SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1szs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 263
ALA A 202
LEU A 148
GLU A 116
VAL A 279
 None
 1.17A 1ictA-1szsA:
0.0
1ictC-1szsA:
0.0		 1ictA-1szsA:
14.58
1ictC-1szsA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 HIS A 365
ASP A 364
ASP A 362
PRO A 368
 None
 0.83A 1ilqA-1szsA:
0.0
1ilqC-1szsA:
undetectable		 1ilqA-1szsA:
9.62
1ilqC-1szsA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 GLU A  67
LYS A  61
VAL A  63
 None
 0.93A 1l2iA-1szsA:
undetectable		 1l2iA-1szsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 397
LEU A 359
ALA A 337
LEU A 414
PHE A 421
 None
 1.26A 1tbfA-1szsA:
undetectable		 1tbfA-1szsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 1.00A 2q6hA-1szsA:
0.0		 2q6hA-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 1.00A 2q72A-1szsA:
undetectable		 2q72A-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 0.98A 2qb4A-1szsA:
0.0		 2qb4A-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 1.01A 2qeiA-1szsA:
undetectable		 2qeiA-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 SER A 217
ILE A 205
ALA A 238
THR A 264
ARG A 247
 None
 1.30A 2v0mD-1szsA:
0.0		 2v0mD-1szsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 8 LEU A  58
ALA A  30
GLY A  56
LEU A  53
GLY A  49
 None
None
None
None
EDO  A1223 (-3.5A)
 1.38A 2yfxA-1szsA:
undetectable		 2yfxA-1szsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 225
ILE A 234
ALA A 202
THR A 131
ALA A 133
 None
 1.09A 3mdtA-1szsA:
undetectable		 3mdtA-1szsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 PHE A 191
ILE A 187
CYH A 229
HIS A 232
 None
 1.14A 3r0lD-1szsA:
undetectable		 3r0lD-1szsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A 115
SER A 112
TYR A 138
GLY A 140
 None
PLP  A1261 ( 2.6A)
PMP  A1271 (-4.2A)
PLP  A1261 ( 3.9A)
 1.13A 3tj7C-1szsA:
0.0
3tj7D-1szsA:
0.0		 3tj7C-1szsA:
20.66
3tj7D-1szsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 403
GLY A  56
HIS A  57
ALA A 307
ASN A  54
 None
None
EDO  A1223 (-3.9A)
None
None
 1.04A 3tm4A-1szsA:
undetectable		 3tm4A-1szsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 403
GLY A  56
HIS A  57
ALA A 307
ASN A  54
 None
None
EDO  A1223 (-3.9A)
None
None
 1.01A 3tm4B-1szsA:
3.2		 3tm4B-1szsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 377
LEU A 372
ALA A 356
ILE A 417
VAL A 348
 None
 1.15A 3w67C-1szsA:
undetectable		 3w67C-1szsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA A 245
ILE A 270
GLY A 272
VAL A  52
ASN A  54
 None
 1.28A 4a3uA-1szsA:
undetectable		 4a3uA-1szsA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 GLU A 206
TYR A 215
ARG A 349
GLY A 391
 PMP  A1271 ( 3.9A)
None
None
None
 1.07A 4fgzA-1szsA:
undetectable		 4fgzA-1szsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 LEU A 225
ILE A 234
ALA A 202
THR A 131
ALA A 133
 None
 1.09A 4j14A-1szsA:
undetectable		 4j14A-1szsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A 384
ASP A  37
ASP A  45
ASP A 382
 None
None
EDO  A1223 (-2.8A)
None
 0.98A 4uckB-1szsA:
2.5		 4uckB-1szsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A 350
GLY A 249
LEU A 321
GLY A 210
VAL A 208
 None
None
None
EDO  A1232 ( 4.8A)
None
 0.95A 5i73A-1szsA:
undetectable		 5i73A-1szsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 270
GLU A  84
ALA A  68
ALA A  65
VAL A  62
 None
 1.32A 5igpA-1szsA:
undetectable		 5igpA-1szsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 297
HIS A  75
ASN A 301
 SO4  A1213 ( 4.7A)
None
None
 0.69A 5n4tA-1szsA:
2.7		 5n4tA-1szsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLN A 242
ALA A  51
GLY A  49
LEU A 388
CYH A  33
 EDO  A1232 (-3.3A)
None
EDO  A1223 (-3.5A)
None
None
 1.42A 5vlmF-1szsA:
0.0		 5vlmF-1szsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 241
GLY A 244
ALA A 253
GLU A 116
VAL A 204
 PMP  A1271 ( 4.1A)
None
None
None
None
 1.12A 6bqgA-1szsA:
undetectable		 6bqgA-1szsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 276
ASN A  94
LEU A 312
 None
 0.67A 6exiA-1szsA:
undetectable		 6exiA-1szsA:
11.74