SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1
(Nicotiana
tabacum) 		5 / 12 ALA A  66
GLY A  64
LEU A  51
ALA A  55
LEU A  18
 None
 1.13A 1mjqC-1t12A:
undetectable
1mjqD-1t12A:
undetectable		 1mjqC-1t12A:
21.93
1mjqD-1t12A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1
(Nicotiana
tabacum) 		5 / 12 ALA A  66
GLY A  64
LEU A  51
ALA A  55
LEU A  18
 None
 1.13A 1mjqI-1t12A:
undetectable
1mjqJ-1t12A:
undetectable		 1mjqI-1t12A:
21.93
1mjqJ-1t12A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1
(Nicotiana
tabacum) 		4 / 8 LEU A  15
VAL A  31
LEU A  34
GLY A   5
 None
 0.91A 4r3aA-1t12A:
undetectable		 4r3aA-1t12A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1
(Nicotiana
tabacum) 		4 / 8 GLY A  30
LEU A  34
VAL A  75
LEU A  51
 None
 0.83A 6czmD-1t12A:
undetectable
6czmF-1t12A:
undetectable		 6czmD-1t12A:
15.19
6czmF-1t12A:
15.19