SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 THR A 406
ASN A 511
THR A 395
GLY A 509
 None
 1.00A 1bu5B-1t1eA:
undetectable		 1bu5B-1t1eA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 THR A 111
GLU A 157
HIS A  20
LEU A 160
 None
 1.39A 1d4fC-1t1eA:
3.7		 1d4fC-1t1eA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 9 ILE A 220
TRP A 318
ASP A 251
GLY A 295
PHE A 296
 None
 1.36A 1i00A-1t1eA:
0.0		 1i00A-1t1eA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 11 PHE A 172
ALA A 468
LEU A 278
ALA A 279
ALA A 478
 None
 1.06A 1jinA-1t1eA:
undetectable		 1jinA-1t1eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 TRP A 397
GLY A 381
VAL A 396
ALA A 470
GLY A 355
 None
 1.12A 1kiaB-1t1eA:
2.4		 1kiaB-1t1eA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 HIS A  71
VAL A 345
GLY A 489
GLU A  75
HIS A 305
 None
 1.11A 1kxhA-1t1eA:
undetectable		 1kxhA-1t1eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 ASP A 362
ASN A 430
GLY A 409
GLU A 360
GLY A 359
 None
 1.18A 1mehA-1t1eA:
undetectable		 1mehA-1t1eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.83A 1mt1A-1t1eA:
undetectable
1mt1F-1t1eA:
undetectable		 1mt1A-1t1eA:
7.32
1mt1F-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.85A 1mt1B-1t1eA:
undetectable
1mt1C-1t1eA:
0.0		 1mt1B-1t1eA:
10.26
1mt1C-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 ALA A  76
LEU A  54
LEU A 343
ASP A 339
 None
 0.91A 1mt1D-1t1eA:
0.0
1mt1E-1t1eA:
0.0		 1mt1D-1t1eA:
10.26
1mt1E-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.87A 1mt1G-1t1eA:
undetectable
1mt1J-1t1eA:
undetectable		 1mt1G-1t1eA:
7.32
1mt1J-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.89A 1mt1H-1t1eA:
undetectable
1mt1K-1t1eA:
undetectable		 1mt1H-1t1eA:
10.26
1mt1K-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.79A 1n13B-1t1eA:
0.0
1n13C-1t1eA:
0.0		 1n13B-1t1eA:
10.26
1n13C-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.84A 1n13D-1t1eA:
undetectable
1n13E-1t1eA:
undetectable		 1n13D-1t1eA:
10.26
1n13E-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.81A 1n13A-1t1eA:
undetectable
1n13F-1t1eA:
undetectable		 1n13A-1t1eA:
7.32
1n13F-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.86A 1n13H-1t1eA:
undetectable
1n13K-1t1eA:
undetectable		 1n13H-1t1eA:
10.26
1n13K-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.84A 1n13G-1t1eA:
undetectable
1n13J-1t1eA:
undetectable		 1n13G-1t1eA:
7.32
1n13J-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.80A 1n13I-1t1eA:
0.0
1n13L-1t1eA:
undetectable		 1n13I-1t1eA:
7.32
1n13L-1t1eA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 TRP A 397
GLY A 381
VAL A 396
ALA A 470
GLY A 355
 None
 1.13A 1nbiA-1t1eA:
undetectable		 1nbiA-1t1eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 TRP A 397
GLY A 381
VAL A 396
ALA A 470
GLY A 355
 None
 1.11A 1nbiB-1t1eA:
undetectable		 1nbiB-1t1eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 THR A 466
ASP A 353
GLY A 404
ASP A 399
ALA A 178
 None
 1.12A 1oltA-1t1eA:
0.3		 1oltA-1t1eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ASN A 481
GLY A 485
LEU A 545
THR A 346
ILE A 313
 None
 1.16A 1p93B-1t1eA:
undetectable		 1p93B-1t1eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 7 MET A 333
ALA A 331
ILE A 330
ASP A 293
PHE A 296
 None
 1.33A 1upfB-1t1eA:
undetectable		 1upfB-1t1eA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ASN A 291
GLY A 295
MET A 333
PHE A 337
GLY A 319
 None
 1.42A 2fqyA-1t1eA:
6.8		 2fqyA-1t1eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 11 GLY A 359
SER A 354
ASN A 515
THR A 357
GLY A 355
 None
 1.33A 2hmaA-1t1eA:
undetectable		 2hmaA-1t1eA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.79A 2qqcB-1t1eA:
undetectable
2qqcC-1t1eA:
undetectable		 2qqcB-1t1eA:
9.89
2qqcC-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.79A 2qqcA-1t1eA:
undetectable
2qqcF-1t1eA:
undetectable		 2qqcA-1t1eA:
7.32
2qqcF-1t1eA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.82A 2qqcG-1t1eA:
undetectable
2qqcJ-1t1eA:
undetectable		 2qqcG-1t1eA:
7.32
2qqcJ-1t1eA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.77A 2qqcI-1t1eA:
undetectable
2qqcL-1t1eA:
undetectable		 2qqcI-1t1eA:
7.32
2qqcL-1t1eA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.85A 2qqcH-1t1eA:
undetectable
2qqcK-1t1eA:
undetectable		 2qqcH-1t1eA:
9.89
2qqcK-1t1eA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.81A 2qqdA-1t1eA:
undetectable
2qqdE-1t1eA:
undetectable		 2qqdA-1t1eA:
7.51
2qqdE-1t1eA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 ARG A 437
LEU A 532
ASP A 441
LEU A 377
 None
 0.80A 2qqdB-1t1eA:
undetectable
2qqdC-1t1eA:
undetectable		 2qqdB-1t1eA:
9.71
2qqdC-1t1eA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ILE A 413
PHE A 296
ALA A 331
ILE A 300
ILE A 316
 None
 1.05A 2rlcA-1t1eA:
0.0		 2rlcA-1t1eA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 PRO A 197
GLY A 451
THR A 450
THR A 193
LEU A 270
 None
 1.03A 2zifA-1t1eA:
undetectable		 2zifA-1t1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		3 / 3 TYR A 204
TYR A 452
GLY A 444
 None
 0.70A 3eteB-1t1eA:
undetectable
3eteD-1t1eA:
1.7
3eteF-1t1eA:
undetectable		 3eteB-1t1eA:
21.86
3eteD-1t1eA:
21.86
3eteF-1t1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 LYS A 483
LEU A 484
GLN A 542
LEU A 544
 None
 1.06A 3h5gB-1t1eA:
undetectable
3h5gC-1t1eA:
undetectable		 3h5gB-1t1eA:
8.97
3h5gC-1t1eA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 GLU A 394
VAL A 200
VAL A 469
ALA A 446
 None
 1.05A 3kp6B-1t1eA:
0.0		 3kp6B-1t1eA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 VAL A 200
TYR A 452
TYR A 204
GLU A 394
 None
 1.23A 3q5sA-1t1eA:
1.3		 3q5sA-1t1eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 LEU A 160
THR A  43
VAL A  45
THR A 301
PHE A 369
 None
 1.25A 3tbgC-1t1eA:
0.0		 3tbgC-1t1eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		6 / 12 VAL A 113
LEU A 100
VAL A 146
ILE A  40
LEU A 129
VAL A 127
 None
 1.46A 3w68D-1t1eA:
undetectable		 3w68D-1t1eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 8 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.33A 4feuD-1t1eA:
2.6		 4feuD-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 11 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.31A 4feuB-1t1eA:
1.8
4feuE-1t1eA:
0.3		 4feuB-1t1eA:
19.77
4feuE-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.28A 4fevA-1t1eA:
undetectable		 4fevA-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 7 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.32A 4fevB-1t1eA:
undetectable		 4fevB-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.25A 4fexD-1t1eA:
0.2		 4fexD-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 9 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.26A 4fexE-1t1eA:
1.6		 4fexE-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 11 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.21A 4gkhC-1t1eA:
1.7
4gkhD-1t1eA:
1.0		 4gkhC-1t1eA:
19.77
4gkhD-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 ASP A 457
ASN A 255
ASP A 227
GLU A 228
 None
 1.10A 4gkhD-1t1eA:
undetectable		 4gkhD-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 11 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.23A 4gkhI-1t1eA:
1.3
4gkhJ-1t1eA:
1.3		 4gkhI-1t1eA:
19.77
4gkhJ-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 6 ASP A 457
ASN A 255
ASP A 227
GLU A 228
 None
 1.12A 4gkhJ-1t1eA:
undetectable		 4gkhJ-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.20A 4gkiG-1t1eA:
1.4
4gkiH-1t1eA:
0.6		 4gkiG-1t1eA:
19.77
4gkiH-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ASP A 457
ASN A 255
GLU A 221
ASP A 227
GLU A 228
 None
 1.25A 4gkiK-1t1eA:
1.3
4gkiL-1t1eA:
1.3		 4gkiK-1t1eA:
19.77
4gkiL-1t1eA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 SER A 115
ALA A 294
SER A  41
THR A  43
 None
 0.92A 4ikjA-1t1eA:
undetectable
4ikjB-1t1eA:
undetectable		 4ikjA-1t1eA:
14.40
4ikjB-1t1eA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 ALA A 294
SER A  41
THR A  43
SER A 115
 None
 0.94A 4ikkA-1t1eA:
undetectable
4ikkB-1t1eA:
undetectable		 4ikkA-1t1eA:
14.40
4ikkB-1t1eA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		6 / 10 THR A 346
SER A 312
ALA A 218
ILE A 284
ALA A 478
ALA A 474
 None
 1.47A 4lbgA-1t1eA:
4.6		 4lbgA-1t1eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ASN A 481
GLY A 485
LEU A 545
THR A 346
ILE A 313
 None
 1.13A 4p6xA-1t1eA:
undetectable		 4p6xA-1t1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 ASN A 481
GLY A 485
LEU A 545
THR A 346
ILE A 313
 None
 1.09A 4p6xE-1t1eA:
undetectable		 4p6xE-1t1eA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 ARG A 335
GLY A 110
ALA A 109
GLY A  82
 None
 0.94A 4u9uA-1t1eA:
undetectable		 4u9uA-1t1eA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 LEU A 384
TYR A 204
ALA A 443
ILE A 506
 None
 1.20A 4y03B-1t1eA:
undetectable		 4y03B-1t1eA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 10 ALA A 326
ILE A 330
GLY A 161
LEU A 160
ALA A 332
 None
 1.28A 5ajqB-1t1eA:
undetectable		 5ajqB-1t1eA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 GLY A  99
PHE A  88
GLY A  82
GLY A 110
THR A 101
 None
 1.06A 5eqbA-1t1eA:
undetectable		 5eqbA-1t1eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		6 / 12 ILE A 519
VAL A 367
ALA A 350
ALA A 351
VAL A 439
GLY A 465
 None
 1.43A 5igtA-1t1eA:
undetectable		 5igtA-1t1eA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 PRO A 471
ALA A 474
ALA A 275
ILE A 217
 None
 0.82A 5jncD-1t1eA:
undetectable		 5jncD-1t1eA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 7 GLY A 266
GLU A 267
ALA A 467
ASN A 262
 None
 0.96A 5mvsA-1t1eA:
undetectable		 5mvsA-1t1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 GLY A 266
GLU A 267
ALA A 467
ASN A 262
 None
 0.97A 5mvsB-1t1eA:
undetectable		 5mvsB-1t1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 8 ILE A 220
ASP A 251
GLY A 295
PHE A 296
 None
 0.90A 5nooD-1t1eA:
undetectable		 5nooD-1t1eA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		5 / 12 VAL A 502
LEU A 210
ALA A 543
LEU A 484
LEU A 491
 None
 1.14A 6ew0H-1t1eA:
2.8		 6ew0H-1t1eA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1t1e KUMAMOLISIN
(Bacillus
sp.
MN-32) 		4 / 5 ASN A 430
GLY A 320
HIS A 366
ASP A 362
 None
 0.93A 6gh9A-1t1eA:
0.0		 6gh9A-1t1eA:
9.09