SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 4 ILE A  35
LEU A  32
VAL A  28
ALA A  21
 None
 0.98A 1mz9A-1t11A:
undetectable		 1mz9A-1t11A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 5 ILE A  35
LEU A  32
VAL A  28
ALA A  21
 None
 0.90A 1mz9C-1t11A:
undetectable		 1mz9C-1t11A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		5 / 11 PHE A 185
ILE A 195
PHE A 198
TYR A 221
PHE A 233
 None
 0.84A 2dg4A-1t11A:
undetectable		 2dg4A-1t11A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		5 / 8 GLY A 180
GLY A 170
ALA A 182
PHE A 198
PHE A 233
 None
 1.33A 2ha4A-1t11A:
undetectable		 2ha4A-1t11A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 8 TYR A 221
ILE A 195
GLY A 293
PHE A 233
 None
 0.92A 2vctC-1t11A:
0.3		 2vctC-1t11A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 7 TYR A 221
ILE A 195
GLY A 293
PHE A 233
 None
 0.95A 2vctD-1t11A:
0.0		 2vctD-1t11A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		5 / 10 PHE A 185
PHE A 168
PHE A 233
GLY A 179
PHE A 177
 None
 1.49A 3r6wA-1t11A:
undetectable
3r6wB-1t11A:
undetectable		 3r6wA-1t11A:
20.71
3r6wB-1t11A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		5 / 12 PHE A 185
ILE A 195
PHE A 198
TYR A 221
PHE A 233
 None
 0.86A 5hkgA-1t11A:
undetectable		 5hkgA-1t11A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 5 ALA A 231
VAL A 215
PHE A 177
ILE A 195
 None
 0.95A 5of1A-1t11A:
undetectable		 5of1A-1t11A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 5 ALA A 231
VAL A 215
PHE A 177
ILE A 195
 None
 1.01A 5of1B-1t11A:
undetectable		 5of1B-1t11A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1t11 TRIGGER FACTOR
(Vibrio
cholerae) 		4 / 5 PRO A 303
GLU A 142
ARG A 145
THR A 143
 None
 1.50A 5uxcA-1t11A:
undetectable		 5uxcA-1t11A:
22.91