SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU A  87
VAL A  78
PHE A  34
VAL A  60
ALA A  74
 None
 1.19A 1q23H-1sxlA:
undetectable
1q23I-1sxlA:
undetectable		 1q23H-1sxlA:
17.94
1q23I-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 10 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.40A 1q23K-1sxlA:
undetectable		 1q23K-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 11 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.36A 1q23L-1sxlA:
undetectable		 1q23L-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		4 / 6 LEU A  75
VAL A  78
ILE A  33
ILE A  40
 None
 0.73A 2piwA-1sxlA:
undetectable		 2piwA-1sxlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 10 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.46A 3u9fE-1sxlA:
undetectable		 3u9fE-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 12 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.45A 3u9fH-1sxlA:
undetectable
3u9fI-1sxlA:
undetectable		 3u9fH-1sxlA:
17.94
3u9fI-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 10 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.47A 3u9fI-1sxlA:
undetectable		 3u9fI-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 12 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.42A 3u9fJ-1sxlA:
undetectable
3u9fK-1sxlA:
undetectable		 3u9fJ-1sxlA:
17.94
3u9fK-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 10 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.42A 3u9fK-1sxlA:
undetectable		 3u9fK-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 11 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.49A 3u9fN-1sxlA:
undetectable
3u9fO-1sxlA:
undetectable		 3u9fN-1sxlA:
17.94
3u9fO-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 10 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.50A 3u9fR-1sxlA:
undetectable		 3u9fR-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 12 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.43A 3u9fP-1sxlA:
undetectable
3u9fS-1sxlA:
undetectable		 3u9fP-1sxlA:
17.94
3u9fS-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		3 / 3 LYS A  64
LEU A  16
ILE A  40
 None
 0.56A 5kc0A-1sxlA:
undetectable		 5kc0A-1sxlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		3 / 3 LYS A  64
LEU A  16
ILE A  40
 None
 0.69A 5kc4A-1sxlA:
undetectable		 5kc4A-1sxlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1sxl SEX-LETHAL PROTEIN
PROTEIN
(Drosophila
melanogaster) 		5 / 7 GLY A   7
SER A  73
LEU A  16
THR A  14
ALA A  68
 None
 1.38A 5o96C-1sxlA:
undetectable		 5o96C-1sxlA:
22.41