SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 8 SER A  47
ILE A  50
LEU A  51
LEU A  79
LEU A  85
 None
 1.32A 1eupA-1t0aA:
0.0		 1eupA-1t0aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		3 / 3 GLN A 159
TYR A  83
ARG A  80
 None
 0.87A 1gtbA-1t0aA:
0.0		 1gtbA-1t0aA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ILE A 100
ASP A  40
LEU A  43
ILE A 129
LEU A  96
 None
 1.31A 1rh3A-1t0aA:
undetectable		 1rh3A-1t0aA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 5 ALA A 119
GLN A 116
ILE A 129
ARG A 115
 None
 1.38A 2z0aA-1t0aA:
undetectable		 2z0aA-1t0aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 9 GLY A  52
ALA A  53
ILE A   5
ILE A  46
LEU A 156
 None
 1.00A 3ogpA-1t0aA:
undetectable		 3ogpA-1t0aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 11 ARG A  76
LEU A  43
ASP A  97
VAL A 126
ILE A  46
 None
 1.12A 3oxxB-1t0aA:
undetectable		 3oxxB-1t0aA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ALA A 120
ASP A  40
ILE A  21
ASP A  74
ASP A 121
 None
 1.41A 3wemA-1t0aA:
undetectable		 3wemA-1t0aA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ALA A 120
ASP A  40
ILE A  21
ASP A  74
ASP A 121
 None
 1.39A 3wenA-1t0aA:
undetectable		 3wenA-1t0aA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ALA A 120
ASP A  40
ILE A  21
ASP A  74
ASP A 121
 None
 1.40A 3weoA-1t0aA:
undetectable		 3weoA-1t0aA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ILE A 129
VAL A 131
LEU A 118
VAL A 150
ALA A 152
 None
 1.20A 4m11C-1t0aA:
undetectable		 4m11C-1t0aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		5 / 12 ILE A 129
VAL A 131
LEU A 118
VAL A 150
ALA A 152
 None
 1.17A 4m11D-1t0aA:
undetectable		 4m11D-1t0aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 8 GLY A  72
GLY A  39
ILE A  21
LEU A  43
 None
 0.84A 4mwzB-1t0aA:
0.0		 4mwzB-1t0aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 5 HIS A  44
ALA A  73
SER A  37
GLY A  39
 ZN  A 661 (-3.1A)
None
None
None
 1.12A 5yodB-1t0aA:
undetectable		 5yodB-1t0aA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 5 HIS A  44
ALA A  73
SER A  37
GLY A  39
 ZN  A 661 (-3.1A)
None
None
None
 1.16A 5yodD-1t0aA:
undetectable		 5yodD-1t0aA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 4 HIS A  12
LEU A  78
TYR A  70
GLY A  60
 ZN  A 661 (-3.2A)
None
None
None
 1.39A 6n91A-1t0aA:
undetectable		 6n91A-1t0aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 1t0a 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Shewanella
oneidensis) 		4 / 4 HIS A  12
LEU A  78
TYR A  70
GLY A  60
 ZN  A 661 (-3.2A)
None
None
None
 1.41A 6n91B-1t0aA:
undetectable		 6n91B-1t0aA:
20.75