D  36
LEU D  49
SER D 185
 None
 1.26A 1xdkB-1sxjD:
undetectable		 1xdkB-1sxjD:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 LEU E 230
SER E  17
LEU E 202
LEU E 234
 ADP  E 805 (-4.3A)
ADP  E 805 (-2.7A)
None
ADP  E 805 (-4.3A)
 1.07A 1yajA-1sxjE:
3.2		 1yajA-1sxjE:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 352
GLY A 342
PHE A 346
SER A 343
 None
 1.19A 2a3cA-1sxjA:
undetectable		 2a3cA-1sxjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 352
GLY A 342
PHE A 346
SER A 343
 None
 1.16A 2a3cB-1sxjA:
undetectable		 2a3cB-1sxjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 SER D 323
LEU C 299
LEU C 248
LEU C 252
 None
 0.96A 2bfpB-1sxjD:
undetectable		 2bfpB-1sxjD:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU E 343
GLY E 344
ARG E 331
CYH E 351
ALA A 615
 None
 1.14A 2bm9A-1sxjE:
undetectable		 2bm9A-1sxjE:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B  55
ASP A 586
ASN B 145
 AGS  B 802 (-2.5A)
None
AGS  B 802 (-3.1A)
 1.12A 2bm9A-1sxjB:
2.5		 2bm9A-1sxjB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 VAL E 116
LEU E  36
ILE E  60
LEU E  57
 None
 0.95A 2byoA-1sxjE:
undetectable		 2byoA-1sxjE:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.01A 2dyrA-1sxjE:
2.7
2dyrJ-1sxjE:
undetectable		 2dyrA-1sxjE:
19.27
2dyrJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.00A 2dysA-1sxjE:
2.6
2dysJ-1sxjE:
undetectable		 2dysA-1sxjE:
19.27
2dysJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 0.98A 2dysN-1sxjE:
2.6
2dysW-1sxjE:
undetectable		 2dysN-1sxjE:
19.27
2dysW-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.00A 2eijA-1sxjE:
2.7
2eijJ-1sxjE:
undetectable		 2eijA-1sxjE:
19.27
2eijJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 0.98A 2eikA-1sxjE:
undetectable
2eikJ-1sxjE:
undetectable		 2eikA-1sxjE:
19.27
2eikJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.01A 2eilA-1sxjE:
3.0
2eilJ-1sxjE:
undetectable		 2eilA-1sxjE:
19.27
2eilJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.21A 2f162-1sxjA:
undetectable		 2f162-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.21A 2f16N-1sxjA:
undetectable		 2f16N-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.75A 2jfaA-1sxjB:
undetectable		 2jfaA-1sxjB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 7 LEU D 168
LEU D  62
PRO C  55
GLU C 118
ARG D 154
 None
None
AGS  C 803 (-4.1A)
AGS  C 803 ( 4.9A)
AGS  C 803 (-4.6A)
 1.46A 2jn3A-1sxjD:
undetectable		 2jn3A-1sxjD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 8 ARG B 285
LEU B 286
ALA A 653
GLY A 561
ILE A 563
 None
 1.18A 2o4nB-1sxjB:
undetectable		 2o4nB-1sxjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU E 219
ALA E 223
ILE E 198
SER E 233
 None
 1.11A 2othA-1sxjE:
undetectable		 2othA-1sxjE:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU D 344
VAL D 348
LYS D 349
ILE D 283
 None
 0.73A 2piwA-1sxjD:
undetectable		 2piwA-1sxjD:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ILE B  47
PRO B  17
LEU B  20
ILE B  23
 None
AGS  B 802 (-4.4A)
None
AGS  B 802 (-4.4A)
 0.87A 2q83A-1sxjB:
2.0		 2q83A-1sxjB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ILE B  47
PRO B  17
LEU B  20
ILE B  23
 None
AGS  B 802 (-4.4A)
None
AGS  B 802 (-4.4A)
 0.83A 2q83B-1sxjB:
2.8		 2q83B-1sxjB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU E 167
PRO E  98
SER E 145
VAL E 108
 None
 1.20A 2qd2A-1sxjE:
undetectable		 2qd2A-1sxjE:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.82A 2qxsA-1sxjB:
undetectable		 2qxsA-1sxjB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.82A 2qxsB-1sxjB:
undetectable		 2qxsB-1sxjB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ILE B  93
LEU B  78
ARG B  90
GLY B  85
 None
 0.97A 2vdbA-1sxjB:
0.0		 2vdbA-1sxjB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 345
TRP A 327
TRP A 323
 None
 1.46A 2xdcC-1sxjA:
undetectable
2xdcD-1sxjA:
undetectable		 2xdcC-1sxjA:
3.27
2xdcD-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 323
VAL A 345
TRP A 327
 None
 1.30A 2xdcC-1sxjA:
undetectable
2xdcD-1sxjA:
undetectable		 2xdcC-1sxjA:
3.27
2xdcD-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 323
VAL A 345
TRP A 327
 None
 1.30A 2xdcE-1sxjA:
undetectable
2xdcF-1sxjA:
undetectable		 2xdcE-1sxjA:
3.27
2xdcF-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 248
ILE C 281
LEU C 285
LEU C 252
 None
 0.79A 2xfhA-1sxjC:
undetectable		 2xfhA-1sxjC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU E 279
GLY E 344
ALA E 347
LYS E 348
 None
 0.69A 2xfsA-1sxjE:
undetectable		 2xfsA-1sxjE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU E 279
GLY E 344
ALA E 347
LYS E 348
 None
 0.71A 2xh9A-1sxjE:
undetectable		 2xh9A-1sxjE:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 323
VAL A 345
TRP A 327
 None
 1.32A 2y5mE-1sxjA:
undetectable
2y5mF-1sxjA:
undetectable		 2y5mE-1sxjA:
3.27
2y5mF-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 323
VAL A 345
TRP A 327
 None
 1.30A 2y6nC-1sxjA:
undetectable
2y6nD-1sxjA:
undetectable		 2y6nC-1sxjA:
3.27
2y6nD-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 323
VAL A 345
TRP A 327
 None
 1.31A 2y6nE-1sxjA:
undetectable
2y6nF-1sxjA:
undetectable		 2y6nE-1sxjA:
3.27
2y6nF-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ASP D 266
ILE D 267
GLN D 303
GLU D 257
 None
 1.20A 2ya7C-1sxjD:
undetectable		 2ya7C-1sxjD:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 TRP B 257
TYR C 149
GLY B 302
ILE B 299
 None
 0.82A 2zm9A-1sxjB:
0.0		 2zm9A-1sxjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER E 183
GLU D 141
ASP D  99
 None
MG  D 814 (-3.4A)
None
 0.74A 2zulA-1sxjE:
2.5		 2zulA-1sxjE:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.03A 2zxwA-1sxjE:
2.6
2zxwJ-1sxjE:
0.0		 2zxwA-1sxjE:
19.27
2zxwJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.02A 3abmA-1sxjE:
2.6
3abmJ-1sxjE:
undetectable		 3abmA-1sxjE:
19.27
3abmJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 VAL D  48
THR C 218
LEU C 219
TRP C  15
 None
 1.22A 3arrA-1sxjD:
undetectable		 3arrA-1sxjD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 0.98A 3asnA-1sxjE:
0.0
3asnJ-1sxjE:
undetectable		 3asnA-1sxjE:
19.27
3asnJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 0.98A 3asoA-1sxjE:
0.0
3asoJ-1sxjE:
0.0		 3asoA-1sxjE:
19.27
3asoJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLN B   8
CYH C 144
VAL C  37
PHE C  51
LEU C 146
 None
 1.32A 3b0wB-1sxjB:
undetectable		 3b0wB-1sxjB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER E 183
GLU D 141
ASP D  99
 None
MG  D 814 (-3.4A)
None
 0.74A 3dmhA-1sxjE:
2.7		 3dmhA-1sxjE:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 553
ASP A 583
ASP A 560
 None
 0.77A 3douA-1sxjA:
undetectable		 3douA-1sxjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET D  61
LEU D  58
PRO D 132
ILE D  92
MET D  88
 None
 1.38A 3g4lB-1sxjD:
undetectable		 3g4lB-1sxjD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 MET D  61
LEU D  58
PRO D 132
ILE D  92
MET D  88
 None
 1.37A 3g4lD-1sxjD:
undetectable		 3g4lD-1sxjD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 MET C 205
LEU C 169
ARG C 176
PRO C  21
SER C  61
 AGS  C 803 (-4.5A)
AGS  C 803 (-4.8A)
None
AGS  C 803 (-4.3A)
AGS  C 803 (-2.6A)
 1.44A 3hcnB-1sxjC:
0.2		 3hcnB-1sxjC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 TYR E 287
GLY A 624
SER A 622
ILE A 621
 None
 0.90A 3ihzB-1sxjE:
undetectable		 3ihzB-1sxjE:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 650
SER A 654
LEU B 286
 None
 0.54A 3n8xA-1sxjA:
undetectable		 3n8xA-1sxjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL E 116
VAL E  87
SER E  89
 None
 0.75A 3n8xB-1sxjE:
2.3		 3n8xB-1sxjE:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ASP C 276
ALA C 273
ILE C 310
GLY D  65
ILE C 275
 None
 1.04A 3nu4A-1sxjC:
undetectable		 3nu4A-1sxjC:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP D 330
GLU D 339
SER C 321
 None
 0.70A 3p2kA-1sxjD:
undetectable		 3p2kA-1sxjD:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASN D 171
ASP D 227
SER E 183
GLU D  29
GLU E 159
 AGS  D 804 (-3.1A)
None
None
AGS  D 804 (-3.9A)
None
 1.08A 3sg9A-1sxjD:
3.7		 3sg9A-1sxjD:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 7 ARG B 285
LEU B 286
ALA A 653
GLY A 561
ILE A 563
 None
 1.31A 3spkB-1sxjB:
undetectable		 3spkB-1sxjB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ARG B 285
LEU B 286
ALA A 653
GLY A 561
ILE A 563
 None
 1.32A 3spkA-1sxjB:
undetectable		 3spkA-1sxjB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 PRO B  17
SER C 159
VAL B 171
THR B  57
 AGS  B 802 (-4.4A)
None
None
AGS  B 802 (-3.8A)
 1.16A 3tneA-1sxjB:
undetectable		 3tneA-1sxjB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ARG B 285
THR A 573
GLY A 568
ASN A 571
ILE A 567
 None
 1.19A 3uayA-1sxjB:
undetectable		 3uayA-1sxjB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 SER A 540
ASP A 553
ASP A 560
 None
 0.66A 3uj7A-1sxjA:
undetectable		 3uj7A-1sxjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 GLU C 194
ARG C 176
VAL C 181
LEU C 182
 None
 1.02A 3uniA-1sxjC:
0.0		 3uniA-1sxjC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 209
MET B 202
ASP B 168
 None
AGS  B 802 (-4.7A)
None
 0.89A 3v5wA-1sxjB:
undetectable		 3v5wA-1sxjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ARG C 207
LEU C 197
LEU C 209
ASN C 210
ILE C 178
 None
 1.42A 3wdmA-1sxjC:
undetectable		 3wdmA-1sxjC:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ARG D 154
LEU D 180
ALA D 142
ILE D 176
 AGS  C 803 (-4.6A)
None
None
None
 0.93A 3wsjB-1sxjD:
undetectable		 3wsjB-1sxjD:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 345
TRP A 327
TRP A 323
 None
 1.42A 3zq8A-1sxjA:
undetectable
3zq8B-1sxjA:
undetectable		 3zq8A-1sxjA:
3.27
3zq8B-1sxjA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 354
ILE A 357
ARG A 477
GLY A 512
 None
AGS  A 801 (-4.4A)
None
None
 1.00A 4a3uB-1sxjA:
undetectable		 4a3uB-1sxjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 303
LEU E 300
ILE E 299
SER E 333
LEU E 279
 None
 1.08A 4dm8B-1sxjE:
undetectable		 4dm8B-1sxjE:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 PHE C 100
ALA C 101
THR C 141
LEU C 116
 None
 0.88A 4ejgB-1sxjC:
undetectable		 4ejgB-1sxjC:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU D 347
LEU D 343
LEU D 333
ILE D 271
SER E 175
 None
 1.13A 4f4dB-1sxjD:
undetectable		 4f4dB-1sxjD:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 VAL C  93
ALA C 126
THR C 123
GLU C 118
ALA C 119
 None
None
None
AGS  C 803 ( 4.9A)
None
 1.25A 4fiaA-1sxjC:
undetectable		 4fiaA-1sxjC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 VAL C  93
ALA C 126
THR C 123
GLU C 118
ALA C 119
 None
None
None
AGS  C 803 ( 4.9A)
None
 1.25A 4fiaA-1sxjC:
undetectable		 4fiaA-1sxjC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ALA B 310
SER B 311
VAL C 297
ARG C 296
 None
 1.03A 4ijiH-1sxjB:
undetectable		 4ijiH-1sxjB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 TYR D  83
THR D 164
VAL D 118
ILE D  92
 None
 1.00A 4jx1F-1sxjD:
0.0		 4jx1F-1sxjD:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU B 133
ARG A 383
PRO B 153
SER B 156
 None
None
AGS  A 801 ( 4.3A)
AGS  A 801 ( 4.4A)
 1.27A 4kmmB-1sxjB:
undetectable		 4kmmB-1sxjB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 586
ASN B 145
TYR B 163
ASP A 584
 None
AGS  B 802 (-3.1A)
None
None
 1.20A 4mdaA-1sxjA:
0.0		 4mdaA-1sxjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 SER A 540
ASP A 553
ASP A 560
 None
 0.73A 4mwzA-1sxjA:
undetectable		 4mwzA-1sxjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 LEU D 201
ARG D 202
SER D 205
LEU D 221
LEU D 235
 None
 1.20A 4or0B-1sxjD:
2.5		 4or0B-1sxjD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE E 298
LEU E 332
LEU E 342
ALA E 338
LEU E 289
 None
 1.11A 4p65E-1sxjE:
undetectable
4p65F-1sxjE:
undetectable
4p65J-1sxjE:
undetectable
4p65L-1sxjE:
undetectable		 4p65E-1sxjE:
5.82
4p65F-1sxjE:
8.70
4p65J-1sxjE:
8.70
4p65L-1sxjE:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.20A 4qvnV-1sxjA:
undetectable
4qvnb-1sxjA:
undetectable		 4qvnV-1sxjA:
16.25
4qvnb-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.20A 4qvnH-1sxjA:
undetectable
4qvnN-1sxjA:
undetectable		 4qvnH-1sxjA:
16.25
4qvnN-1sxjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN B 177
SER B  21
ASP B  22
 None
 0.96A 4qwpA-1sxjB:
2.1
4qwpB-1sxjB:
2.1		 4qwpA-1sxjB:
22.46
4qwpB-1sxjB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 317
ALA A 363
PHE A 475
 None
 0.88A 4w5nA-1sxjA:
undetectable		 4w5nA-1sxjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 THR B 295
THR B 269
HIS B 232
LEU B 256
 None
 1.28A 5axaC-1sxjB:
undetectable		 5axaC-1sxjB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.00A 5b1bA-1sxjE:
0.0
5b1bJ-1sxjE:
undetectable		 5b1bA-1sxjE:
19.27
5b1bJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 437
GLY A 436
ARG A 383
VAL A 426
 None
 1.39A 5d4nA-1sxjA:
0.0
5d4nB-1sxjA:
0.0		 5d4nA-1sxjA:
12.45
5d4nB-1sxjA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ASP D 227
LEU D 192
LEU D 221
LEU D 201
ALA D 197
 None
 0.95A 5dqfA-1sxjD:
4.6		 5dqfA-1sxjD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 8 ILE B 235
VAL B 236
ILE B 195
ILE B 194
PHE B 225
 None
 1.16A 5hi2A-1sxjB:
3.3		 5hi2A-1sxjB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 LEU E 113
LEU E  94
ARG E 134
 None
 0.58A 5hnzB-1sxjE:
undetectable		 5hnzB-1sxjE:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 323
LEU A 324
LEU A 453
ILE A 374
THR A 447
 None
 1.20A 5ienB-1sxjA:
0.0		 5ienB-1sxjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 142
ILE C 114
PHE C 143
 None
 0.71A 5kirA-1sxjC:
undetectable		 5kirA-1sxjC:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 589
TYR A 581
PHE A 587
SER B 147
 None
 1.21A 5l1fC-1sxjA:
undetectable		 5l1fC-1sxjA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 8 ILE C  63
ALA C  67
VAL C  41
PHE C  40
VAL C  37
 None
 1.41A 5l94A-1sxjC:
undetectable		 5l94A-1sxjC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 372
THR A 447
CYH A 444
CYH A 470
LEU A 451
 None
 1.31A 5lsuA-1sxjA:
undetectable		 5lsuA-1sxjA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE D 327
ILE C 318
ASN D 334
ALA D 298
SER E 175
 None
 1.25A 5mlmA-1sxjD:
undetectable		 5mlmA-1sxjD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE C 114
VAL C  93
MET C 122
LEU C 157
ILE C 134
 None
 1.29A 5mzpA-1sxjC:
1.8		 5mzpA-1sxjC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 396
VAL A 392
MET A 423
CYH A 444
 None
 1.22A 5te0A-1sxjA:
undetectable		 5te0A-1sxjA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 8 LEU C 299
VAL C 282
ILE C 327
GLY C 325
ILE C 275
 None
 1.03A 5vkqB-1sxjC:
2.2
5vkqC-1sxjC:
2.2		 5vkqB-1sxjC:
12.00
5vkqC-1sxjC:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU E 202
TYR E   8
LEU E 237
GLU E 238
 None
 1.31A 5weaA-1sxjE:
2.8		 5weaA-1sxjE:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 1.00A 5x1fA-1sxjE:
3.2
5x1fJ-1sxjE:
undetectable		 5x1fA-1sxjE:
19.27
5x1fJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 474
ILE A 422
HIS A 364
 None
 0.42A 5z12B-1sxjA:
undetectable		 5z12B-1sxjA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 TYR D 134
ARG D  91
THR D  79
LEU D  78
 None
 1.38A 5z86J-1sxjD:
0.0		 5z86J-1sxjD:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1sxj ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 ILE B  36
LEU B 161
HIS B  44
ALA B 159
 None
 1.03A 6ck2C-1sxjB:
undetectable
6ck2D-1sxjB:
undetectable		 6ck2C-1sxjB:
5.02
6ck2D-1sxjB:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ILE D 350
TYR D 308
LEU D 304
VAL D 275
 None
 1.19A 6f6jA-1sxjD:
undetectable		 6f6jA-1sxjD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ASP E  35
ARG E 166
GLN E  32
LYS D 240
 None
 1.48A 6g31A-1sxjE:
undetectable		 6g31A-1sxjE:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 316
ASP C 276
ASN C 202
 None
 0.76A 6gngB-1sxjC:
undetectable		 6gngB-1sxjC:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 671
SER A 674
ALA A 677
LYS A 678
 None
 0.67A 6hu9H-1sxjA:
undetectable
6hu9e-1sxjA:
undetectable		 6hu9H-1sxjA:
11.69
6hu9e-1sxjA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.23A 6hwdV-1sxjA:
undetectable
6hwdb-1sxjA:
undetectable		 6hwdV-1sxjA:
9.77
6hwdb-1sxjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 37 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR A 360
THR A 361
ALA A 363
ARG B 128
GLY A 356
 MG  A 811 ( 2.9A)
AGS  A 801 (-3.7A)
None
AGS  A 801 (-3.6A)
AGS  A 801 (-3.5A)
 1.23A 6hwdH-1sxjA:
undetectable
6hwdN-1sxjA:
undetectable		 6hwdH-1sxjA:
9.77
6hwdN-1sxjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ARG D 155
GLU C 118
ASP C 117
GLU C  81
 None
AGS  C 803 ( 4.9A)
MG  C 813 (-3.9A)
None
 1.33A 6mn5E-1sxjD:
0.0		 6mn5E-1sxjD:
12.69