SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1szb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_1 (DIPEPTIDYL PEPTIDASE IV)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	5 / 12	GLU A 52 SER A 54 PHE A 61 TYR A 24 ASN A 108	GLU A 52 (-0.6A) SER A 54 ( 0.0A) PHE A 61 ( 1.3A) TYR A 24 ( 1.3A) ASN A 108 (-0.6A)	1.05A	1x70A-1szbA: undetectable	1x70A-1szbA: 11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_A_ACTA5_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	3 / 3	LYS A 110 SER A 79 GLN A 77	LYS A 110 ( 0.0A) SER A 79 ( 0.0A) GLN A 77 ( 0.6A)	1.12A	3si7A-1szbA: undetectable	3si7A-1szbA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJG_C_NCTC501_1 (CYTOCHROME P450 2A13)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	4 / 7	PHE A 49 PHE A 46 ALA A 72 LEU A 44	PHE A 49 ( 1.3A) PHE A 46 ( 1.3A) ALA A 72 ( 0.0A) LEU A 44 ( 0.6A)	0.62A	4ejgC-1szbA: undetectable	4ejgC-1szbA: 16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJG_C_NCTC501_1 (CYTOCHROME P450 2A13)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	4 / 7	PHE A 49 PHE A 46 LEU A 98 LEU A 44	PHE A 49 ( 1.3A) PHE A 46 ( 1.3A) LEU A 98 ( 0.6A) LEU A 44 ( 0.6A)	0.87A	4ejgC-1szbA: undetectable	4ejgC-1szbA: 16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJG_C_NCTC501_1 (CYTOCHROME P450 2A13)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	4 / 7	PHE A 115 PHE A 49 PHE A 46 LEU A 44	PHE A 115 ( 1.3A) PHE A 49 ( 1.3A) PHE A 46 ( 1.3A) LEU A 44 ( 0.6A)	0.80A	4ejgC-1szbA: undetectable	4ejgC-1szbA: 16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_B_CVIB603_0 (ACETYLCHOLINESTERASE)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	4 / 7	TYR A 59 GLN A 77 ASP A 50 TYR A 106	TYR A 59 ( 1.3A) GLN A 77 ( 0.6A) ASP A 50 ( 0.6A) TYR A 106 ( 1.3A)	1.37A	5ov9B-1szbA: undetectable	5ov9B-1szbA: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_B_8NUB3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	1szb	MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA) (Homo sapiens)	5 / 12	TYR A 92 THR A 82 LEU A 71 PHE A 49 LEU A 44	TYR A 92 ( 1.3A) THR A 82 ( 0.8A) LEU A 71 ( 0.6A) PHE A 49 ( 1.3A) LEU A 44 ( 0.6A)	1.31A	6a93B-1szbA: undetectable	6a93B-1szbA: 19.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1X70_A_715A801_1","DIPEPTIDYL PEPTIDASE IV","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",5,"GLU A  52;SER A  54;PHE A  61;TYR A  24;ASN A 108","GLU A  52 (-0.6A);SER A  54 ( 0.0A);PHE A  61 ( 1.3A);TYR A  24 ( 1.3A);ASN A 108 (-0.6A)","1.05A","1x70A-1szbA:undetectable","1x70A-1szbA:11.93"],["3SI7_A_ACTA5_0","CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",3,"LYS A 110;SER A  79;GLN A  77","LYS A 110 ( 0.0A);SER A  79 ( 0.0A);GLN A  77 ( 0.6A)","1.12A","3si7A-1szbA:undetectable","3si7A-1szbA:19.16"],["4EJG_C_NCTC501_1","CYTOCHROME P450 2A13","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",4,"PHE A  49;PHE A  46;ALA A  72;LEU A  44","PHE A  49 ( 1.3A);PHE A  46 ( 1.3A);ALA A  72 ( 0.0A);LEU A  44 ( 0.6A)","0.62A","4ejgC-1szbA:undetectable","4ejgC-1szbA:16.95"],["4EJG_C_NCTC501_1","CYTOCHROME P450 2A13","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",4,"PHE A  49;PHE A  46;LEU A  98;LEU A  44","PHE A  49 ( 1.3A);PHE A  46 ( 1.3A);LEU A  98 ( 0.6A);LEU A  44 ( 0.6A)","0.87A","4ejgC-1szbA:undetectable","4ejgC-1szbA:16.95"],["4EJG_C_NCTC501_1","CYTOCHROME P450 2A13","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",4,"PHE A 115;PHE A  49;PHE A  46;LEU A  44","PHE A 115 ( 1.3A);PHE A  49 ( 1.3A);PHE A  46 ( 1.3A);LEU A  44 ( 0.6A)","0.80A","4ejgC-1szbA:undetectable","4ejgC-1szbA:16.95"],["5OV9_B_CVIB603_0","ACETYLCHOLINESTERASE","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",4,"TYR A  59;GLN A  77;ASP A  50;TYR A 106","TYR A  59 ( 1.3A);GLN A  77 ( 0.6A);ASP A  50 ( 0.6A);TYR A 106 ( 1.3A)","1.37A","5ov9B-1szbA:undetectable","5ov9B-1szbA:17.54"],["6A93_B_8NUB3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","1szb","MANNOSE BINDING LECTIN-ASSOCIATED SERINE PROTEASE-2 RELATED PROTEIN, MAP19 (19KDA)","Homo sapiens",5,"TYR A  92;THR A  82;LEU A  71;PHE A  49;LEU A  44","TYR A  92 ( 1.3A);THR A  82 ( 0.8A);LEU A  71 ( 0.6A);PHE A  49 ( 1.3A);LEU A  44 ( 0.6A)","1.31A","6a93B-1szbA:undetectable","6a93B-1szbA:19.18"]]