SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 131
VAL A 178
TRP A 172
 None
 1.47A 1gmkC-1t0bA:
undetectable
1gmkD-1t0bA:
undetectable		 1gmkC-1t0bA:
6.67
1gmkD-1t0bA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  19
THR A 201
GLU A 153
 None
None
ZN  A3001 (-3.3A)
 0.80A 1pj7A-1t0bA:
2.1		 1pj7A-1t0bA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 ALA A 221
VAL A 218
ALA A 217
HIS A 137
 None
 1.18A 1q23A-1t0bA:
undetectable		 1q23A-1t0bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 4 ALA A 221
VAL A 218
ALA A 217
HIS A 137
 None
 1.14A 1q23K-1t0bA:
undetectable		 1q23K-1t0bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
PHE A 179
VAL A 213
VAL A 210
 None
 1.14A 1x70A-1t0bA:
2.0		 1x70A-1t0bA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
PHE A 179
VAL A 213
VAL A 210
 None
 1.11A 2rguA-1t0bA:
2.6		 2rguA-1t0bA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
PHE A 179
VAL A 213
VAL A 210
 None
 1.11A 3bjmB-1t0bA:
undetectable		 3bjmB-1t0bA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
TYR A 194
VAL A 213
VAL A 210
 None
 1.22A 3g0bA-1t0bA:
undetectable		 3g0bA-1t0bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
TYR A 194
VAL A 213
VAL A 210
 None
 1.20A 3g0bB-1t0bA:
2.6		 3g0bB-1t0bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
TYR A 194
VAL A 213
VAL A 210
 None
 1.20A 3g0bC-1t0bA:
undetectable		 3g0bC-1t0bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
TYR A 194
VAL A 213
VAL A 210
 None
 1.21A 3g0bD-1t0bA:
2.6		 3g0bD-1t0bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A  87
VAL A  79
ILE A 192
VAL A  99
 None
 0.88A 3hjoB-1t0bA:
undetectable		 3hjoB-1t0bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 155
TYR A 194
GLU A 152
 None
 0.69A 3pfgA-1t0bA:
undetectable		 3pfgA-1t0bA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 127
GLU A 148
TRP A 131
 None
 1.32A 3v4tH-1t0bA:
0.0		 3v4tH-1t0bA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 194
ARG A 196
SER A 181
 None
 1.08A 4dr2I-1t0bA:
undetectable
4dr2J-1t0bA:
undetectable		 4dr2I-1t0bA:
18.55
4dr2J-1t0bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 152
GLU A 128
PHE A 179
VAL A 213
VAL A 210
 None
 1.08A 4ffwB-1t0bA:
undetectable		 4ffwB-1t0bA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 194
ARG A 196
SER A 181
 None
 1.06A 4khpI-1t0bA:
undetectable
4khpJ-1t0bA:
undetectable		 4khpI-1t0bA:
19.21
4khpJ-1t0bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 218
ILE A  98
LEU A  97
ILE A 214
GLY A 103
 None
 1.09A 4kukA-1t0bA:
undetectable		 4kukA-1t0bA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 194
ARG A 196
SER A 181
 None
 1.17A 4lf7I-1t0bA:
undetectable
4lf7J-1t0bA:
undetectable		 4lf7I-1t0bA:
18.55
4lf7J-1t0bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 194
ARG A 196
SER A 181
 None
 1.17A 4lf8I-1t0bA:
undetectable
4lf8J-1t0bA:
undetectable		 4lf8I-1t0bA:
18.55
4lf8J-1t0bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 169
ILE A 139
ASP A 165
 None
 0.76A 5cswA-1t0bA:
undetectable		 5cswA-1t0bA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A 169
ILE A 139
ASP A 165
 None
 0.73A 5cswB-1t0bA:
undetectable		 5cswB-1t0bA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A  48
LEU A  57
PHE A 185
ILE A 161
GLY A 182
 None
 1.19A 5eshA-1t0bA:
undetectable		 5eshA-1t0bA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A  19
HIS A  15
ILE A  25
TYR A 202
 None
 1.09A 5ih0A-1t0bA:
undetectable		 5ih0A-1t0bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 155
GLU A 152
GLY A 198
SER A 102
 None
None
None
ZN  A3001 ( 4.0A)
 1.27A 5jhdJ-1t0bA:
0.0		 5jhdJ-1t0bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 210
ALA A 217
PHE A 169
GLU A 148
VAL A 132
 None
 1.13A 6bqgA-1t0bA:
undetectable		 6bqgA-1t0bA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1t0b THUA-LIKE PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A  69
HIS A  31
TYR A 205
GLU A  12
 None
 1.32A 6gneB-1t0bA:
5.3		 6gneB-1t0bA:
19.71