SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXZ_A_0LIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	5 / 9	LEU A 123 VAL A 24 ILE A 34 ARG A 71 VAL A 109	None	1.46A	3oxzA-1t17A: undetectable	3oxzA-1t17A: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1A_C_CHDC305_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.21A	5b1aA-1t17A: undetectable 5b1aC-1t17A: undetectable 5b1aP-1t17A: undetectable	5b1aA-1t17A: 14.46 5b1aC-1t17A: 18.56 5b1aP-1t17A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.20A	5b3sA-1t17A: undetectable 5b3sC-1t17A: undetectable 5b3sP-1t17A: undetectable	5b3sA-1t17A: 14.46 5b3sC-1t17A: 18.56 5b3sP-1t17A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z85_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.20A	5z85A-1t17A: undetectable 5z85C-1t17A: undetectable 5z85P-1t17A: undetectable	5z85A-1t17A: 14.46 5z85C-1t17A: 18.56 5z85P-1t17A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z86_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.21A	5z86A-1t17A: undetectable 5z86C-1t17A: undetectable 5z86P-1t17A: undetectable	5z86A-1t17A: 14.46 5z86C-1t17A: 18.56 5z86P-1t17A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCO_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.23A	5zcoA-1t17A: undetectable 5zcoC-1t17A: undetectable 5zcoP-1t17A: undetectable	5zcoA-1t17A: 14.46 5zcoC-1t17A: 18.56 5zcoP-1t17A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCQ_C_CHDC301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	1t17	CONSERVED HYPOTHETICAL PROTEIN (Caulobacter vibrioides)	4 / 8	ASP A 15 THR A 13 TYR A 12 LEU A 145	None	1.21A	5zcqA-1t17A: undetectable 5zcqC-1t17A: undetectable 5zcqP-1t17A: undetectable	5zcqA-1t17A: 14.46 5zcqC-1t17A: 18.56 5zcqP-1t17A: 18.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OXZ_A_0LIA1_2","TYROSINE-PROTEIN KINASE ABL1","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",5,"LEU A 123;VAL A  24;ILE A  34;ARG A  71;VAL A 109","None","1.46A","3oxzA-1t17A:undetectable","3oxzA-1t17A:19.70"],["5B1A_C_CHDC305_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.21A","5b1aA-1t17A:undetectable;5b1aC-1t17A:undetectable;5b1aP-1t17A:undetectable","5b1aA-1t17A:14.46;5b1aC-1t17A:18.56;5b1aP-1t17A:18.56"],["5B3S_C_CHDC301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.20A","5b3sA-1t17A:undetectable;5b3sC-1t17A:undetectable;5b3sP-1t17A:undetectable","5b3sA-1t17A:14.46;5b3sC-1t17A:18.56;5b3sP-1t17A:18.56"],["5Z85_C_CHDC301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.20A","5z85A-1t17A:undetectable;5z85C-1t17A:undetectable;5z85P-1t17A:undetectable","5z85A-1t17A:14.46;5z85C-1t17A:18.56;5z85P-1t17A:18.56"],["5Z86_C_CHDC301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.21A","5z86A-1t17A:undetectable;5z86C-1t17A:undetectable;5z86P-1t17A:undetectable","5z86A-1t17A:14.46;5z86C-1t17A:18.56;5z86P-1t17A:18.56"],["5ZCO_C_CHDC301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.23A","5zcoA-1t17A:undetectable;5zcoC-1t17A:undetectable;5zcoP-1t17A:undetectable","5zcoA-1t17A:14.46;5zcoC-1t17A:18.56;5zcoP-1t17A:18.56"],["5ZCQ_C_CHDC301_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","1t17","CONSERVED HYPOTHETICAL PROTEIN","Caulobacter vibrioides",4,"ASP A  15;THR A  13;TYR A  12;LEU A 145","None","1.21A","5zcqA-1t17A:undetectable;5zcqC-1t17A:undetectable;5zcqP-1t17A:undetectable","5zcqA-1t17A:14.46;5zcqC-1t17A:18.56;5zcqP-1t17A:18.56"]]