SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1t1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.46A 1d4fA-1t1uA:
undetectable		 1d4fA-1t1uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  68
MET A 533
PHE A 534
 None
 1.33A 1d4fA-1t1uA:
undetectable		 1d4fA-1t1uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.42A 1d4fB-1t1uA:
undetectable		 1d4fB-1t1uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 SER A 550
CYH A 584
ASN A 575
TYR A 574
 None
 0.96A 1dssG-1t1uA:
undetectable		 1dssG-1t1uA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 SER A 550
CYH A 584
ASN A 575
TYR A 574
 None
 0.95A 1dssR-1t1uA:
undetectable		 1dssR-1t1uA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 11 ALA A 434
LEU A 547
ILE A 585
PHE A 583
ILE A 427
 None
 1.07A 1dyrA-1t1uA:
undetectable		 1dyrA-1t1uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 THR A 383
LEU A 387
LEU A 394
 None
 0.55A 1mz9C-1t1uA:
undetectable		 1mz9C-1t1uA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 TYR A 137
ARG A 167
GLN A 164
 None
 1.01A 1tw4A-1t1uA:
undetectable		 1tw4A-1t1uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 SER A 335
SER A 106
ARG A  99
GLU A 333
 None
 1.33A 2c8aA-1t1uA:
undetectable		 2c8aA-1t1uA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 SER A 264
ASP A 263
ARG A 257
GLU A 274
 None
 1.10A 2cdqB-1t1uA:
0.0		 2cdqB-1t1uA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 11 LEU A 216
SER A 132
ILE A 131
VAL A 196
LEU A 207
 None
 1.00A 2kawA-1t1uA:
undetectable		 2kawA-1t1uA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 11 LEU A 168
LEU A 130
VAL A 134
VAL A 196
ILE A 277
 None
 1.22A 2uxoB-1t1uA:
0.3		 2uxoB-1t1uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 ASP A 402
SER A 596
TYR A 435
CYH A 591
 None
 1.40A 2xz5A-1t1uA:
undetectable
2xz5C-1t1uA:
undetectable		 2xz5A-1t1uA:
16.51
2xz5C-1t1uA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 ILE A 416
SER A 606
ALA A 602
LEU A 431
ILE A 581
 None
 1.24A 3adsB-1t1uA:
undetectable		 3adsB-1t1uA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 VAL A 343
PHE A 403
LEU A 300
HIS A 334
SER A 550
 None
 1.24A 3apvA-1t1uA:
0.0		 3apvA-1t1uA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.48A 3ce6C-1t1uA:
undetectable		 3ce6C-1t1uA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 GLY A 302
SER A 247
THR A 246
VAL A 331
ALA A 310
 None
 1.28A 3d91B-1t1uA:
undetectable		 3d91B-1t1uA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 SER A 550
CYH A 584
ASN A 575
TYR A 574
 None
 0.96A 3dmtC-1t1uA:
undetectable		 3dmtC-1t1uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 LEU A 431
TYR A 435
LEU A 438
LEU A 547
 None
 0.88A 3f33A-1t1uA:
undetectable		 3f33A-1t1uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.46A 3g1uC-1t1uA:
undetectable		 3g1uC-1t1uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 10 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.49A 3h9uA-1t1uA:
undetectable		 3h9uA-1t1uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 GLY A 323
ASP A 325
ARG A 295
MET A 354
 None
 1.36A 3qx3A-1t1uA:
1.9		 3qx3A-1t1uA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 LEU A 431
TYR A 435
ALA A 602
LEU A 547
 None
 1.08A 3ravA-1t1uA:
undetectable		 3ravA-1t1uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 LEU A 431
TYR A 435
ALA A 602
LEU A 547
 None
 1.05A 3rd0A-1t1uA:
undetectable		 3rd0A-1t1uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 PHE A 599
ILE A 416
PHE A 583
THR A 549
ALA A 605
 None
 1.30A 3ua1A-1t1uA:
undetectable		 3ua1A-1t1uA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 4 TRP A 253
LEU A 270
LEU A 261
THR A 258
 None
 1.34A 4bboD-1t1uA:
0.0		 4bboD-1t1uA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 VAL A  58
ARG A  60
MET A 533
GLU A 532
 None
 1.22A 4hojA-1t1uA:
undetectable		 4hojA-1t1uA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 7 ALA A 523
PRO A 530
LEU A  67
LEU A  71
 None
 0.85A 4iomA-1t1uA:
undetectable		 4iomA-1t1uA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 ALA A 523
PRO A 530
LEU A  67
LEU A  71
 None
 0.85A 4jjkA-1t1uA:
undetectable		 4jjkA-1t1uA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.49A 4lvcC-1t1uA:
undetectable		 4lvcC-1t1uA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 GLY A 571
ILE A 585
LEU A 431
TYR A 435
LEU A 438
 None
 0.99A 4pd4C-1t1uA:
undetectable		 4pd4C-1t1uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 THR A 477
LEU A 438
VAL A 443
LEU A 442
 None
 0.89A 4r38B-1t1uA:
undetectable		 4r38B-1t1uA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 8 THR A 477
LEU A 438
VAL A 443
LEU A 442
 None
 0.88A 4r38D-1t1uA:
undetectable		 4r38D-1t1uA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 TYR A 562
ASP A 424
LEU A 607
PHE A 583
ILE A 427
 None
 1.14A 5dv4A-1t1uA:
undetectable		 5dv4A-1t1uA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 6 THR A 181
ASP A 180
LEU A 174
ASP A 315
 None
 1.16A 5tdzA-1t1uA:
undetectable		 5tdzA-1t1uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 ARG A 463
PRO A 444
TYR A 539
 None
 0.75A 5tzoB-1t1uA:
undetectable		 5tzoB-1t1uA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.49A 5v96B-1t1uA:
undetectable		 5v96B-1t1uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.48A 5v96C-1t1uA:
undetectable		 5v96C-1t1uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 5 GLY A 323
ASP A 325
ARG A 295
MET A 354
 None
 1.37A 5zrfB-1t1uA:
undetectable		 5zrfB-1t1uA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		4 / 4 GLY A 323
ASP A 325
ARG A 295
MET A 354
 None
 1.34A 5zrfA-1t1uA:
1.9		 5zrfA-1t1uA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		3 / 3 GLY A 509
ASP A 460
ILE A 462
 None
 0.59A 6dgxB-1t1uA:
undetectable		 6dgxB-1t1uA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.45A 6gbnA-1t1uA:
undetectable		 6gbnA-1t1uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 1t1u CHOLINE
O-ACETYLTRANSFERASE
(Rattus
norvegicus) 		5 / 12 LEU A 516
LEU A  31
GLY A  62
MET A 533
PHE A 534
 None
 1.47A 6gbnD-1t1uA:
undetectable		 6gbnD-1t1uA:
19.72