SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 8 LEU A 132
VAL A 157
LEU A 298
TYR A 166
 None
 0.91A 1jlbA-1t0pA:
undetectable		 1jlbA-1t0pA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1t0p INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		5 / 12 GLY B  78
SER B  79
ILE B  65
ILE B  34
LEU B  36
 None
NAG  B 302 (-2.9A)
None
None
None
 1.23A 1kyvA-1t0pB:
undetectable
1kyvE-1t0pB:
undetectable		 1kyvA-1t0pB:
21.79
1kyvE-1t0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1t0p INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		5 / 12 ILE B  34
LEU B  36
GLY B  78
SER B  79
ILE B  65
 None
None
None
NAG  B 302 (-2.9A)
None
 1.22A 1kyvB-1t0pB:
undetectable
1kyvC-1t0pB:
undetectable		 1kyvB-1t0pB:
21.79
1kyvC-1t0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1t0p INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		5 / 12 ILE B  34
LEU B  36
GLY B  78
SER B  79
ILE B  65
 None
None
None
NAG  B 302 (-2.9A)
None
 1.23A 1kyvC-1t0pB:
undetectable
1kyvD-1t0pB:
undetectable		 1kyvC-1t0pB:
21.79
1kyvD-1t0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1t0p INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		5 / 12 ILE B  34
LEU B  36
GLY B  78
SER B  79
ILE B  65
 None
None
None
NAG  B 302 (-2.9A)
None
 1.23A 1kyvD-1t0pB:
undetectable
1kyvE-1t0pB:
undetectable		 1kyvD-1t0pB:
21.79
1kyvE-1t0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		5 / 12 ALA B  35
SER A 270
THR A 273
ALA A 242
ASP A 244
 None
 1.40A 2qm9A-1t0pB:
undetectable		 2qm9A-1t0pB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 1t0p INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens) 		4 / 4 LYS B  42
ALA B  35
GLU B  37
LEU B  36
 None
None
MG  A 901 (-2.6A)
None
 1.22A 3vfjA-1t0pB:
undetectable		 3vfjA-1t0pB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 THR A 243
ASN A 207
GLY A 210
ILE A 236
 None
 0.90A 3w9tF-1t0pA:
undetectable		 3w9tF-1t0pA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A 276
LYS B  33
ALA A 242
 None
 1.40A 4ot2A-1t0pA:
undetectable		 4ot2A-1t0pA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU A 269
THR B  38
HIS A 264
 None
 0.82A 4q15A-1t0pA:
3.7		 4q15A-1t0pA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU A 269
THR B  38
HIS A 264
 None
 0.84A 4q15B-1t0pA:
4.0		 4q15B-1t0pA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 ASP A 239
ASP A 137
ASN A 207
 MG  A 901 ( 3.9A)
MG  A 901 ( 4.0A)
None
 0.83A 4q5mA-1t0pA:
undetectable		 4q5mA-1t0pA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1t0p INTEGRIN ALPHA-L
INTERCELLULAR
ADHESION MOLECULE-3
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU A 269
THR B  38
HIS A 264
 None
 0.83A 4ydqB-1t0pA:
4.0		 4ydqB-1t0pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A 901 (-2.7A)
None
None
 1.27A 5axaA-1t0pA:
2.6		 5axaA-1t0pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A 901 (-2.7A)
None
None
 1.30A 5axaC-1t0pA:
2.6		 5axaC-1t0pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 ILE A 212
PHE A 277
ILE A 236
LEU A 135
SER A 245
 None
 1.24A 5km9B-1t0pA:
undetectable		 5km9B-1t0pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 ALA A 242
LYS A 276
PHE A 209
ILE A 258
 None
 1.04A 5of1A-1t0pA:
undetectable		 5of1A-1t0pA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 8 VAL A 157
LEU A 295
LEU A 298
TYR A 166
 None
 0.92A 5y1yA-1t0pA:
undetectable		 5y1yA-1t0pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
 None
 1.34A 6awoA-1t0pA:
undetectable		 6awoA-1t0pA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
 None
 1.35A 6awqA-1t0pA:
undetectable		 6awqA-1t0pA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1t0p INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 LEU A 142
GLY A 138
HIS A 201
VAL A 133
VAL A 171
 None
 1.28A 6bxlB-1t0pA:
3.0		 6bxlB-1t0pA:
18.78