SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1szp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 286
LEU A 303
SER A 281
GLU A 182
 None
 0.93A 1i7zA-1szpA:
undetectable		 1i7zA-1szpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 168
ILE A 158
GLY A 211
GLY A 210
ILE A 208
 None
 1.28A 1sguA-1szpA:
undetectable		 1sguA-1szpA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 113
ASP A 117
ILE A 121
GLY A 103
LEU A  86
 None
 1.00A 2o4nA-1szpA:
undetectable		 2o4nA-1szpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 184
GLY A 347
ALA A 351
LEU A 303
 None
 0.86A 3bgdA-1szpA:
2.5		 3bgdA-1szpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 218
ARG A 312
ILE A 277
THR A 220
 None
 1.28A 3ia4C-1szpA:
undetectable		 3ia4C-1szpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 9 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.07A 4c9kA-1szpA:
undetectable		 4c9kA-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 9 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.07A 4c9kB-1szpA:
undetectable		 4c9kB-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 8 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.05A 4c9nA-1szpA:
undetectable		 4c9nA-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.05A 4c9oA-1szpA:
undetectable		 4c9oA-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
 None
 1.05A 4c9oB-1szpA:
undetectable		 4c9oB-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 1.01A 4eyzA-1szpA:
undetectable		 4eyzA-1szpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  96
HIS A 105
ILE A  83
ALA A 266
 None
 1.00A 4eyzB-1szpA:
undetectable		 4eyzB-1szpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 394
ASN A 166
CYH A 383
ASP A 168
 None
 1.21A 4feuF-1szpA:
undetectable		 4feuF-1szpA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 352
VAL A 282
LEU A 303
 None
 0.76A 4m2vA-1szpA:
undetectable		 4m2vA-1szpA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 7 THR A 197
LEU A 198
LEU A 194
THR A 201
 None
 0.92A 4z90A-1szpA:
undetectable
4z90B-1szpA:
undetectable
4z90C-1szpA:
undetectable
4z90D-1szpA:
undetectable
4z90E-1szpA:
undetectable		 4z90A-1szpA:
21.21
4z90B-1szpA:
21.21
4z90C-1szpA:
21.21
4z90D-1szpA:
21.21
4z90E-1szpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 SER A 179
GLY A 174
ALA A 320
THR A 181
 None
 0.94A 5eevL-1szpA:
undetectable
5eevV-1szpA:
undetectable		 5eevL-1szpA:
13.00
5eevV-1szpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 SER A 179
GLY A 174
ALA A 320
THR A 181
 None
 0.95A 5eewL-1szpA:
undetectable
5eewV-1szpA:
undetectable		 5eewL-1szpA:
13.00
5eewV-1szpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 8 SER A 179
GLY A 174
ALA A 320
THR A 181
 None
 0.95A 5ef3L-1szpA:
undetectable
5ef3V-1szpA:
undetectable		 5ef3L-1szpA:
13.00
5ef3V-1szpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 194
LEU A 198
VAL A 321
LEU A 171
CYH A 370
 None
 1.20A 5uc1A-1szpA:
undetectable		 5uc1A-1szpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 MET A 269
MET A 268
ALA A 264
ILE A 277
PHE A 306
 None
 1.22A 5vlmB-1szpA:
undetectable		 5vlmB-1szpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		5 / 12 MET A 269
MET A 268
ALA A 264
LEU A 313
ILE A 277
 None
 1.24A 5vlmB-1szpA:
undetectable		 5vlmB-1szpA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 368
ARG A 228
ARG A 188
 None
 0.87A 6bplA-1szpA:
7.4
6bplB-1szpA:
7.9		 6bplA-1szpA:
14.74
6bplB-1szpA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1szp DNA REPAIR PROTEIN
RAD51
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 323
ILE A 218
GLY A 103
ALA A 309
 None
 0.82A 6hd6B-1szpA:
undetectable		 6hd6B-1szpA:
15.19