SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1sy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 GLU A 141
ARG A 186
ILE H  51
ALA H  79
THR H  58
 None
 1.32A 1aj6A-1sy6A:
undetectable		 1aj6A-1sy6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens) 		5 / 10 PHE A 172
VAL A 130
VAL A 123
ASN A 147
LEU A 197
 None
 1.24A 1fe2A-1sy6A:
0.0		 1fe2A-1sy6A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLU A 155
GLY A 153
SER H  54
THR H  30
 None
 1.32A 1icrA-1sy6A:
undetectable
1icrB-1sy6A:
undetectable		 1icrA-1sy6A:
23.93
1icrB-1sy6A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 SER H  54
THR H  30
GLU A 155
GLY A 153
 None
 1.33A 1icvC-1sy6H:
undetectable
1icvD-1sy6H:
undetectable		 1icvC-1sy6H:
20.49
1icvD-1sy6H:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLU A 155
GLY A 153
SER H  54
THR H  30
 None
 1.30A 1icvC-1sy6A:
undetectable
1icvD-1sy6A:
undetectable		 1icvC-1sy6A:
23.93
1icvD-1sy6A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
OKT3 FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLU A 155
GLY A 153
SER H  54
THR H  30
 None
 1.28A 1kqbA-1sy6A:
undetectable
1kqbB-1sy6A:
undetectable		 1kqbA-1sy6A:
25.83
1kqbB-1sy6A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens) 		5 / 12 LEU A 167
LEU A 132
LEU A 197
ILE A 160
VAL A  11
 None
 1.02A 2pnjA-1sy6A:
undetectable		 2pnjA-1sy6A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 LEU H   4
ALA H  79
SER H  77
THR H  72
 None
 0.98A 3d2tA-1sy6H:
undetectable		 3d2tA-1sy6H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
OKT3 FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 ALA H  24
ARG A 186
ILE H  48
TYR H  60
LEU H  70
 None
 0.96A 3mb5A-1sy6H:
undetectable		 3mb5A-1sy6H:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR H  27
ASP H 107
ASP H 102
 None
 0.73A 3ou7B-1sy6H:
undetectable		 3ou7B-1sy6H:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H   4
ALA H  79
SER H  77
THR H  72
 None
 0.96A 4i89A-1sy6H:
3.8		 4i89A-1sy6H:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.38A 4m7kH-1sy6H:
27.7		 4m7kH-1sy6H:
67.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 ILE A 151
ARG H  31
ASP H 102
VAL A 182
 None
 1.22A 4nkxC-1sy6A:
undetectable		 4nkxC-1sy6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens) 		3 / 3 LEU A 199
LEU A  22
ASN A  55
 None
 0.77A 4otwA-1sy6A:
undetectable		 4otwA-1sy6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H   4
ALA H  79
SER H  77
THR H  72
 None
 0.95A 5bojA-1sy6H:
3.7		 5bojA-1sy6H:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 6 LEU H   4
ALA H  79
SER H  77
THR H  72
 None
 0.98A 5l4iA-1sy6H:
undetectable		 5l4iA-1sy6H:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1sy6 OKT3 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER H 118
ALA H 120
PHE H 152
LEU H 176
 None
 0.25A 5mthA-1sy6H:
19.0		 5mthA-1sy6H:
78.64