SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1szi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		4 / 8 ALA A 269
LEU A 273
LEU A 405
ALA A 401
 None
 0.81A 1e7cA-1sziA:
2.1		 1e7cA-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		3 / 3 THR A 272
LEU A 276
VAL A 279
 None
 0.61A 1mz9E-1sziA:
2.1		 1mz9E-1sziA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		5 / 10 ALA A 265
ALA A 269
LEU A 273
LEU A 405
ALA A 401
 None
 1.12A 2bxeA-1sziA:
2.4		 2bxeA-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		5 / 10 ALA A 265
ALA A 269
LEU A 273
LEU A 405
LEU A 262
 None
 1.24A 2bxeA-1sziA:
2.4		 2bxeA-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		6 / 10 ALA A 265
ALA A 269
LEU A 273
LEU A 405
ALA A 401
LEU A 262
 None
 1.39A 2bxgB-1sziA:
2.5		 2bxgB-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		4 / 7 LEU A 208
PRO A 417
VAL A 422
MET A 419
 None
 1.36A 2hrcA-1sziA:
undetectable		 2hrcA-1sziA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		3 / 3 PRO A 417
GLU A 410
TYR A 411
 None
 0.52A 2zmbA-1sziA:
undetectable		 2zmbA-1sziA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		4 / 8 THR A 338
LEU A 276
LEU A 273
ILE A 398
 None
 0.95A 3nbqB-1sziA:
undetectable		 3nbqB-1sziA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		5 / 12 ILE A 218
VAL A 241
LEU A 215
ALA A 254
LEU A 250
 None
 1.02A 4m11B-1sziA:
undetectable		 4m11B-1sziA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		5 / 12 ILE A 218
VAL A 241
LEU A 215
ALA A 254
LEU A 250
 None
 1.08A 4o1zB-1sziA:
undetectable		 4o1zB-1sziA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		3 / 3 VAL A 390
PHE A 334
ARG A 335
 None
 0.89A 4xr4B-1sziA:
undetectable		 4xr4B-1sziA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1
(Mus
musculus) 		5 / 12 THR A 338
THR A 272
GLN A 274
CYH A 345
ALA A 401
 None
 1.38A 5l5zH-1sziA:
undetectable
5l5zI-1sziA:
undetectable		 5l5zH-1sziA:
23.19
5l5zI-1sziA:
22.59