SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  15
VAL A 151
VAL A 153
ILE A 166
 FMN  A 200 (-4.1A)
None
None
None
 0.69A 1igxA-1t0iA:
undetectable		 1igxA-1t0iA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 136
VAL A 139
LEU A 143
 None
 0.50A 1mz9B-1t0iA:
undetectable		 1mz9B-1t0iA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 154
ILE A  19
THR A 159
 None
 0.81A 1rx3A-1t0iA:
2.6		 1rx3A-1t0iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.05A 1rxcF-1t0iA:
2.3		 1rxcF-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.07A 1rxcL-1t0iA:
3.4		 1rxcL-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 181
VAL A   3
LYS A   1
ILE A 177
 None
 0.88A 2piwA-1t0iA:
undetectable		 2piwA-1t0iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 174
HIS A 173
VAL A 153
 None
 0.85A 3elzB-1t0iA:
undetectable		 3elzB-1t0iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.08A 3kvvA-1t0iA:
3.0		 3kvvA-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.09A 3kvvB-1t0iA:
undetectable		 3kvvB-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.11A 3kvvC-1t0iA:
2.9		 3kvvC-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.07A 3kvvD-1t0iA:
2.8		 3kvvD-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.06A 3kvvE-1t0iA:
2.3		 3kvvE-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.07A 3kvvF-1t0iA:
2.1		 3kvvF-1t0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 177
GLU A  28
ILE A   5
VAL A  89
VAL A   3
 None
 0.90A 3kw4A-1t0iA:
undetectable		 3kw4A-1t0iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  88
VAL A  89
ALA A 119
LEU A 120
PRO A  93
 None
None
None
None
FMN  A 200 (-4.2A)
 1.02A 3mb5A-1t0iA:
2.4		 3mb5A-1t0iA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 136
ALA A 119
GLY A   4
THR A  92
 None
 0.89A 3spkB-1t0iA:
undetectable		 3spkB-1t0iA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 136
CYH A 132
ILE A 107
ALA A 106
CYH A  16
 None
None
None
None
FMN  A 200 (-4.6A)
 1.12A 3vw1D-1t0iA:
undetectable		 3vw1D-1t0iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.05A 4e1vB-1t0iA:
2.2		 4e1vB-1t0iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 126
GLN A  94
ILE A 155
VAL A 157
 FMN  A 200 (-3.7A)
FMN  A 200 (-3.9A)
None
FMN  A 200 (-4.4A)
 1.08A 4e1vF-1t0iA:
2.1		 4e1vF-1t0iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 151
LEU A 120
VAL A 122
THR A  26
VAL A  89
 None
 0.89A 4e3hA-1t0iA:
undetectable		 4e3hA-1t0iA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  25
LYS A  24
ILE A   5
VAL A  91
 None
 1.05A 4em2A-1t0iA:
undetectable		 4em2A-1t0iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 154
ILE A  19
THR A 159
 None
 0.78A 4gh8A-1t0iA:
2.6		 4gh8A-1t0iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 136
TYR A  99
VAL A 121
LEU A 143
 None
 0.95A 4l1xA-1t0iA:
undetectable		 4l1xA-1t0iA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 124
LEU A 162
LEU A 170
THR A  26
 FMN  A 200 (-4.6A)
None
None
None
 1.13A 5hs6A-1t0iA:
6.0		 5hs6A-1t0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  50
VAL A  43
LEU A  45
ILE A   6
 None
 0.91A 6cb4A-1t0iA:
undetectable		 6cb4A-1t0iA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 0.99A 6emuA-1t0iA:
undetectable		 6emuA-1t0iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 1.03A 6emuB-1t0iA:
2.3		 6emuB-1t0iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1t0i YLR011WP
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 1.02A 6emuC-1t0iA:
2.3		 6emuC-1t0iA:
21.72