SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 5 LEU A 174
GLY A 101
ALA A 146
ILE A 148
 None
SO4  A 401 (-3.4A)
None
None
 0.84A 2aohB-1sxrA:
undetectable		 2aohB-1sxrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 7 LEU A  58
GLY A 108
ILE A 109
ILE A  74
 None
 0.78A 2aojB-1sxrA:
undetectable		 2aojB-1sxrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		5 / 10 LEU A 174
VAL A  39
GLY A 101
ALA A 146
ILE A 148
 None
None
SO4  A 401 (-3.4A)
None
None
 0.96A 3ekpB-1sxrA:
undetectable		 3ekpB-1sxrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		5 / 8 ILE A  85
LEU A  51
ILE A  57
LYS A  23
GLY A  22
 None
 1.45A 4hb8A-1sxrA:
undetectable		 4hb8A-1sxrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 7 TYR A  76
ILE A  74
GLY A  91
TYR A  30
 EDO  A 404 (-4.4A)
None
None
None
 0.75A 4iqqA-1sxrA:
undetectable		 4iqqA-1sxrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 6 ALA A 127
LEU A 125
SER A 121
VAL A  86
 None
 1.22A 5a6iA-1sxrA:
undetectable		 5a6iA-1sxrA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 7 ILE A  85
GLY A  84
LEU A 141
ASP A 130
 None
 0.85A 5hieB-1sxrA:
undetectable		 5hieB-1sxrA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		5 / 12 ASP A 122
LEU A 132
ALA A 128
PRO A 120
LEU A 163
 None
 1.23A 5nd4B-1sxrA:
undetectable		 5nd4B-1sxrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 8 GLY A 150
GLN A  31
VAL A  39
TYR A  76
 None
None
None
EDO  A 404 (-4.4A)
 0.91A 5vlmA-1sxrA:
undetectable		 5vlmA-1sxrA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		4 / 6 ALA A  55
GLN A  59
TRP A  20
GLN A  62
 None
 1.31A 5y9aA-1sxrA:
undetectable		 5y9aA-1sxrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA
(Drosophila
melanogaster) 		5 / 12 ASP A 122
LEU A 132
ALA A 128
PRO A 120
LEU A 163
 None
 1.07A 6b0iB-1sxrA:
undetectable		 6b0iB-1sxrA:
16.95