SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1szn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 THR A 267
LEU A 266
VAL A 261
LEU A 259
 None
 0.92A 1fbmD-1sznA:
undetectable		 1fbmD-1sznA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.16A 1mj2B-1sznA:
undetectable		 1mj2B-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.23A 1mj2D-1sznA:
undetectable		 1mj2D-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.19A 1mjoB-1sznA:
undetectable		 1mjoB-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.18A 1mjoA-1sznA:
undetectable		 1mjoA-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 4 HIS A 196
ALA A 122
PHE A 121
GLY A 125
 None
 1.18A 1mjoD-1sznA:
undetectable		 1mjoD-1sznA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 5 VAL A  86
LEU A  89
ILE A  38
ALA A  34
 None
 0.86A 3n8yB-1sznA:
undetectable		 3n8yB-1sznA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.07A 3sudA-1sznA:
undetectable		 3sudA-1sznA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.00A 3sudD-1sznA:
undetectable		 3sudD-1sznA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.02A 3sueA-1sznA:
undetectable		 3sueA-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.08A 3sueB-1sznA:
undetectable		 3sueB-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.05A 3sueC-1sznA:
undetectable		 3sueC-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 11 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.05A 3sufC-1sznA:
undetectable		 3sufC-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 ASN A 133
TRP A 205
ASP A 142
 GOL  A 901 (-2.9A)
None
GOL  A 901 (-3.7A)
 1.12A 4a7tA-1sznA:
undetectable
4a7tF-1sznA:
undetectable		 4a7tA-1sznA:
18.47
4a7tF-1sznA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 8 TRP A 221
HIS A 253
GLN A 318
GLY A 317
 None
None
None
NAG  A 701 ( 4.3A)
 0.97A 4f93B-1sznA:
undetectable		 4f93B-1sznA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 PRO A 229
ASN A  20
HIS A  23
 None
 0.96A 4ma3H-1sznA:
0.0
4ma3L-1sznA:
0.0		 4ma3H-1sznA:
21.28
4ma3L-1sznA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 GLY A 317
GLY A 344
SER A 314
ASN A 311
PHE A 310
 NAG  A 701 ( 4.3A)
None
BMA  A 705 ( 4.6A)
None
None
 1.26A 4obwC-1sznA:
undetectable		 4obwC-1sznA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 LEU A 358
LEU A 238
ASN A 334
 None
None
NAG  A 800 (-1.8A)
 0.59A 4otwA-1sznA:
undetectable		 4otwA-1sznA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 ASP A 132
TYR A  96
TRP A 205
 GOL  A 900 (-4.3A)
GOL  A 900 (-4.6A)
None
 1.04A 4p7nA-1sznA:
11.2		 4p7nA-1sznA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 GLN A 207
SER A 178
ASP A 142
 None
None
GOL  A 901 (-3.7A)
 0.93A 4qwpA-1sznA:
undetectable
4qwpB-1sznA:
undetectable		 4qwpA-1sznA:
19.90
4qwpB-1sznA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 SER A 201
TYR A 128
ASP A 257
 None
 0.74A 4rp8C-1sznA:
0.0		 4rp8C-1sznA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 ALA A 280
LEU A 307
THR A 405
GLY A 344
PRO A 345
 None
 1.11A 4ypmA-1sznA:
undetectable		 4ypmA-1sznA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 8 ILE A 227
ILE A  95
ILE A  68
ILE A  53
ASP A  55
 None
None
None
None
GOL  A 900 (-3.7A)
 1.09A 5hi2A-1sznA:
undetectable		 5hi2A-1sznA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 301
LEU A 259
ILE A  38
LEU A 291
LEU A  14
 None
 1.10A 5toaB-1sznA:
undetectable		 5toaB-1sznA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		5 / 12 LEU A 301
LEU A 294
ILE A  38
LEU A 291
LEU A  14
 None
 1.24A 5toaB-1sznA:
undetectable		 5toaB-1sznA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		4 / 6 LEU A 353
VAL A 355
THR A 357
LEU A 259
 None
 0.80A 5tudD-1sznA:
undetectable		 5tudD-1sznA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1szn ALPHA-GALACTOSIDASE
(Trichoderma
reesei) 		3 / 3 SER A  29
LYS A  30
SER A  33
 None
 0.74A 6az3P-1sznA:
0.0		 6az3P-1sznA:
11.38