SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		4 / 8 GLU B 298
LEU B 334
ALA B 320
VAL B 230
 None
 0.74A 1a29A-1t0hB:
undetectable		 1a29A-1t0hB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		4 / 8 THR B 322
ILE B 338
LEU B 272
LEU B 334
 None
 1.01A 4r38B-1t0hB:
undetectable		 4r38B-1t0hB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 5 PHE A  62
PRO B 224
VAL B 222
ALA A  63
 None
 1.30A 4w5oA-1t0hA:
undetectable		 4w5oA-1t0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 5 PHE A  62
PRO B 224
VAL B 222
ALA A  63
 None
 1.31A 4z4dA-1t0hA:
undetectable		 4z4dA-1t0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 5 PHE A  62
PRO B 224
VAL B 222
ALA A  63
 None
 1.31A 4z4eA-1t0hA:
undetectable		 4z4eA-1t0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		5 / 12 PRO B 326
LEU B 329
GLY B 233
LEU B 387
ASN B 324
 None
 1.43A 5emlA-1t0hB:
undetectable		 5emlA-1t0hB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		3 / 3 ASP A  76
SER A  86
TYR A  70
 None
 0.92A 5glmA-1t0hA:
undetectable		 5glmA-1t0hA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		5 / 11 ILE A  85
ASP A  91
THR A  66
VAL A  64
VAL A  95
 None
 1.17A 5jkwA-1t0hA:
undetectable		 5jkwA-1t0hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		3 / 3 LEU B 403
ALA B 400
LEU B 315
 None
 0.54A 5uunB-1t0hB:
undetectable		 5uunB-1t0hB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A
(Rattus
norvegicus) 		4 / 5 PHE B 250
PHE B 252
LEU B 249
LEU B 315
 None
 1.37A 5veuH-1t0hB:
undetectable		 5veuH-1t0hB:
18.33